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Genetic diversity and antibiotic resistance in Shigella dysenteriae and Shigella boydii strains isolated from children aged <5 years in Egypt

  • A. M. EL-GENDY (a1), A. MANSOUR (a1), M. A. WEINER (a1), G. PIMENTEL (a2), A. W. ARMSTRONG (a1), S. Y. N. YOUNG (a1), N. ELSAYED (a3) and J. D. KLENA (a1)
  • DOI: http://dx.doi.org/10.1017/S0950268811000525
  • Published online: 07 April 2011
Abstract
SUMMARY

Diversity within Shigella dysenteriae (n=40) and Shigella boydii (n=30) isolates from children living in Egypt aged <5 years was investigated. Shigella-associated diarrhoea occurred mainly in summer months and in children aged <3 years, it commonly presented with vomiting and fever. Serotypes 7 (30%), 2 (28%), and 3 (23%) accounted for most of S. dysenteriae isolates; 50% of S. boydii isolates were serotype 2. S. dysenteriae and S. boydii isolates were often resistant to ampicillin, chloramphenicol and tetracycline (42%, 17%, respectively), although resistance varied among serotypes. Pulsed-field gel electrophoresis separated the isolates into distinct clusters correlating with species and serotype. Genetic differences in trimethoprim/sulfamethoxazole and β-lactam-encoding resistance genes were also evident. S. dysenteriae and S. boydii are genetically diverse pathogens in Egypt; the high level of multidrug resistance associated with both pathogens and resistance to the most available inexpensive antibiotics underlines the importance of continuing surveillance.

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Corresponding author
*Author for correspondence: Professor J. D. Klena, Unit 7300, Box 060 DPO AP 96521-0050USA. (Email: irc4@cn.cdc.gov)
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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