Skip to main content
    • Aa
    • Aa

Genetic relationships between southern African SAT-2 isolates of foot-and-mouth-disease virus

  • W. Vosloo (a1), N. J. Knowles (a2) and G. R. Thomson (a1)

Sequencing of part of the 1D gene of foot-and-mouth disease virus was used to determine the relationships between SAT-2 viruses isolated from outbreaks which occurred in cattle in Zimbabwe and Namibia and in impala in South Africa between 1979 and 1989. The results demonstrated that the outbreaks in different countries were unrelated. Surprisingly close relationships were shown between all SAT-2 viruses isolated from cattle in Zimbabwe since 1983 but the two major epizootics which occurred in 1989 were caused by viruses which were clearly different. Conversely, two apparently unrelated outbreaks in impala in South Africa were caused by viruses which could not be distinguished.

Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2. AMQ King , BO Underwood , D McCahon , JWI Newman , F Brown . Biochemical identification of viruses causing the 1981 outbreaks of foot-and-mouth disease in the UK. Nature 1981; 293: 479–80.

3. JB Condy , KAJ Hermann , RS Hedger . Foot-and-mouth disease in wildlife in Rhodesia and other African territories. J Comp Pathol 1969; 79: 2731.

4. RS Hedger . Foot-and-mouth disease in wildlife with particular reference to the African buffalo (Syncerus caffer). In: LA Page , ed. Wildlife diseases. New York: Plenum Publishing Corporation, 1976: 235–44.

6. RS Hedger . Foot-and-mouth disease and the African Buffalo (Syncerus caffer). J Comp Pathol 1972; 82: 1928.

8. F Sobrino , EL Palma , E Beck , . Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations. Gene 1986; 50: 149–59.

11. AM Martinez , C Carrillo , J Plana . . Genetic and immunogenic variations among closely related isolates of foot-and-mouth disease virus. Gene 1988; 62: 7584.

12. HL Bachrach , DO Morgan , DM Moore . Foot-and-mouth disease virus immunogenic capsid protein VPT: N-terminal sequences and immunogenic peptides obtained by CNBr and tryptic cleavages. Intervirology 1979; 12: 6572.

13. K Strohmaier , R Franze , K-H Adam . Location and characterization of the antigenic portion of the FMDV immunizing protein. J Gen Virol 1982; 59: 295306.

14. HM Geysen , SJ Barteling , RH Meloen . Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein. Proc Nat Acad Sci USA 1985; 82: 178–82.

16. R Rico-Hesse , MA Pallansch , BK Nottay , OM Kew . Geographic distribution of wild poliovirus type 1 genotypes. Virology 1987; 160: 311–22.

17. AC Palmenberg , EM Kirby , MR Janda , . The nucleotide and deduced amino acid sequences of encephalomyocarditis viral polyprotein coding region. Nucleic Acids Res 1984; 12: 2969–85.

18. Q-C Xie , D McCahon , JR Crowther , GJ Belsham , KC McCullough . Neutralization of foot-and-mouth disease virus can be mediated through any of at least three separate antigenic sites. J Gen Virol 1987; 68: 1637–47.

19. D Zimmern , P Kaesberg . 3′-terminal nucleotide sequence of encephalomyocarditis virus RNA determined by reverse transcriptase and chain-terminating inhibitors. Proc Nat Acad Sci USA 1978; 75: 4257–61.

22. F Sobrino , M Dávila , J Ortin , E Domingo . Multiple genetic variants arise in the course of foot-and-mouth disease virus in cell culture. Virology 1983; 128: 310–8.

24. E Domingo , M Dávila , J Ortín . Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth disease virus. Gene 1980; 11: 333–46.

25. GN Weddell , DG Yansura , DJ Dowbenko , . Sequence variation in the gene for the immunogenic capsid protein VP1 of foot-and-mouth disease virus type A. Proc Nat Acad Sci USA 1985; 82: 2618–22.

26. C Carrillo , J Dopazo , A Moya . . Comparison of vaccine strains and the virus causing the 1986 foot-and-mouth disease outbreak in Spain: epizootiological analysis. Virus Res 1990; 15: 4556.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 4 *
Loading metrics...

Abstract views

Total abstract views: 38 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 21st August 2017. This data will be updated every 24 hours.