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Genetic relationships between southern African SAT-2 isolates of foot-and-mouth-disease virus

  • W. Vosloo (a1), N. J. Knowles (a2) and G. R. Thomson (a1)

Sequencing of part of the 1D gene of foot-and-mouth disease virus was used to determine the relationships between SAT-2 viruses isolated from outbreaks which occurred in cattle in Zimbabwe and Namibia and in impala in South Africa between 1979 and 1989. The results demonstrated that the outbreaks in different countries were unrelated. Surprisingly close relationships were shown between all SAT-2 viruses isolated from cattle in Zimbabwe since 1983 but the two major epizootics which occurred in 1989 were caused by viruses which were clearly different. Conversely, two apparently unrelated outbreaks in impala in South Africa were caused by viruses which could not be distinguished.

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1.Mutiwanyuka CMA. Foot-and-mouth disease and the marketing of beef. In: Proceedings of the International Foot-and-Mouth Disease Conference. Zimbabwe: Society for Animal Production, 1989; 34–8.
2.King AMQ, Underwood BO, McCahon D, Newman JWI, Brown F. Biochemical identification of viruses causing the 1981 outbreaks of foot-and-mouth disease in the UK. Nature 1981; 293: 479–80.
3.Condy JB, Hermann KAJ, Hedger RS. Foot-and-mouth disease in wildlife in Rhodesia and other African territories. J Comp Pathol 1969; 79: 2731.
4.Hedger RS. Foot-and-mouth disease in wildlife with particular reference to the African buffalo (Syncerus caffer). In: Page LA, ed. Wildlife diseases. New York: Plenum Publishing Corporation, 1976: 235–44.
5.Gainaru MD, Thomson GR, Bengis RG, Esterhuysen JJ, Bruce W, Pini A. Foot-and-mouth disease and the African buffalo (Syncerus caffer). II. Virus excretion and transmission during acute infection. Onderstepoort J Vet Res 1986; 53: 7585.
6.Hedger RS. Foot-and-mouth disease and the African Buffalo (Syncerus caffer). J Comp Pathol 1972; 82: 1928.
7.Thomson GR, Bengis RG, Esterhuysen JJ, Pini A. Maintenance mechanisms for foot-and-mouth disease virus in the Kruger National Park and potential avenues for it's escape into domestic animal populations. In: Proceedings of XIIIth World Congress on Diseases of Cattle. Durban: South African Veterinary Association, 1984: 33–8.
8.Sobrino F, Palma EL, Beck E, et al. . Fixation of mutations in the viral genome during an outbreak of foot-and-mouth disease: heterogeneity and rate variations. Gene 1986; 50: 149–59.
9.Beck E, Strohmaier K. Subtyping of European foot-and-mouth disease virus strains by nucleotide sequence determination. J Virol 1987; 61: 1621–9.
10.Piccone ME, Kaplan G, Giavidoni L, Domingo E, Palma EL. VP1 of serotype C foot-and-mouth disease viruses: long-term conservation of sequences. J Virol 1988; 62: 1469–73.
11.Martinez AM, Carrillo C, Plana J. et al. . Genetic and immunogenic variations among closely related isolates of foot-and-mouth disease virus. Gene 1988; 62: 7584.
12.Bachrach HL, Morgan DO, Moore DM. Foot-and-mouth disease virus immunogenic capsid protein VPT: N-terminal sequences and immunogenic peptides obtained by CNBr and tryptic cleavages. Intervirology 1979; 12: 6572.
13.Strohmaier K, Franze R, Adam K-H. Location and characterization of the antigenic portion of the FMDV immunizing protein. J Gen Virol 1982; 59: 295306.
14.Geysen HM, Barteling SJ, Meloen RH. Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein. Proc Nat Acad Sci USA 1985; 82: 178–82.
15.Esterhuysen JJ, Thomson GR, Flammand JRB, Bengis RG. Buffalo in the northern Natal game parks show no serological evidence of infection with foot-and-mouth disease virus. Onderstepoort J Vet Res 1985; 52: 63–6.
16.Rico-Hesse R, Pallansch MA, Nottay BK, Kew OM. Geographic distribution of wild poliovirus type 1 genotypes. Virology 1987; 160: 311–22.
17.Palmenberg AC, Kirby EM, Janda MR, et al. . The nucleotide and deduced amino acid sequences of encephalomyocarditis viral polyprotein coding region. Nucleic Acids Res 1984; 12: 2969–85.
18.Xie Q-C, McCahon D, Crowther JR, Belsham GJ, McCullough KC. Neutralization of foot-and-mouth disease virus can be mediated through any of at least three separate antigenic sites. J Gen Virol 1987; 68: 1637–47.
19.Zimmern D, Kaesberg P. 3′-terminal nucleotide sequence of encephalomyocarditis virus RNA determined by reverse transcriptase and chain-terminating inhibitors. Proc Nat Acad Sci USA 1978; 75: 4257–61.
20.Felsenstein J. PHYLIP 3.2 Manual 1989. University of California Herbarium, Berkeley, California.
21.Condy JB. A history of foot-and-mouth disease in Rhodesia. Rhod Vet J 1979; 10: 210.
22.Sobrino F, Dávila M, Ortin J, Domingo E. Multiple genetic variants arise in the course of foot-and-mouth disease virus in cell culture. Virology 1983; 128: 310–8.
23.Samuel AR, Knowles NJ, Kitching RP. Serological and biochemical analysis of some recent type A foot-and-mouth disease virus isolates from the Middle East. Epidemiol Infect 1988; 101: 577–90.
24.Domingo E, Dávila M, Ortín J. Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth disease virus. Gene 1980; 11: 333–46.
25.Weddell GN, Yansura DG, Dowbenko DJ, et al. . Sequence variation in the gene for the immunogenic capsid protein VP1 of foot-and-mouth disease virus type A. Proc Nat Acad Sci USA 1985; 82: 2618–22.
26.Carrillo C, Dopazo J, Moya A. et al. . Comparison of vaccine strains and the virus causing the 1986 foot-and-mouth disease outbreak in Spain: epizootiological analysis. Virus Res 1990; 15: 4556.
27.Palmenberg AC. Sequence alignments of picornaviral capsid proteins. In: Semler BL, Ehrenfeld E, eds. Molecular aspects of picornavirus infection and detection. Washington. DC: American Society for Microbiology, 1989; 211–41.
28.Gebauer F, De La Torre JC, Gomes I. et al. . Rapid selection of genetic and antigenic variants of foot-and-mouth disease virus during persistence in cattle. J Virol 1988; 62: 2041–9.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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