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HBV-DNA, HBeAg/anti-HBe serological status in hepatitis B chronic individuals from central Italy

  • M. Rapicetta (a1), V. Di Nardo (a2), C. Rozera (a1), G. Marinucci (a3), D. Francisci (a4), B. Sarrecchia (a1), C. Ricci (a5) and F. Albertoni (a6)...

Summary

A population of 488 HBsAg carrier individuals, from central Italy, classified on the basis of biochemical, clinical and histological parameters, was analysed for the presence of HBV-DNA in serum and its relationship with HBeAg/anti-HBe markers. The prevalence of HBV-DNA was 32·8% in chronic patients with biopsy-proven liver disease, and 20 and 4·3% respectively in asymptomatic carriers with and without altered ALT levels. The values in chronic patients were correlated with the histological activity.

Concordance of HBV-DNA presence and HBeAg positivity was observed in only 61·4% of cases. However HBV-DNA prevalence in sera of anti-HBe positive individuals was very low in asymptomatic carriers with normal ALT levels (2·5%). Higher values were observed in anti-HBe positive chronic patients (15·8%) and in carriers occasionally found with changes in ALT without any other clinical sign of illness (16·7%). These data would indicate that HBV-DNA is the serological marker which is most closely related to liver disease.

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Copyright

Corresponding author

* M. Rapicetta, Istituto Superiore di Sanità, Department of Virology, V. le Regina Elena, 229-00161, Rome, Italy.

References

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