Skip to main content
    • Aa
    • Aa

Human papillomavirus type-18 prevalence in oesophageal cancer in the Chinese population: a meta-analysis

  • L. W. GUO (a1), S. K. ZHANG (a1), S. Z. LIU (a1), Q. CHEN (a1), M. ZHANG (a1), P. L. QUAN (a1), J. B. LU (a1) and X. B. SUN (a1)...

Globally, the prevalence of oesophageal cancer cases is particularly high in China. Since 1982, oncogenic human papillomavirus (HPV) has been hypothesized as a risk factor for oesophageal cancer, but no firm evidence of HPV infection in oesophageal cancer has been established to date. We aimed to conduct a meta-analysis to estimate the high-risk HPV-18 prevalence of oesophageal cancer in the Chinese population. Eligible studies published from 1 January 2005 to 12 July 2014 were retrieved via computer searches of English and Chinese literature databases (including Medline, EMBASE, Chinese National Knowledge Infrastructure and Wanfang Data Knowledge Service Platform). A random-effects model was used to calculate pooled prevalence and corresponding 95% confidence intervals (CIs). A total of 2556 oesophageal cancer cases from 19 studies were included in this meta-analysis. Overall, the pooled HPV-18 prevalence in oesophageal cancer cases was 4·1% (95% CI 2·7–5·5) in China, 6·1% (95% CI 2·9–9·3) in fresh or frozen biopsies and 4·0% (95% CI 2·3–5·8) in paraffin-embedded fixed biopsies, 8·2% (95% CI 4·6–11·7) by the E6/E7 region and 2·2% (95% CI 0·9–3·6) by the L1 region of the HPV gene. This meta-analysis indicated that China has a moderate HPV-18 prevalence of oesophageal cancer compared to cervical cancer, although there is variation between different variables. Further studies are needed to elucidate the role of HPV in oesophagus carcinogenesis with careful consideration of study design and laboratory detection method, providing more accurate assessment of HPV status in oesophageal cancer.

Corresponding author
*Author for correspondence: Dr X. B. Sun, Department of Cancer Epidemiology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Henan Office for Cancer Control and Research, Dongming Road No. 127, PO Box 0061, Zhengzhou, China 450008. (Email:
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

3. RS Holmes , TL Vaughan . Epidemiology and pathogenesis of esophageal cancer. Seminars in Radiation Oncology 2007; 17: 29.

6. A Ciapponi , Type-specific HPV prevalence in cervical cancer and high-grade lesions in Latin America and the Caribbean: systematic review and meta-analysis. PLoS ONE 2011; 6: e25493.

7. AR Kreimer , Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiology, Biomarkers & Prevention 2005; 14: 467475.

11. T Li , Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of China. Carcinogenesis 2001; 22: 929934.

12. EM de Villiers , Classification of papillomaviruses. Virology 2004; 324: 1727.

14. KJ Syrjanen . HPV infections and oesophageal cancer. Journal of Clinical Pathology 2002; 55: 721728.

15. JL Petrick , Prevalence of human papillomavirus among oesophageal squamous cell carcinoma cases: systematic review and meta-analysis. British Journal of Cancer 2014; 110: 23692377.

17. R DerSimonian , N Laird . Meta-analysis in clinical trials. Controlled Clinical Trials 1986; 7: 177188.

21. X Wang , Detection of HPV DNA in esophageal cancer specimens from different regions and ethnic groups: a descriptive study. BMC Cancer 2010; 10: 19.

26. X Cui , Heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations. Journal of Medical Virology 2014; 86: 608617.

27. XM Lu , Human papillomavirus in esophageal squamous cell carcinoma of the high-risk Kazakh ethnic group in Xinjiang, China. European Journal of Surgical Oncology 2008; 34: 765770.

29. M Dai , Human papillomavirus infection among 100 oesophageal cancer cases in the People's Republic of China. International Journal of Cancer 2007; 121: 13961398.

30. F Guo , Human papillomavirus infection and esophageal squamous cell carcinoma: a case-control study. Cancer Epidemiology, Biomarkers & Prevention 2012; 21: 780785.

32. B Cao , LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China. Carcinogenesis 2005; 26: 12801284.

33. J Koshiol , No role for human papillomavirus in esophageal squamous cell carcinoma in China. International Journal of Cancer 2010; 127: 93100.

34. HY Liu , Prevalence of human papillomavirus infection in esophageal and cervical cancers in the high incidence area for the two diseases from 2007 to 2009 in Linzhou of Henan Province, Northern China. Archives of Virology 2014; 159: 13931401.

37. T Liu , Viral load of HPV 16/18 in esophageal squamous cell carcinoma in three ethnic groups living in Xinjiang Autonomous Region, China. Molecular Biology Reports 2013; 40: 20452052.

41. N Li , Human papillomavirus infection and bladder cancer risk: a meta-analysis. Journal of Infectious Diseases 2011; 204: 217223.

43. F Kamangar , Human papillomavirus serology and the risk of esophageal and gastric cancers: results from a cohort in a high-risk region in China. International Journal of Cancer 2006; 119: 579584.

44. M Poljak , A Cerar , K Seme . Human papillomavirus infection in esophageal carcinomas: a study of 121 lesions using multiple broad-spectrum polymerase chain reactions and literature review. Human Pathology 1998; 29: 266271.

46. S Garcia-Vallve , A Alonso , IG Bravo . Papillomaviruses: different genes have different histories. Trends in Microbiology 2005; 13: 514521.

47. K Munger , PM Howley . Human papillomavirus immortalization and transformation functions. Virus Research 2002; 89: 213228.

48. CM Hebner , LA Laimins . Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity. Reviews in Medical Virology 2006; 16: 8397.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Full text views

Total number of HTML views: 2
Total number of PDF views: 27 *
Loading metrics...

Abstract views

Total abstract views: 193 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 26th June 2017. This data will be updated every 24 hours.