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Infection with influenza A H1N1: 2. The effect of past experience on natural challenge

  • J. R. Davies (a1), E. A. Grilli (a1) and A. J. Smith (a1)
  • DOI:
  • Published online: 19 October 2009

Following its reintroduction in 1978 influenza A H1N1 spread widely in the child population. By the autumn of 1979, 75% of 11-year olds entering a boys' boarding school had detectable antibody. The protective effect of previous experience could be assessed during two outbreaks in the school. In the first outbreak in 1979, 90% of those known to have been infected in the previous year were protected against reinfection. In 1983 after strains of the H1N1 subtype had undergone antigenic drift a large outbreak occurred. It was estimated that past infection conferred protection against clinical influenza in 55%. Where past infection resulted in the presence of antibody which reacted with the outbreak strain the attack rate was further reduced. A large number of sub-clinical infections was detected in all groups.

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J. R. Davies , A. J. Smith , E. A. Grilli & T. W. Hoskins (1982). Christ's Hospital 1978–79: an account of two outbreaks of influenza A H1N1. Journal of Infection 5, 151156.

B. J. Feery , H. A. Gallichio , S. J. Rodda & A. W. Hampson (1979). Antibody responses to influenza vaccines containing A/USSR/90/77. Australian Journal of Experimental Biology and Medical Science 57, 335344.

C. W. Potter , A. Clark , R. Jennings , G. C. Schild , J. M. Wood & P. K. A. McWilliam (1980). Reactogenicity and immunogenicity of inactivated influenza A (H1N1) virus vaccine in unprimed children. Journal of Biological Standardization 8, 3548.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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