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Infection with influenza A H1N1: 2. The effect of past experience on natural challenge

  • J. R. Davies (a1), E. A. Grilli (a1) and A. J. Smith (a1)
Summary
SUMMARY

Following its reintroduction in 1978 influenza A H1N1 spread widely in the child population. By the autumn of 1979, 75% of 11-year olds entering a boys' boarding school had detectable antibody. The protective effect of previous experience could be assessed during two outbreaks in the school. In the first outbreak in 1979, 90% of those known to have been infected in the previous year were protected against reinfection. In 1983 after strains of the H1N1 subtype had undergone antigenic drift a large outbreak occurred. It was estimated that past infection conferred protection against clinical influenza in 55%. Where past infection resulted in the presence of antibody which reacted with the outbreak strain the attack rate was further reduced. A large number of sub-clinical infections was detected in all groups.

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References
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Davies J. R., Smith A. J., Grilli E. A. & Hoskins T. W. (1982). Christ's Hospital 1978–79: an account of two outbreaks of influenza A H1N1. Journal of Infection 5, 151156.
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Grilli E. A., Davies J. R. & Smith A. J. (1980). Infection with influenza A H1N1. 1. Production and persistence of antibody. Journal of Hygiene 96, 335343.
Hoskins T. W., Davies J. R., Smith A. J., Miller C. L. & Allchin A. (1979). Assessment of influenza A vaccine after three outbreaks of influenza A at Christ's Hospital. Lancet i, 3335.
Potter C. W., Clark A., Jennings R., Schild G. C., Wood J. M. & McWilliam P. K. A. (1980). Reactogenicity and immunogenicity of inactivated influenza A (H1N1) virus vaccine in unprimed children. Journal of Biological Standardization 8, 3548.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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