Skip to main content
×
Home
    • Aa
    • Aa

Investigation of tick-borne viruses as pathogens of humans in South Africa and evidence of Dugbe virus infection in a patient with prolonged thrombocytopenia

  • F. J. Burt (a1), D. C. Spencer (a2), P. A. Leman (a1), B. Patterson (a1) and R. Swanepoel (a1)...
Abstract
SUMMARY

In the course of investigating suspected cases of viral haemorrhagic fever in South Africa patients were encountered who had been bitten by ticks, but who lacked evidence of infection with Crimean–Congo haemorrhagic fever (CCHF) virus or non-viral tick-borne agents. Cattle sera were tested by enzyme-linked immunoassay to determine whether tick-borne viruses other than CCHF occur in the country. The prevalence of antibody in cattle sera was 905/2116 (42·8%) for CCHF virus, 70/1358 (5·2%) for Dugbe, 21/1358 (1·5%) for louping ill, 6/450 (1·3%) for West Nile, 7/1358 (0·5%) for Nairobi sheep disease, 3/625 (0·5%) for Kadam and 2/450 (0·4%) for Chenuda. No reactions were recorded with Hazara, Bahig, Bhanja, Thogoto and Dhori viruses. The CCHF findings confirmed previous observations that the virus is widely prevalent within the distribution range of ticks of the genus Hyalomma, while antibody activity to Dugbe antigen was detected only within the distribution range of the tick Amblyomma hebraeum. Cross-reactivity for the nairoviruses, Hazara, Nairobi sheep disease and Dugbe, was detected in serum samples from 3/72 human patients with confirmed CCHF infection, and serum from 1/162 other patients reacted monospecifically with Dugbe antigen. The latter patient suffered from febrile illness with prolonged thrombocytopenia.

Copyright
Corresponding author
* Author for correspondence: F. J. Burt, National Institute for Virology, Private Bag X4, Sandringham 2131, South Africa.
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

3. R Swanepoel , DE Gill , AJ Shepherd , PA Leman , JH Mynhardt , S Harvey . The clinical pathology of Crimean–Congo haemorrhagic fever. Rev Infect Dis 1989; 11: S794800.

12. VK Ward , AC Marriott , TF Booth , Ghorr El , PA Nuttall . Detection of an arbovirus in an invertebrate host using the polymerase chain reaction. J Virol Methods 1990; 30: 291300.

13. J Casals , GH Tignor . Neutralisation and hemagglutination-inhibition tests with Crimean hemorrhagic fever-Congo virus. Proc Soc Exp Biol Med 1974; 145: 960–6.

14. AJ Shepherd , R Swanepoel , PA Leman . Antibody response in Crimean–Congo hemorrhagic fever. Rev Infect Dis 1989; 11: S8016.

19. AJ Georges , JL Lesbordes , MC Georges-Courbot , DMY Meunier , JP Gonzalez . Fatal hepatitis from West Nile virus. Ann Inst Pasteur/Virol 1987; 138: 237–44.

21. VK Ward , AC Marriott , T Polyzoni , AA El-Ghorr , A Antoniadis , PA Nuttall . Expression of the nucleocapsid protein of Dugbe virus and antigenic cross-reactions with other nairoviruses. Virus Res 1992; 24: 223–29.

22. J Casals , GH Tignor . The Nairovirus genus: serological relationships. Intervirology 1980; 14: 144–7.

23. FG Davies , DM Jesset , S Otieno . The antibody response of sheep following infection with Nairobi sheep disease virus. J Comp Pathol 1976; 86: 497502.

25. DL Moore , OR Causey , DE Carey , Arthropod-borne viral infections of man in Nigeria, 1964–1970. Ann Trop Med Parasitol 1975; 69: 4964.

29. FG Davies , J Mungai , T Shaw . A Nairobi sheep disease vaccine. Vet Record 1974; 94: 1280.

30. RM Edelsten . The distribution and prevalence of Nairobi sheep disease and other tick-borne infections of sheep and goats in northern Somalia. Trop Anim Hlth Prod 1975; 7: 2934.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 2 *
Loading metrics...

Abstract views

Total abstract views: 34 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 24th May 2017. This data will be updated every 24 hours.