Skip to main content
×
Home
    • Aa
    • Aa

Outbreak of gastroenteritis caused by Yersinia pestis in Afghanistan

  • T. LESLIE (a1) (a2), C. A. WHITEHOUSE (a3), S. YINGST (a3), C. BALDWIN (a3), F. KAKAR (a4), J. MOFLEH (a4), A. S. HAMI (a1), L. MUSTAFA (a4), F. OMAR (a4), E. AYAZI (a4), C. ROSSI (a3), B. NOORMAL (a4), N. ZIAR (a4) and R. KAKAR (a5)...
Summary
SUMMARY

Plague, which is most often caused by the bite of Yersinia pestis-infected fleas, is a rapidly progressing, serious disease that can be fatal without prompt antibiotic treatment. In late December 2007, an outbreak of acute gastroenteritis occurred in Nimroz Province of southern Afghanistan. Of the 83 probable cases of illness, 17 died (case fatality 20·5%). Being a case was associated with consumption or handling of camel meat (adjusted odds ratio 4·4, 95% confidence interval 2·2–8·8, P<0·001). Molecular testing of patient clinical samples and of tissue from the camel using PCR/electrospray ionization–mass spectrometry revealed DNA signatures consistent with Yersinia pestis. Confirmatory testing using real-time PCR and immunological seroconversion of one of the patients confirmed that the outbreak was caused by plague, with a rare gastrointestinal presentation. The study highlights the challenges of identifying infectious agents in low-resource settings; it is the first reported occurrence of plague in Afghanistan.

Copyright
Corresponding author
*Author for correspondence: Dr T. Leslie, Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT, UK. (Email: toby.leslie@lshtm.ac.uk)
References
Hide All
15. U Wernery , O-R Kaaden . Infectious Diseases in Camelids, 2nd edn.Berlin: Blackwell Wissenschafts-Verlag, 2002.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 16
Total number of PDF views: 21 *
Loading metrics...

Abstract views

Total abstract views: 228 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 17th October 2017. This data will be updated every 24 hours.