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Secretor status, smoking and carriage of Neisseria meningitidis

  • C. C. Blackwell (a1), D. M. Weir (a1), V. S. James (a1), W. T. A. Todd (a2), N. Banatvala (a2), A. K. R. Chaudhuri (a2), H. G. Gray (a3), E. J. Thomson (a4) and R. J. Fallon (a5)...
Summary
SUMMARY

A survey of ABO blood groups, secretor status and smoking habits among 389 students and staff of a school in which there was an outbreak of meningococcal disease found no difference in the distribution of the ABO blood groups but a significantly higher proportion of non-secretors (37·6%) in the population examined compared with that reported for previous surveys of the neighbouring population in Glasgow (26·2%) (P < 0·0005). There was also a significantly higher proportion of non-secretors among carriers of meningococci (47%) compared with non-carriers (32%). Increased carriage of meningococci among non-secretors might contribute to the increased susceptibility of individuals with this genetic characteristic to meningococcal disease observed in previous studies. Although passive exposure to cigarette smoke has been associated with meningococcal disease, there was no association between passive smoking and carriage. There was, however, a significant association between active smoking and carriage.

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References
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CC Blackwell , K Jonsdottir , I Mohammed , DM Weir . Non-secretion of blood group antigens – a genetic factor predisposing to infection by Neisseria meningitidis. In JT Poolman ed., , Gonococci and meningococci. Dordrecht: Kluwer Academic Publishers, 1988.

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DF Kinane , CC Blackwell , RP Brettle , DM Weir , FP Winstanley , RA Elton . Blood group secretor state and susceptibility to recurrent urinary tract infections in women. Br Med J 1982; 285: 79.

MP MacSween , UA Syme . ABO blood groups and skin diseases. Brit J Dermatol 1965; 77: 30–4.

AP Burford-Mason , JCP Weber , JMT Willoughby . Oral carriage of Candida albicans, ABO blood group and secretor status in healthy individuals. J Med Vet Mycol 1988; 26: 4956.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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