Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 8
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Bado, Inés Gutiérrez, Claudia García-Fulgueiras, Virginia Cordeiro, Nicolás F. Araújo Pirez, Lucía Seija, Verónica Bazet, Cristina Rieppi, Gloria and Vignoli, Rafael 2016. CTX-M-15 in combination with aac(6′)-Ib-cr is the most prevalent mechanism of resistance both in Escherichia coli and Klebsiella pneumoniae, including K. pneumoniae ST258, in an ICU in Uruguay. Journal of Global Antimicrobial Resistance, Vol. 6, p. 5.

    Doyle, Marjorie E. 2015. Multidrug-Resistant Pathogens in the Food Supply. Foodborne Pathogens and Disease, Vol. 12, Issue. 4, p. 261.

    Ludden, Catherine Cormican, Martin Vellinga, Akke Johnson, James R Austin, Bernie and Morris, Dearbháile 2015. Colonisation with ESBL-producing and carbapenemase-producing Enterobacteriaceae, vancomycin-resistant enterococci, and meticillin-resistant Staphylococcus aureus in a long-term care facility over one year. BMC Infectious Diseases, Vol. 15, Issue. 1,

    Nematzadeh, Shoeib Shahcheraghi, Fereshteh Iversen, Aina and Giske, Christian G. 2015. Successful international clones of blaCTX-M-15–producing Klebsiella pneumoniae with coexpression of plasmid-mediated quinolone resistance (PMQR) determinants in Tehran hospitals. Diagnostic Microbiology and Infectious Disease, Vol. 83, Issue. 4, p. 371.

    Cattoir, Vincent and Dowzicky, Michael J 2014. A longitudinal assessment of antimicrobial susceptibility among important pathogens collected as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) in France between 2004 and 2012. Antimicrobial Resistance and Infection Control, Vol. 3, Issue. 1, p. 36.

    Compain, Fabrice Decré, Dominique Fulgencio, Jean-Pierre Berraho, Sfia Arlet, Guillaume and Verdet, Charlotte 2014. Molecular characterization of DHA-1–producing Klebsiella pneumoniae isolates collected during a 4-year period in an intensive care unit. Diagnostic Microbiology and Infectious Disease, Vol. 80, Issue. 2, p. 159.

    Freeman, Joshua T Rubin, Joseph McAuliffe, Gary N Peirano, Gisele Roberts, Sally A Drinković, Dragana and Pitout, Johann DD 2014. Differences in risk-factor profiles between patients with ESBL-producing Escherichia coli and Klebsiella pneumoniae: a multicentre case-case comparison study. Antimicrobial Resistance and Infection Control, Vol. 3, Issue. 1, p. 27.

    Wrenn, C. O'Brien, D. Keating, D. Roche, C. Rose, L. Ronayne, A. Fenelon, L. Fitzgerald, S. Crowley, B. and Schaffer, K. 2014. Investigation of the first outbreak of OXA-48-producing Klebsiella pneumoniae in Ireland. Journal of Hospital Infection, Vol. 87, Issue. 1, p. 41.


The emergence of multidrug-resistant Klebsiella pneumoniae of international clones ST13, ST16, ST35, ST48 and ST101 in a teaching hospital in the Paris region

  • G. MARCADE (a1), S. BRISSE (a2), S. BIALEK (a3) (a4) (a5), E. MARCON (a3), V. LEFLON-GUIBOUT (a3), V. PASSET (a2), R. MOREAU (a5) and M.-H. NICOLAS-CHANOINE (a3) (a4) (a5)
  • DOI:
  • Published online: 04 October 2012

Despite infection control measures, an important increase in the extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae incidence density occurred in our hospital from 2006 onwards. This study, focusing on the 2005–2007 period, was performed in an attempt to explain this increase. ESBLs were characterized, isolates were typed by ERIC2-PCR, and sequence type (ST) of clustered isolates was determined. Temporal-spatial relationships of patients were analysed to assess possible cross-contamination. Of the 74 ESBL-producing isolates, 30 (40%) were detected at admission, 53 (71·5%) produced CTX-M enzymes, 40 displayed unique ERIC2-PCR profiles and 34 were assigned into six clusters: ST16 (n = 21), ST101, ST48, ST35, ST13, and ST436. Relationships were identified in 22 of the 34 patients harbouring clustered isolates. This study highlights the complex epidemiology of ESBL-producing K. pneumoniae in the mid-2000s with potential cross-contamination for only 30% of the 74 patients in our hospital, and the emergence of clones that are currently spreading worldwide.

Corresponding author
*Author for correspondence: Professor M.-H. Nicolas-Chanoine, Service de Microbiologie, Hôpital Beaujon, 92110 Clichy, France. (Email:
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1.R Cantón , Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe. Clinical Microbiology and Infection 2008; 14 (Suppl. 1): 144153.

4.TR Walsh . Clinically significant carbapenemases: an update. Current Opinion in Infectious Diseases 2008; 21: 367371.

6.M-H Nicolas-Chanoine , Intercontinental emergence of Escherichia coli clone O25:H4-ST131 producing CTX-M-15. Journal of Antimicrobial Chemotherapy 2008; 61: 273281.

9.L Diancourt , Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. Journal of Clinical Microbiology 2005; 43: 41784182.

16.P Gastmeier , A cluster of nosocomial Klebsiella pneumoniae bloodstream infections in a neonatal intensive care department: identification of transmission and intervention. American Journal of Infection Control 2003; 31: 424430.

17.M Blanco , Molecular epidemiology of Escherichia coli producing extended-spectrum beta-lactamases in Lugo (Spain): dissemination of clone O25b:H4-ST131 producing CTX-M-15. Journal of Antimicrobial Chemotherapy 2009; 63: 11351141.

20.CH Lester , Emergence of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae in Danish hospitals; this is in part explained by spread of two CTX-M-15 clones with multilocus sequence types 15 and 16 in Zealand. International Journal of Antimicrobial Agents 2011; 38: 180182.

22.LN Andrade , Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil. Antimicrobial Agents and Chemotherapy 2011; 55: 35793583.

23.J Oteo , Emergence of CTX-M-15-producing Klebsiella pneumoniae of multilocus sequence types 1, 11, 14, 17, 20, 35 and 36 as pathogens and colonizers in newborns and adults. Journal of Antimicrobial Chemotherapy 2009; 64: 524528.

25.P Giakkoupi , An update of the evolving epidemic of blaKPC-2-carrying Klebsiella pneumoniae in Greece (2009–10). Journal of Antimicrobial Chemotherapy 2011; 66: 15101513.

26.S Brisse , Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. PLoS One 2009; 4: e4982.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *