Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 5
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Velji, Preya Nikolayevskyy, Vladyslav Brown, Timothy and Drobniewski, Francis 2009. Discriminatory Ability of Hypervariable Variable Number Tandem Repeat Loci in Population-based Analysis ofMycobacterium tuberculosisStrains, London, UK. Emerging Infectious Diseases, Vol. 15, Issue. 10, p. 1609.

    Shingadia, Delane and Burgner, David 2008. Pediatric Respiratory Medicine.

    ANYAMA, N. BRACEBRIDGE, S. BLACK, C. NIGGEBRUGGE, A. and GRIFFIN, S. J. 2007. What happens to people diagnosed with tuberculosis? A population-based cohort. Epidemiology and Infection, Vol. 135, Issue. 07,

    2006. Beijing/W GenotypeMycobacterium tuberculosisand Drug Resistance. Emerging Infectious Diseases, Vol. 12, Issue. 5, p. 736.

    Walls, Tony and Shingadia, Delane 2004. Global epidemiology of paediatric tuberculosis. Journal of Infection, Vol. 48, Issue. 1, p. 13.


The molecular epidemiology of tuberculosis in inner London

  • A. C. HAYWARD (a1), S. GOSS (a2), F. DROBNIEWSKI (a2), N. SAUNDERS (a3), R. J. SHAW (a4), M. GOYAL (a5), A. SWAN (a6), A. UTTLEY (a2), A. POZNIAK (a7), J. GRACE-PARKER (a8) and J. M. WATSON (a8)
  • DOI:
  • Published online: 01 April 2002

The study used DNA fingerprint typing (spoligotyping and Heminested-Inverse-PCR) of Mycobacterium tuberculosis from all culture-confirmed inner London patients over a 12-month period to describe transmission. The methodology was evaluated by comparison with standard IS6110 typing and by examining its ability to identify known household clusters of cases. Isolates sharing indistinguishable typing patterns using both techniques were defined as clustered. Clusters were investigated to identify epidemiological links. The methodology showed good discriminatory power and identified known household clusters of cases. Of 694 culture-confirmed cases, 563 (81%) were typed. Eleven (2%) were due to laboratory cross-contamination and were excluded. Of the remaining 552 isolates 148 (27%) were clustered. Multivariate analysis indicated that clustering was more common in those with pulmonary smear positive disease (P<0·02); those born in the United Kingdom (P<0·0003) and in patients living in south London (P = 0·02). There was also a trend towards clustering being more common in those not known to have HIV infection (P = 0·051). The results suggest that in inner London, recent local transmission makes an important contribution to notification rates.

Corresponding author
Author for correspondence.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *