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Effects of different doses of oral ketamine for premedication of children

  • S. Turhanoğlu (a1), A. Kararmaz (a1), M. A. Özyilmaz (a1), S. Kaya (a1) and D. Tok (a1)...


Background and objective: A need exists for a safe and effective oral preanaesthetic medication for use in children undergoing elective surgery. The study sought to define the dose of oral ketamine that would facilitate induction of anaesthesia without causing significant side-effects.

Methods: We studied 80 children undergoing elective surgery under general anaesthesia who received oral ketamine 4, 6 or 8 mg kg−1 in a prospective, randomized, double-blind placebo controlled study. We compared the reaction to separation from parents, transport to the operating room, the response to intravenous cannula insertion and application of an anaesthetic facemask, the induction of anaesthesia and recovery from anaesthesia.

Results: In the group receiving ketamine 8 mg kg−1, the children were significantly calmer than those of the other groups, and anaesthesia induction was more comfortable. Recovery from anaesthesia was longer in the group receiving ketamine 8 mg kg−1 compared with the other groups, but no differences between the groups were observed after 2 h in the recovery room.

Conclusions: It is concluded that oral ketamine 8 mg kg−1 is an effective oral premedication in inpatient children undergoing elective surgery.

Corresponding author
Correspondence to: Selim Turhanoğlu, Dicle University Hospital, Department of Anaesthesiology, Diyarbakir, Turkey. E-mail:
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Weldon BC, Watcha MF, White PF. Oral midazolam in children: effect of time and adjunctive therapy. Anesth Analg 1992; 75: 5155.
Gutstein HB, Johnson KL, Heard MB, Gregory GA. Oral ketamine preanesthetic medication in children. Anesthesiology 1992; 76: 2833.
Kluger MT, Owen H. Premedication: an audit. Anaesthesia 1991; 46: 224227.
White PF, Ham J, Way WL, Trevor AJ. Pharmacology of ketamine isomers in surgical patients. Anesthesiology 1980; 52: 231239.
Petros AJ. Oral ketamine: its use for mentally retarded adults requiring day case dental treatment. Anaesthesia 1991; 46: 646647.
Grant IS, Nimmo WS, Clements JA. Pharmacokinetics and analgesic effects of im and oral ketamine. Br J Anaesth 1981; 53: 805810.
Sekerci C, Dönmez A, Ates Y, Okten F. Oral ketamine premedication in children (placebo controlled double-blind study). Eur J Anaesthesiol 1996; 13: 606611.
Tobias JD, Phipps S, Smith B, Mulhern RK. Oral ketamine premedication to alleviate the distress of invasive procedures in paediatric oncology patients. Pediatrics 1992; 90: 537541.
Warner DL, Cabaret J, Velling D. Ketamine plus midazolam, a most effective paediatric oral premedicant. Paediatr Anaesth 1995; 5: 293295.
Clements JA, Nimmo WS, Grant IS. Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans. J Pharm Sci 1982; 71: 539542.
Feld LH, Negus JB, White PF. Oral midazolam preanesthetic medication in paediatric outpatients. Anesthesiology 1990; 73: 831834.
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European Journal of Anaesthesiology
  • ISSN: 0265-0215
  • EISSN: 1365-2346
  • URL: /core/journals/european-journal-of-anaesthesiology
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