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Increased Affective Reactivity to Neutral Stimuli and Decreased Maintenance of Affective Responses in Bipolar Disorder

Published online by Cambridge University Press:  16 April 2020

M. Lemaire ,
W. El-Hage  and
S. Frangou
M. Lemaire
Affiliation:
UMR Inserm U930, University François-Rabelais, Tours, France CHRU Tours, Department of Child Psychiatry, Tours, France
W. El-Hage
Affiliation:
UMR Inserm U930, University François-Rabelais, Tours, France CHRU Tours, Department of Adult Psychiatry (CPU), Tours, France
S. Frangou*
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, USA
*
*Corresponding author. Tel.: +212 659 1668; fax: +212 659 8576. E-mail address: sophia.frangou@mssm.edu (S. Frangou).
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Abstract

Background:

Affective dysregulation is a core feature of bipolar disorder (BD) and a significant predictor of clinical and functional outcome. Affective dysregulation can arise from abnormalities in multiple processes. This study addresses the knowledge gap regarding the precise nature of the processes that may be dysregulated in BD and their relationship to the clinical expression of the disorder.

Methods:

Patients with BD (n = 45) who were either in remission or in a depressive or manic state and healthy individuals (n = 101) were compared in terms of the intensity, duration and physiological response (measured using inter-beat intervals and skin conductance) to affective and neutral pictures during passive viewing and during experiential suppression.

Results:

Compared to healthy individuals, patients with BD evidenced increased affective reactivity to neutral pictures and reduced maintenance of subjective affective responses to all pictures. This pattern was present irrespective of clinical state but was more pronounced in symptomatic patients, regardless of polarity. Patients, regardless of symptomatic status, were comparable to healthy individuals in terms of physiological arousal and voluntary control of affective responses.

Conclusion:

Our study demonstrates that increased affective reactivity to neutral stimuli and decreased maintenance of affective responses are key dimensions of affective dysregulation in BD.

Keywords

Bipolar disorderAffective dysregulationGalvanic skin responseHeart rateArousal
Type
Original article
Information
European Psychiatry , Volume 30 , Issue 7 , October 2015 , pp. 852 - 860
Copyright
European Psychiatric Association 2015

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