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Plasma-based proteomics reveals lipid metabolic and immunoregulatory dysregulation in post-stroke depression

Published online by Cambridge University Press:  15 April 2020

Y. Zhan ,
Y.-T. Yang ,
H.-M. You ,
D. Cao ,
C.-Y. Liu ,
C.-J. Zhou ,
Z.-Y. Wang ,
S.-J. Bai ,
J. Mu  and
B. Wu
...Show all authors
Y. Zhan
Affiliation:
Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
Y.-T. Yang
Affiliation:
Department of Neurology, The First Affiliated Hospital at Chongqing Medical University, 1, Yixue Road, Yuzhong District, Chongqing, 400016, China Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
H.-M. You
Affiliation:
Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
D. Cao
Affiliation:
Department of Neurology, The First Affiliated Hospital at Chongqing Medical University, 1, Yixue Road, Yuzhong District, Chongqing, 400016, China Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
C.-Y. Liu
Affiliation:
Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
C.-J. Zhou
Affiliation:
Department of Neurology, The First Affiliated Hospital at Chongqing Medical University, 1, Yixue Road, Yuzhong District, Chongqing, 400016, China Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
Z.-Y. Wang
Affiliation:
Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
S.-J. Bai
Affiliation:
Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
J. Mu
Affiliation:
Department of Neurology, The First Affiliated Hospital at Chongqing Medical University, 1, Yixue Road, Yuzhong District, Chongqing, 400016, China Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
B. Wu
Affiliation:
Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
Q.-L. Zhan
Affiliation:
Department of Neurology, The Fifth People's Hospital of Chongqing, Chongqing, China
P. Xie*
Affiliation:
Department of Neurology, The First Affiliated Hospital at Chongqing Medical University, 1, Yixue Road, Yuzhong District, Chongqing, 400016, China Chongqing Key Laboratory of Neurobiology, Chongqing, China Institute of Neuroscience, Chongqing Medical University, Chongqing, China
*
*Corresponding author. Tel.: +86 23 68485490; fax: +86 23 68485111. E-mail address:xiepeng@cqmu.edu.cn (P. Xie).
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Abstract

Background:

Post-stroke depression (PSD) is the most common psychiatric complication facing stroke survivors and has been associated with increased distress, physical disability, poor rehabilitation, and suicidal ideation. However, the pathophysiological mechanisms underlying PSD remain unknown, and no objective laboratory-based test is available to aid PSD diagnosis or monitor progression.

Methods:

Here, an isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomic approach was performed to identify differentially expressed proteins in plasma samples obtained from PSD, stroke, and healthy control subjects.

Results:

The significantly differentiated proteins were primarily involved in lipid metabolism and immunoregulation. Six proteins associated with these processes – apolipoprotein A-IV (ApoA-IV), apolipoprotein C-II (ApoC-II), C-reactive protein (CRP), gelsolin, haptoglobin, and leucine-rich alpha-2-glycoprotein (LRG) – were selected for Western blotting validation. ApoA-IV expression was significantly upregulated in PSD as compared to stroke subjects. ApoC-II, LRG, and CRP expression were significantly downregulated in both PSD and HC subjects relative to stroke subjects. Gelsolin and haptoglobin expression were significantly dysregulated across all three groups with the following expression profiles: gelsolin, healthy control > PSD > stroke subjects; haptoglobin, stroke > PSD > healthy control.

Conclusions:

Early perturbation of lipid metabolism and immunoregulation may be involved in the pathophysiology of PSD. The combination of increased gelsolin levels accompanied by decreased haptoglobin levels shows promise as a plasma-based diagnostic biomarker panel for detecting increased PSD risk in post-stroke patients.

Keywords

Post-stroke depressionPSDStrokePlasmaProteomic
Type
Original articles
Information
European Psychiatry , Volume 29 , Issue 5 , June 2014 , pp. 307 - 315
Copyright
Copyright © Elsevier Masson SAS 2014

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Footnotes

1

These authors contributed equally to this study.

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