Hostname: page-component-848d4c4894-m9kch Total loading time: 0 Render date: 2024-05-03T17:47:06.627Z Has data issue: false hasContentIssue false
  • English
  • Français

An fMRI study of emotional face encoding in youth at risk for bipolar disorder

Published online by Cambridge University Press:  15 April 2020

W.-L. Tseng ,
B.L. Bones ,
R.R. Kayser ,
A.K. Olsavsky ,
S.J. Fromm ,
D.S. Pine ,
E. Leibenluft  and
M.A. Brotman
W.-L. Tseng*
Affiliation:
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
B.L. Bones
Affiliation:
Georgetown University School of Medicine, Washington, DC, USA.
R.R. Kayser
Affiliation:
Georgetown University School of Medicine, Washington, DC, USA.
A.K. Olsavsky
Affiliation:
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
S.J. Fromm
Affiliation:
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
D.S. Pine
Affiliation:
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
E. Leibenluft
Affiliation:
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
M.A. Brotman
Affiliation:
Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
*
* Corresponding author at: Building 15K Room 208, MSC 2670, 15K North Drive, Bethesda, MD 20892, USA. E-mail address:wan-ling.tseng@nih.gov (W.-L. Tseng).
Get access

Abstract

Face memory deficits may be a bipolar disorder (BD) endophenotype. BD (n = 27) and unaffected youth at risk (n = 13) exhibited middle frontal gyrus hypoactivation during successful vs. unsuccessful encoding. Parahippocampal gyrus dysfunction was found in BD and at-risk youth (vs. low-risk, n = 37). Middle occipital gyrus hypoactivation was only present in BD.

Keywords

fMRIPediatric bipolar disorderAt riskFace memoryEndophenotype
Type
Short communication
Information
European Psychiatry , Volume 30 , Issue 1 , January 2015 , pp. 94 - 98
Copyright
Copyright © European Psychiatric Association 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adleman, NE, Kayser, RR, Olsavsky, AK, Bones, BL, Muhrer, EJ, Fromm, SJ, et al.Abnormal fusiform activation during emotional face encoding assessed with functional magnetic resonance imaging. Psychiatry Res 2013; 212: 161–163CrossRefGoogle ScholarPubMed
Brotman, MA, Guyer, AE, Lawson, ES, Horsey, SE, Rich, BA, Dickstein, DP, et al.Facial emotion labeling deficits in children and adolescents at-risk for bipolar disorder. Am J Psychiatry 2008; 165: 385–389CrossRefGoogle ScholarPubMed
Brotman, MA, Rooney, MH, Skup, M, Pine, DS, Leibenluft, EIncreased intrasubject variability in response time in youths with bipolar disorder and at-risk family members. J Am Acad Child Adolesc Psychiatry 2009; 48: 628–635CrossRefGoogle ScholarPubMed
Dickstein, DP, Rich, BA, Roberson-Nay, R, Berghorst, L, Vinton, D, Pine, DS, et al.Neural activation during encoding of emotional faces in pediatric bipolar disorder. Bipolar Disord 2007; 9: 679–692CrossRefGoogle ScholarPubMed
Eichenbaum, H, Yonelinas, AP, Ranganath, CThe medial temporal lobe and recognition memory. Annu Rev Neurosci 2007; 30: 123–152CrossRefGoogle ScholarPubMed
Garavan, H, Ross, TJ, Li, SJ, Stein, EAA parametric manipulation of central executive functioning. Cereb Cortex 2000; 10: 585–592CrossRefGoogle ScholarPubMed
Glahn, DC, Almasy, L, Barguil, M, Hare, E, Peralta, JM, Kent, JW Jr., et al.Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. Arch Gen Psychiatry 2010; 67: 168–177CrossRefGoogle ScholarPubMed
Glahn, DC, Robinson, JL, Tordesillas-Gutierrez, D, Monkul, ES, Holmes, MK, Green, MJ, et al.Fronto-temporal dysregulation in asymptomatic bipolar I patients: a paired associate functional MRI study. Hum Brain Mapp 2010; 31: 1041–1051CrossRefGoogle ScholarPubMed
Gusnard, DA, Raichle, MESearching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci 2001; 2: 685–694CrossRefGoogle ScholarPubMed
Leibenluft, E, Charney, DS, Towbin, KE, Bhangoo, RK, Pine, DSDefining clinical phenotypes of juvenile mania. Am J Psychiatry 2003; 160: 430–437CrossRefGoogle ScholarPubMed
Lieberman, MD, Cunningham, WAType I and type II error concerns in fMRI research: re-balancing the scale. Soc Cogn Affect Neurosci 2009; 4: 423–428CrossRefGoogle ScholarPubMed
McClure, EB, Treland, JE, Snow, J, Dickstein, DP, Towbin, KE, Charney, DS, et al.Memory and learning in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 2005; 44: 461–469CrossRefGoogle ScholarPubMed
Poznanski, EO, Grossman, JA, Buchsbaum, Y, Banegas, M, Freeman, L, Gibbons, RPreliminary studies of the reliability and validity of the children's depression rating scale. J Am Acad Child Psychiatry 1984; 23: 191–197CrossRefGoogle ScholarPubMed
Research on Pediatric Psychopharmacology Anxiety Study Group The Pediatric Anxiety Rating Scale (PARS): development and psychometric properties. J Am Acad Child Adolesc Psychiatry 2002; 41: 1061–1069.CrossRefGoogle Scholar
Shaffer, D, Gould, MS, Brasic, J, Ambrosini, P, Fisher, P, Bird, H, et al.A children's global assessment scale (CGAS). Arch Gen Psychiatry 1983; 40: 1228–1231CrossRefGoogle Scholar
Thomas, LA, Brotman, MA, Bones, BL, Chen, G, Rosen, BH, Pine, DS, et al.Neural circuitry of masked emotional face processing in youth with bipolar disorder, severe mood dysregulation, and healthy volunteers. Dev Cogn Neurosci 2014; 8: 110–120CrossRefGoogle ScholarPubMed
Young, RC, Biggs, JT, Ziegler, VE, Meyer, DAA rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978; 133: 429–435CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.