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Are eye movement abnormalities indicators of genetic vulnerability to schizophrenia?

Published online by Cambridge University Press:  16 April 2020

C. Boudet ,
M.L. Bocca ,
B. Chabot ,
P. Delamillieure ,
P. Brazo ,
P. Denise  and
S. Dollfus
C. Boudet
Affiliation:
Groupe d'imagerie neurofonctionnelle (GIN), UMR 6194, CNRS/CEA/Université de Caen/Université Paris-V, centre Cyceron, boulevard H.-Becquerel, 14000Caen, France
M.L. Bocca
Affiliation:
Service d'explorations fonctionnelles, centre hospitalier et universitaire de Caen, 14033Caen cedex, France
B. Chabot
Affiliation:
Centre Esquirol, centre hospitalier et universitaire de Caen, 14033Caen, France
P. Delamillieure
Affiliation:
Groupe d'imagerie neurofonctionnelle (GIN), UMR 6194, CNRS/CEA/Université de Caen/Université Paris-V, centre Cyceron, boulevard H.-Becquerel, 14000Caen, France Centre Esquirol, centre hospitalier et universitaire de Caen, 14033Caen, France
P. Brazo
Affiliation:
Groupe d'imagerie neurofonctionnelle (GIN), UMR 6194, CNRS/CEA/Université de Caen/Université Paris-V, centre Cyceron, boulevard H.-Becquerel, 14000Caen, France Centre Esquirol, centre hospitalier et universitaire de Caen, 14033Caen, France
P. Denise
Affiliation:
Service d'explorations fonctionnelles, centre hospitalier et universitaire de Caen, 14033Caen cedex, France
S. Dollfus*
Affiliation:
Groupe d'imagerie neurofonctionnelle (GIN), UMR 6194, CNRS/CEA/Université de Caen/Université Paris-V, centre Cyceron, boulevard H.-Becquerel, 14000Caen, France Centre Esquirol, centre hospitalier et universitaire de Caen, 14033Caen, France
*
*Corresponding author. E-mail address: france.dollfus-s@chu-caen.fr (S. Dollfus).
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Abstract

Fifty to eighty-five percent of schizophrenic patients are impaired on ocular pursuit paradigms. However, results regarding the relatives are more discordant. The aim of this study was to investigate whether eye movement disorders could be a vulnerability marker of schizophrenia.

Method

Twenty-one schizophrenic patients (DSM-IV), 31 first-degree relatives of those patients without schizophrenic spectrum disorders, and two groups of healthy controls matched by age and sex were included. Three oculomotor tasks (smooth pursuit, reflexive saccades and antisaccades) were used.

Results

Patients had a lower averaged gain (P = 0.035) during smooth pursuit than controls, made less correct visually guided saccades (P < 0.001) and more antisaccades errors (P = 0.002) than controls. In contrast, none of the comparison between the relatives and their controls was significant.

Conclusions

Schizophrenic patients were impaired on smooth pursuit and antisaccade paradigms. None of these impairments was, however, observed in their first-degree relatives. Our results suggest that the eye movement parameters tested could not be considered as vulnerability markers for schizophrenia.

Keywords

SchizophreniaRelativesSmooth pursuit eye movementsSaccadesAntisaccadesGeneticsAge effect
Type
Original article
Information
European Psychiatry , Volume 20 , Issue 4 , June 2005 , pp. 339 - 345
Copyright
Copyright © Elsevier SAS 2005

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