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Catechol-O-methyltransferase gene promoter methylation as a peripheral biomarker in male schizophrenia

Published online by Cambridge University Press:  23 March 2020

S. Gao ,
J. Cheng ,
G. Li ,
T. Sun ,
Y. Xu ,
Y. Wang ,
X. Du ,
G. Xu  and
S. Duan
S. Gao
Affiliation:
Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang315201, China
J. Cheng*
Affiliation:
Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang315201, China
G. Li
Affiliation:
Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang315201, China
T. Sun
Affiliation:
School of Medicine, Ningbo University, Ningbo, Zhejiang315211, China
Y. Xu
Affiliation:
Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang315201, China
Y. Wang
Affiliation:
Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang315201, China
X. Du
Affiliation:
Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang315201, China
G. Xu
Affiliation:
School of Medicine, Ningbo University, Ningbo, Zhejiang315211, China
S. Duan*
Affiliation:
School of Medicine, Ningbo University, Ningbo, Zhejiang315211, China
*
* Corresponding author. Tel.:/fax: +86 592 2292579.
* Corresponding author. Tel.:/fax: +86 592 2292579.
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Abstract

As an epigenetic modification, DNA methylation may reflect the interaction between genetic and environmental factors in the development of schizophrenia (SCZ). Catechol-O-methyltransferase (COMT) gene is a promising candidate gene of SCZ. In the present study, we investigate the association of COMT methylation with the risk of SCZ using bisulfite pyrosequencing technology. Significant association between DNA methylation of COMT and the risk of SCZ is identified (P = 1.618e−007). A breakdown analysis by gender shows that the significance is driven by males (P = 3.310e−009), but not by females. DNA methylation of COMT is not significantly associated with SCZ clinical phenotypes, including p300 and cysteine level. No interaction is found between COMT genotypes and the percent methylation of this gene. Receiver operating characteristic (ROC) curve shows that DNA methylation of COMT is able to predict the SCZ risk in males (area under curve [AUC] = 0.802, P = 1.91e−007). The current study indicates the clinical value of COMT methylation as a potential male-specific biomarker in SCZ diagnosis.

Keywords

COMTSchizophreniaEpigeneticDNA methylationBiomarkerMale
Type
Original article
Information
European Psychiatry , Volume 44 , July 2017 , pp. 39 - 46
Copyright
Copyright © European Psychiatric Association 2017

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Footnotes

1

SG, JC and GL are co-first authors of this work.

2

Present address: Zhongshan Hospital, Xiamen University, Xiamen, 361004, China.

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