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Corpus Callosum Size and Shape in Individuals with Bipolar Disorder and Their Relatives

Published online by Cambridge University Press:  16 April 2020

M. Walterfang ,
A. Wood ,
S. Barton ,
D. Velakoulis ,
J. Chen ,
C. Pantelis ,
D. Reutens ,
M. Kempton ,
M. Haldane  and
S. Frangou
M. Walterfang
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne
A. Wood
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne
S. Barton
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne
D. Velakoulis
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne
J. Chen
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, London, Australia
C. Pantelis
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne
D. Reutens
Affiliation:
Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne
M. Kempton
Affiliation:
Section of Neurobiology of Psychosis, Institute of Psychiatry, Kings College London
M. Haldane
Affiliation:
Section of Neurobiology of Psychosis, Institute of Psychiatry, Kings College London
S. Frangou
Affiliation:
Section of Neurobiology of Psychosis, Institue of Psychiatry, Kings College London, London, UK

Abstract

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Objective:

To examine genetic influences the anatomy of the Corpus Callosum (CC) in Bipolar Disorder (BD) by examining first-degree relatives in addition to BD patients.

Methods:

We compared CCl size and shape in 180 individuals: 70 with BD, 45 of their unaffected first-degree relatives, and 75 healthy controls. The CC was extracted from a mid-sagittal slice from T1-weighted magnetic resonance images; its total area, length and curvature were compared across groups. A non-parametric permutation method was used to examine for alterations in width of the callosum along 39 points.

Results:

Validating our previous findings, a significant global reduction in CC thickness was seen in BD patients, with a disproportionate thinning in the anterior body. First-degree relatives did not differ in CC size or shape from controls. Duration of illness was associated with thinning in the anterior body, whereas Lithium treatment associated with thicker anterior CC midbody.

Conclusions:

Global and regional CC thinning is a disease related feature of BD and may not represent a marker of familial disposition.

Type
P02-227
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E917
Copyright
Copyright © European Psychiatric Association 2009
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