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LAI versus oral: A case-control study on subjective experience of antipsychotic maintenance treatment

Published online by Cambridge University Press:  23 March 2020

F. Pietrini ,
M. Spadafora ,
L. Tatini ,
G.A. Talamba ,
C. Andrisano ,
G. Boncompagni ,
M. Manetti ,
V. Ricca  and
A. Ballerini
F. Pietrini*
Affiliation:
Psychiatric unit, department of neuroscience, psychology, drug research and child health, section of neuroscience, university of Florence, Via delle Gore 2HFlorence50134, Italy
M. Spadafora
Affiliation:
Psychiatric unit, department of neuroscience, psychology, drug research and child health, section of neuroscience, university of Florence, Via delle Gore 2HFlorence50134, Italy
L. Tatini
Affiliation:
Psychiatric unit, department of neuroscience, psychology, drug research and child health, section of neuroscience, university of Florence, Via delle Gore 2HFlorence50134, Italy
G.A. Talamba
Affiliation:
Psychiatric unit, department of neuroscience, psychology, drug research and child health, section of neuroscience, university of Florence, Via delle Gore 2HFlorence50134, Italy
C. Andrisano
Affiliation:
Department of biomedical and neuromotor sciences, university of Bologna, Bologna, Italy
G. Boncompagni
Affiliation:
Department of mental health and substance abuse, local health trust of Bologna, Bologna, Italy
M. Manetti
Affiliation:
Therapeutic psychiatric community, Campo del Vescovo Union, La Spezia, Italy
V. Ricca
Affiliation:
Psychiatric unit, department of neuroscience, psychology, drug research and child health, section of neuroscience, university of Florence, Via delle Gore 2HFlorence50134, Italy
A. Ballerini
Affiliation:
Psychiatric unit, department of neuroscience, psychology, drug research and child health, section of neuroscience, university of Florence, Via delle Gore 2HFlorence50134, Italy
*
* Corresponding author. Tel.: +39 055 794 7487; fax: +39 055 794 7531. E-mail address:francesco.pietrini@unifi.it (F. Pietrini).
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Abstract

Background

To present real-world evidence on the differences between long-acting injectable (LAI) and oral antipsychotic maintenance treatment (AMT) in terms of subjective well-being, attitudes towards drug and quality of life in a sample of remitted schizophrenic subjects.

Methods

Twenty outpatients with remitted schizophrenia treated with either olanzapine or paliperidone and switching from the oral to the LAI formulation of their maintenance treatment were recruited before the switch (LAI-AMT group). A group of 20 remitted schizophrenic subjects with oral AMT and matching main sociodemographic, clinical and treatment variables made up the control group (oral-AMT group). All participants were assessed in terms of objective (PANSS, YMRS, MADRS) and subjective (SWN-K, DAI-10, SF-36) treatment outcomes at baseline (T0) and after 6 months (T1).

Results

Between T0 and T1, general psychopathology of the PANSS, DAI-10, and all but one of the SWN-K dimensions (except for social integration), showed significantly higher percentages of improvement in the LAI-AMT group compared to the oral-AMT group. A generalized expansion of health-related quality of life, with better functioning in almost all areas of daily living, was reported by the LAI-AMT group after the 6-month period. In contrast, the oral-AMT group reported a significant worsening of health-related quality of life in the areas of emotional role and social functioning in the same period.

Conclusions

Our study indicates possible advantages of LAI over oral antipsychotic formulation in terms of subjective experience of maintenance treatment in remitted schizophrenic patients. Size and duration of this study need to be expanded in order to produce more solid and generalizable results.

Keywords

Schizophrenia and psychosisAntipsychoticsQuality of lifeQuality of care
Type
Original article
Information
European Psychiatry , Volume 37 , September 2016 , pp. 35 - 42
Copyright
Copyright © European Psychiatric Association 2016

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