Hostname: page-component-848d4c4894-ttngx Total loading time: 0 Render date: 2024-05-17T12:41:50.848Z Has data issue: false hasContentIssue false
  • English
  • Français

Methodological considerations and empirical data to the onset of efficacy of antidepressants and to the prediction of therapy outcome

Published online by Cambridge University Press:  16 April 2020

H Müller  and
H.J. Möller
H Müller
Affiliation:
Psychiatric Department of the University of Bonn, Sigmund-Freud-Str 25, D-53105Bonn
H.J. Möller
Affiliation:
Psychiatric Department of the Ludwig-Maximilians-University of Munich, Germany
Get access

Summary

Is the onset of efficacy of antidepressants always delayed and which early clinical signs predict final outcome of therapy ? Our analyses show that strict response criteria produce necessarily later onset estimations rather than less strict ones. In two large-scale clinical samples we compared different estimation methods of the day of onset. Patients' direct ratings produced the earliest onset estimations. Because of the strong dependency of onset estimations on measurement methods, we argue that it is still open to debate, in which degree drug response is delayed. Concerning early clinical signs of final outcome we compared early changes of the Hamilton Rating Scale for Depression (HAM-D) items with several measures of final outcome. From the data we analyzed, there are no sufficiently precise signs of final outcome within the first 2 weeks of therapy.

Keywords

depressionantidepressantsonset of efficacymethods
Type
Research Article
Information
European Psychiatry , Volume 12 , Issue 4 , 1997 , pp. 177 - 182
Copyright
Copyright © Elsevier, Paris 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Hamilton, MA rating scale for depression J Neurol Neurosurg Psychiatry 23 1960 56–62CrossRefGoogle ScholarPubMed
Möller, H.J.Volz, HPBrofaromine in major depressed patients: a controlled clinical trial versus imipramine and open follow-up of up to one year J Affective Dis 26 1992 163–172CrossRefGoogle ScholarPubMed
Möller, H.J.Volz, HPBrofaromine in elderly major depressed patients — a comparative trial versus imipramine Eur Neuropsychopharmacol 3 1993 501–510CrossRefGoogle ScholarPubMed
Möller, H.J.Müller, HVolz, HPHow to assess the onset of anti-depressant effect: comparison of global ratings and findings based on depression scales Pharmacopsychiatry 29 1996 57–62CrossRefGoogle Scholar
Möller, H.J.Kasper, SMüller, Het al. A controlled study of the efficacy and safety of mianserin and amitriptyline in depressive inpatients Pharmacopsychiatry 28 1995 249–252CrossRefGoogle ScholarPubMed
National Institute of Mental Health 12-CGI. Clinical global impressionsIn: Guy, WBonato, RR eds. Manual for the ECDEU Assessment Battery 2nd rev edn Chevy Chase 12 1970 1–6Google Scholar
Quitkin, FMRabkin, JGRoss, DStewart, JWIdentification of true drug response to antidepressants Arch Gen Psychiatry 41 1984 782–786CrossRefGoogle Scholar
Quitkin, FMRabkin, JGMarkowitz, JMet alUse of pattern analysis to identify true drug response. Arch Gen Psychiatry 44 1987 259–264CrossRefGoogle ScholarPubMed
Stassen, HHDelini-Stula, AAngst, JTime course of improvement under antidepressant treatment: a survival-analytical approach Eur Neuropsychopharmacol 3 1993 127–135CrossRefGoogle ScholarPubMed
Volz, HPMüller, HSturm, YMöller, H.J.Initial antidepressant drug treatment effect as a predictor for outcome after 8 weeks Psychiatry Res 58 1995 107–115CrossRefGoogle ScholarPubMed
Zerssen von, D (unter Mitarbeit von D. Köller). Klinische Selbstbeurteilungsskalen (KSb-S) aus dem Münchener Psychiatrischen Informationssystem (Psychis München), Manuale 1976 Beltz Weinheim70Google Scholar
Submit a response

Comments

No Comments have been published for this article.