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Neuroendocrine and immunological functions in depressed patients: a follow-up study

Published online by Cambridge University Press:  16 April 2020

S Cervera-Enguix  and
A Rodríguez-Rosado
S Cervera-Enguix
Affiliation:
University of Navarra and Psychiatry and Medical Psychology Department, Universitary Hospital of the University of Navarra
A Rodríguez-Rosado
Affiliation:
Universitary Hospital of the University of Navarra, Pamplona, (Navarra) Spain
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Summary

The development, evaluation and use of biological markers with a diagnostic purpose in psychiatry is extremely important. However, with certain exceptions, truly sensitive and specific markers have not yet emerged. In order to investigate the relationship between the immune apparatus and the hypothalamic-pituitary activity on the one hand, and the psychopathological state of the patients on the other, we used a longitudinal design and assessed monocyte parameters (HLA-DR, CD 35, vimentin filaments, and phagocytosis index) and neuroendocrine tests (dexamethasone suppression test [DST] and thyrotropin-releasing hormone [TRH] stimulation test) at intake and at follow-up in 49 depressed patients. Immunological parameters were compared with neuroendocrine tests in both phases of the study. The combined use of both immunological and neuroendocrine tests did not add sensitivity to the immunological identification of depressed patients. The findings lead us to consider the role of the monocyte parameters as sensitive depressive state markers, while the combined use of both neuroendocrine and immunological tests in current clinical practice would be debatable.

Keywords

depressionDSTTRH testmonocyte dysfunction
Type
Original Articles
Information
European Psychiatry , Volume 10 , Issue 1 , 1995 , pp. 49 - 55
Copyright
Copyright © Elsevier, Paris 1995

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Footnotes

This investigation has been made possible by a grant from the Areces Foundation, Spain.

References

Albrecht, JHelderman, JHSchlesser, MARush, AJA controlled study of cellular immune function in affective disorders before and during somatic therapy. Psychiatry Res. 1985;15: 185–93CrossRefGoogle ScholarPubMed
Auger, MJRoss, JAThe biology of the macrophage. In: Lewis, CEMcGee, JThe macrophage. New York: Oxford University Press, 1992 3–74Google Scholar
Berkenbosch, FHeijnen, CJCroiset, GRevers, CBallieux, REBinnekade, RTilders, FJHEndocrine and immunological responses to acute stress. In: Plotnikoff, NPFaith, REMurgo, AJGood, RAEnkephalins and Endorphins: Stress and the Immune System. New York: Plenum Press, 1986 109–1810.1007/978-1-4899-0557-4_10CrossRefGoogle Scholar
Bianco, CPatrick, RNussenzwig, VA population of lymphocytes bearing membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J Exp Med. 1970;132: 702–20CrossRefGoogle ScholarPubMed
Blalock, JESmith, EMHuman leukocyte interferon: structural and biological relatedness to adrenocorticotrophic hormones and endorphins. Proc Natl Acad Sci USA. 1980;77: 5975–810.1073/pnas.77.10.5972CrossRefGoogle Scholar
Blalock, JEHarp, CInterferon and adrenocorticotropic hormone induction of steroidogenesis, melanogenesis and antiviral activity. Arch Virol. 1981;67: 45–910.1007/BF01314600CrossRefGoogle ScholarPubMed
Bormann, BJHuang, CKLan, GFJaffe, EAThrombin-induced vimentin phosphorylation in cultured human umbilical vein endothelial cells. J Biol Chem. 1986;261: 10471–4Google ScholarPubMed
Boyum, AIsolation of human blood monocytes with Nycodenz, a new non-ionic iodinated gradient medium. Scand J Immunol. 1983;17: 429–3610.1111/j.1365-3083.1983.tb00809.xCrossRefGoogle ScholarPubMed
Browning, ETSanders, MMVimentin: a phosphoprotein under hormonal regulation. J Cell Biol. 1981;90: 803–810.1083/jcb.90.3.803CrossRefGoogle ScholarPubMed
Catala, JBenzodiazepin Effects on Mononuclear-Macrophage System.Doctoral Thesis. University of Navarra, Pamplona, 1992Google Scholar
Chang, KGOpioid peptides have actions on the immune system. Trends Neurosci. 1984;7: 234–510.1016/S0166-2236(84)80212-XCrossRefGoogle Scholar
Cervera, SSarrais, FRamos, FDepression, Immune System and Neuroendocrine Tests.Spanish Biological Psychiatry Association, 15th National Meeting. Cordoba, Spain 1990Google Scholar
Cervera, SRosado, ARDepression and Monocyte Function: A Follow-up Study. 1993(in press)Google Scholar
Cohen, MRPickar, DDubois, MCohen, RMStudies of the endogenous opioid system in the human stress response. In: Plotnikoff, NPFaith, REMurgo, AJGood, RAEnkephalins and Endorphins: Stress and the Immune System. New York: Plenum Press, 1986 35–46CrossRefGoogle Scholar
Darko, DFGillin, JCRisch, SC et al. Immune cells and hypothalamic-pituitary axis in major depression. Psychiatry Res. 1988;25: 173–9CrossRefGoogle ScholarPubMed
Darko, DFGillin, JCRisch, SC et al. Mitogen-stimulated lymphocyte proliferation and pituitary hormones in major depression. Biol Psychiatry. 1989;26: 145–55CrossRefGoogle ScholarPubMed
Frochner, SCThe role of the postsinaptic cytoskeleton in AchR organization. Trends Neurosci. 1986;9: 37–8CrossRefGoogle Scholar
Geiger, BIntermediate filaments. Looking for a function. Nature. 1987;329: 392–310.1038/329392a0CrossRefGoogle ScholarPubMed
Giorgi, JVLymphocyte subset measurements: significance in clinical medicine. In: Rose, NRFriedman, HFancy, JLManual of Clinical Immunology. Washington, DC: American Society for Microbiology, 1986 236–46Google Scholar
Glassman, AThe dexamethasone suppression test: an overview of its current status in psychiatry. Am J Psychiatry. 1987;144: 1253–62Google Scholar
Hamilton, MA rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23: 56–6110.1136/jnnp.23.1.56CrossRefGoogle ScholarPubMed
Irwin, MLacher, UCaldwell, CDepression and reduced natural killer cytotoxicity: a longitudinal study of depressed patients and control subjects. Psychol Med. 1992;22: 1045–5010.1017/S0033291700038617CrossRefGoogle ScholarPubMed
Kronfol, ZHouse, DJSilva, JRGreden, JCarrol, BJDepression, urinary free cortisol excretion and lymphocyte function. Br J Psychiatry. 1986;148: 70–310.1192/bjp.148.1.70CrossRefGoogle ScholarPubMed
Krishnan, REllinwood, EHLaszlo, JHood, LRitchie, JEffect of gamma interferon on the hypothalamic-pituitary-adrenal system. Biol Psychiatry. 1987;22: 1163–610.1016/0006-3223(87)90059-XCrossRefGoogle ScholarPubMed
Lazarides, EIntermediate filaments as mechanical integrators of cellular space. Nature. 1980;283: 249–56CrossRefGoogle ScholarPubMed
Lopker, AAbood, LGHoss, WLionetti, FGSteroselective muscarinic acetylcholine and opiate receptors in human phagocytic leukocytes. Biochem Pharmacol. 1980;29: 1361–510.1016/0006-2952(80)90431-1CrossRefGoogle Scholar
Maes, MVandervorst, CSuy, EMinner, BRaus, JA multivariate study on the simultaneous free cortisol, adrenocorticotropic hormone and beta-endorphin escape from suppression by dexamethasone in depressed patients. Acta Psychiatr Scand. 1990;83: 480–91CrossRefGoogle Scholar
Maes, MBosmans, ESuy, EMinner, BRaus, JA further exploration of the relationships between immune parameters and the HPA-axis activity in depressed patients. Psychol Med. 1991;21: 313–20CrossRefGoogle ScholarPubMed
Maes, MLambrechts, JBosmans, EJacobs, JSuy, EVandervorst, CDe Jonckheere, CMinner, BRaus, JEvidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining. Psychol Med. 1992;22: 45–5310.1017/S0033291700032712CrossRefGoogle ScholarPubMed
Pert, CBRuff, MRWeber, RTHerkenham, MNeuropeptides and their receptors: a psychosomatic network. J Immunol. 1985;135: 820–6Google ScholarPubMed
Plotnikoff, NPMiller, GCEnkephalins as immunomodulators. Intern J Immunopharmacol. 1983;5: 437–41CrossRefGoogle ScholarPubMed
Plotnikoff, NPMurgo, AJMiller, GCCorder, CNFaith, REEnkephalins: immunomodulators. Fred Proc. 1985;44: 118–22Google ScholarPubMed
Plotnikoff, NPFaith, REMurgo, AJGood, RAIntroduction: the ying-yang hypothesis of immunomodulation. In: Plotnikoff, NPFaith, REMurgo, AJGood, RAEnkephalins and Endorphins: Stress and the Immune System. New York: Plenum Press, 1986 1–2CrossRefGoogle Scholar
Prieto, JSubira, MLCastilla, ASerrano, MNaloxone-reversible monocyte dysfunction in patients with chronic fatigue syndrome. Scand J Immunol. 1989;30: 13–20CrossRefGoogle ScholarPubMed
Prieto, JCamps-Bansell, JCastilla, AOpioid-mediated monocyte dysfunction in the chronic fatigue syndrome. In: Bonnie, CameronThe Clinical and Scientific Basis of Mialgic Encephalomielitis/Chronic Fatigue Syndrome. Ottawa, Ontario (Canada) and Ogsdenburg, New York State (USA) 1992 575–584Google Scholar
Recalde, HRA simple method of obtaining monocytes in suspension. J Immunol Methods. 1984;69: 71–710.1016/0022-1759(84)90278-3CrossRefGoogle ScholarPubMed
Rubin, RTPharmacoendocrinology of major depression. Eur Arch Psychiatr Neurol Sci. 1989;238: 259–6710.1007/BF00449807CrossRefGoogle ScholarPubMed
Ruff, MRPert, CBHuman monocyte chemotaxis to neuropeptides. In: Nerozzi, DGoodwin, FKCosta, EHypothalamic Dysfunction in Neuropsychiatric Disorders. New York: Raven Press, 1987 247–60Google Scholar
Shavit, YTerman, GWMartin, FCLewis, JWLiebeskind, JCGale, RPStress, opioid peptides, the immune system, and cancer. J Immunol. 1985;135: 834–7Google ScholarPubMed
Smith, EMBlalock, JEA complete regulatory loop between the immune and neuroendocrine systems operates through common signal molecules (hormones) and receptors. In: Plotnikoff, NPFaith, REMurgo, AJGood, RAEnkephalins and Endorphins: Stress and the Immune System. New York: Plenum Press, 1993 119–128Google Scholar
Solomon, GSKay, NMorley, JEEndorphins: a link between personality, stress, emotions, immunity, and disease?. In: Plotnikoff, NPFaith, REMurgo, AJGood, RAEnkephalins and Endorphins: Stress and the Immune System. New York: Plenum Press, 1986 129–44CrossRefGoogle Scholar
Spitzer, RLEndicott, JRobin, EResearch Diagnostic Criteria: rationale and reliability. Arch Gen Psychiatry. 1978;35: 773–82CrossRefGoogle ScholarPubMed
Thalen, BEKjellman, BFLjunggren, JGAkner, GKagedal, BWahlund, BWetterberg, LRelease of corticotropin after administration of corticotropin-releasing hormone in depressed patients in relation to the dexamethasone suppression test. Acta Psychiatr Scand. 1993;87: 133–40CrossRefGoogle ScholarPubMed
Tsoko, GCBalow, JERegulation of human cellular immune responses by glucocorticosteroids. In: Plotnikoff, NPFaith, REMurgo, AJGood, RAEnkephalins and Endorphins: Stress and the Immune System. New York: Plenum Press, 1986 159–72CrossRefGoogle Scholar
Vallejo, JGasto, CCatalán, RBulvena, AMenchon, JMPredictors of antidepressant treatment outcome in melancholia: psychosocial, clinical and biological indicators. J Affective Discord. 1992;21: 151–6210.1016/0165-0327(91)90036-RCrossRefGoogle Scholar
Williams, JBSpitzer, RLResearch Diagnostic Criteria and DSM-III: an annotated comparison. Arch Gen Psychiatry. 1982;39: 1283–910.1001/archpsyc.1982.04290110039007CrossRefGoogle ScholarPubMed
Wybran, JAppelbloom, TFamely, JFGovaerts, ASuggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes. J Immunol. 1979;123: 1068–70Google ScholarPubMed
Wybran, JEnkephalins and endorphins as modifiers of the immune system: present and future. Fed Proc. 1985;44: 92–4Google ScholarPubMed
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