The aim of our work was to find out about the efficiency of Trazodon in treating depressive disorder with alcoholics who were patients at the department for alcohol addiction at the Psychiatric Hospital G. Toponica (15 patients). For completing this research we used Beck's scale to evaluate the degree of depression. The research lasted for 6 weeks. Alredy after the first week of consuming there was a progress concerning sleeping and reduction of anxiety. The anti-depressing score was evident already after two weeks, there also has been a remarkable dropping of the amount on Beck's scale for evaluation of depression. Throughout the research of the efficiency with depression symptomatology the dayly dosage for alcoholics wasn’t over the amount of 150mg. A clinical study in the duration of 6 weeks showed that Trazodon successfully reduced the symptoms of depression with alcohol addicts and that it after hospitalized treatment helped to maintain in conditions after leaving the institution. It was equaly used on young and elderly patients without any negative effects.