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Platelet monoamine oxidase in attempted suicide. Relations to sex, psychiatric diagnosis, mode of attempt, and previous attempts

Published online by Cambridge University Press:  16 April 2020

J Tripodianakis ,
M Markianos ,
D Sarantidis ,
C Istikoglou ,
A Andara  and
E Bistolaki
J Tripodianakis
Affiliation:
Psychiatric Department, Evangelismos General Hospital Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Athens, Greece
M Markianos
Affiliation:
Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Athens, Greece
D Sarantidis
Affiliation:
Psychiatric Department, Evangelismos General Hospital Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Athens, Greece
C Istikoglou
Affiliation:
Psychiatric Department, Evangelismos General Hospital Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Athens, Greece
A Andara
Affiliation:
Psychiatric Department, Evangelismos General Hospital Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Athens, Greece
E Bistolaki
Affiliation:
Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Athens, Greece
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Summary

Platelet monoamine oxidase (MAO) activities were assessed in 82 patients, 57 females and 25 males, who were admitted to the medical ward of a general hospital after a suicide attempt. The enzyme activities were compared to the activities of healthy subjects, 35 females and 26 males. In addition, MAO activities were analyzed in relation to sex, psychiatric diagnosis, mode of attempt, drugs ingested, and previous attempts. Compared to normal controls, only female patients showed lower MAO activities. In the male population, lower activities were found in the subgroup of patients who had made previous attempts. In relation to diagnosis, analysis performed in the female population revealed lower MAO activities in the dysthymic and personality disorder, and not in the adjustment or major affective disorder subgroups. MAO activities were not related to the violent mode of attempt, the type of medication used, or the score in the Beck Suicidal Intent scale. The finding of low platelet MAO activities in dysthymic disorder, indicates the need for further studies of biological variables in this underdiagnosed and undertreated diagnostic group.

Keywords

attempted suicideplatelet MAOpsychiatric diagnosisdysthymic disorderpersonality disorder
Type
Original Articles
Information
European Psychiatry , Volume 10 , Issue 1 , 1995 , pp. 44 - 48
Copyright
Copyright © Elsevier, Paris 1995

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