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A review of the safety of paroxetine

Published online by Cambridge University Press:  16 April 2020

SA Montgomery
SA Montgomery*
Affiliation:
Academic Department of Psychiatry, St Mary's Hospital, London, UK
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Summary

The tolerability and safety of treatment with paroxetine have been assessed by analysis of a clinical trial database that extends to 4126 patients treated with paroxetine, 1954 patients on active control, and 625 placebo patients. A total of 451 patients were exposed to paroxetine for periods of 1 or more years. Paroxetine was generally better tolerated than active control and was associated with a lower frequency of manic reactions in bipolar patients and fewer seizures than active control. Paroxetine appears to offer a differential advantage in reducing suicidal thoughts; the number of suicides and attempted suicides per patient exposure year were lower for paroxetine than for other antidepressants or placebo.

Keywords

paroxetinesafetytolerabilitysuicidality
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S1: New perspectives in the pharmacological treatment of depression. Defining the ideal antidepressant. 3 November 1992, Barcelona, Spain , 1993 , pp. 25s - 30s
Copyright
Copyright © Elsevier, Paris 1993

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