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Schizophrenia, antipsychotics and diabetes: Genetic aspects

Published online by Cambridge University Press:  16 April 2020

F. Bellivier
F. Bellivier*
Affiliation:
Department of Psychiatry, CHU Henri-Mondor, 94010Créteil cedex, France Inserm U513, faculté de médecine, 94010Creted cedex, France
*
E-mail address: bellivier@im3.inserm.fr (F. Bellivier).
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Abstract

The relatively high comorbidity of type 2 diabetes and schizophrenia may suggest a shared biological susceptibility to these twoconditions. Family studies have demonstrated an increased risk of diabetes in unaffected relatives of patients with schizophrenia, consistent with a heritable susceptibility trait. Linkage analyses have identified several loci that are associated with schizophrenia and some of these, notably those on chromosomes 2p22.1-p13.2 and 6g21-824.1 have also been observed in linkage studies in type 2 diabetes. In addition, the dopamine D5 receptor on chromosome 5 and the tyrosine hydroxylase gene on chromosome 11 have both been suggested as candidate genes in schizophrenia and may also be implicated in susceptibility to poor glycaemic control. In addition, an increased rate of type II diabetes has been observed in some patients treated with antipsychotics. Potential neurochemical substrates of this effect include the histamine H1 receptor, the 5-HT2C serotonin receptor or the β3 adrenoreceptor. However, the search for a genetic basis to the association between diabetes and schizophrenia is still in its infancy, and much further work needs to be performed, including the systematic screening of all confirmed susceptibility loci and quantitative trait locus mapping of glycaemic control.

Keywords

SchizophreniaAntipsychoticsDiabetes
Type
Research Article
Information
European Psychiatry , Volume 20 , Issue S4 , December 2005 , pp. S335 - S339
Copyright
Copyright © European Psychiatric Association 2005

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