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Serotonergic response to stress: A protective factor against abnormal dopaminergic reactivity in schizophrenia?

Published online by Cambridge University Press:  06 April 2007

Jerome Brunelin ,
Thierry D'amato ,
Jim van Os ,
Jean Dalery ,
Marie-Françoise Suaud-Chagny  and
Mohamed Saoud
Jerome Brunelin*
Affiliation:
Université de Lyon, Lyon, F-69003, France Université Lyon 1, EA3092, CH le Vinatier, 95 boulevard Pinel, F-69 677 Bron cedex, France Institut Fédératif des Neurosciences de Lyon, IFNL, Lyon, France Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO BOX 616 (DRT 10), 6200MD Maastricht, The Netherlands
Thierry D'amato
Affiliation:
Université de Lyon, Lyon, F-69003, France Université Lyon 1, EA3092, CH le Vinatier, 95 boulevard Pinel, F-69 677 Bron cedex, France Institut Fédératif des Neurosciences de Lyon, IFNL, Lyon, France
Jim van Os
Affiliation:
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO BOX 616 (DRT 10), 6200MD Maastricht, The Netherlands Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Jean Dalery
Affiliation:
Université de Lyon, Lyon, F-69003, France Université Lyon 1, EA3092, CH le Vinatier, 95 boulevard Pinel, F-69 677 Bron cedex, France Institut Fédératif des Neurosciences de Lyon, IFNL, Lyon, France
Marie-Françoise Suaud-Chagny
Affiliation:
Université de Lyon, Lyon, F-69003, France Université Lyon 1, EA3092, CH le Vinatier, 95 boulevard Pinel, F-69 677 Bron cedex, France Institut Fédératif des Neurosciences de Lyon, IFNL, Lyon, France
Mohamed Saoud
Affiliation:
Université de Lyon, Lyon, F-69003, France Université Lyon 1, EA3092, CH le Vinatier, 95 boulevard Pinel, F-69 677 Bron cedex, France Institut Fédératif des Neurosciences de Lyon, IFNL, Lyon, France
*
∗Corresponding author. EA 3092, Service du Pr Dalery, CH le vinatier, 95 bd Pinel 69677 Bron cedex France. Tel.: +33 437915565; fax: +33 437915549. E-mail address: jerome.brunelin@ch-le-vinatier.fr (J. Brunelin).
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Abstract

In a double-blind-crossover-study, 10 patients with schizophrenia, 10 of their unaffected siblings and 9 healthy controls randomly received metabolic stressor and placebo. A significant HVA plasma elevation in response to stress was found in siblings whose response was intermediate to that of patients and controls. Only siblings additionally displayed an exaggerated 5HIAA response.

Keywords

SchizophreniaVulnerability–stress modelPrevention
Type
Short communication
Information
European Psychiatry , Volume 22 , Issue 6 , September 2007 , pp. 362 - 364
Copyright
Copyright © Elsevier Masson SAS 2007

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