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Tianeptine: clinical properties

Published online by Cambridge University Press:  16 April 2020

H Lôo ,
B Delalleau  and
A Kamoun
H Lôo
Affiliation:
SHU de Santé Mentale el de Thérapeutique, Hôpital Sainte-Anne, I, rue Cabanis, 75014Paris
B Delalleau
Affiliation:
IRIS, 6, place des Pléiades, 92415Courbevoie Cedex, France
A Kamoun
Affiliation:
IRIS, 6, place des Pléiades, 92415Courbevoie Cedex, France
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Summary

Tianeptine has been shown to be an effective antidepressant versus reference drugs and to be better tolerated than amitriptyline, without the latter's anticholinergic side-effects. Its good acceptability has been confirmed in long-term use (1 year) in large patient groups. In an open pilot trial in endogenous melancholia, tianeptine showed the same activity as would be expected of a conventional antidepressant. This is being verified in a double-blind trial versus maprotiline. In a separate open study, it has demonstrated a potential to prevent relapse and recurrence in depressed patients treated for 1 year. These results are currently being tested versus placebo.

Keywords

depressionrelapserecurrencetianeptine
Type
Research Article
Information
European Psychiatry , Volume 8 , Issue S2: Neuroendocrinological aspects of depression 28 June 1992, Nice, France , 1993 , pp. 103s - 109s
Copyright
Copyright © Elsevier, Paris 1993

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