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Uric acidas a predictor of bipolar disorder type 1

Published online by Cambridge University Press:  13 August 2021

Ö. Baş Uluyol  and
Ö. Şahmelikoğlu Onur
Ö. Baş Uluyol
Affiliation:
Psychiatry, Sancaktepe Şehit Prof. Dr. İlhan Varank Research & Training Hospital, İstanbul, Turkey
Ö. Şahmelikoğlu Onur*
Affiliation:
Psychiatry, Bakirkoy Research & Training Hospital for Psychiatry, Neurology and Neurosurgery, İstanbul, Turkey
*
*Corresponding author.

Abstract

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Introduction

It has been shown in the studies that purinergic system dysfunction might have an effect on pathophysiology of bipolar disorder.

Objectives

In this study, our aims were to compare uric acid levels between patient with bipolar disorder type 1 (BPD1) and healthy controls (HC) and to evaluate the validity of uric acid in predicting bipolar disorder.

Methods

Consecutive outpatients with a diagnosis of euthymic BPD-1 (n=75) and HC (n=75) were included in the study. The subjects were evaluated with Sociodemographic Data Form, Young Mani Rating Scale (YMRS), Beck Depression Scale. Serum uric acid was measured using an auto analyzer.

Results

Serum uric acid level in BPD1 group was significantly higher than HC. Significant efficacy of uric acid value was observed in the differentiation of BPD1 and HC [Area under the curve 0.708(0.626-0.790)]. Significant efficacy of uric acid 5.4 cut off value was observed in the differentiation of BPD1 and HC [Area under the curve 0.667 (0.579-0.8754)]. Sensitivity was 50.7%, positive predictive value (PPV) was 74.5%, specificity was 82.7%, negative predictive value (NPV) was 62.6%.

Conclusions

Serum uric acid value is effective in detecting bipolar patients.

Disclosure

No significant relationships.

Keywords

uric acidpurinergic system dysfunctionbipolar disorder
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S626
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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