The feasibility of commencing tapping (‘opening’) of rubber trees for latex extraction at a lower stem girth (40 and 45 cm) than the currently recommended 50 cm was investigated in three different genotypes. The possibility of combining early opening with low frequency tapping and yield stimulation using Ethrel (LFT + E) was also examined. One of the genotypes tested, RRIC 121, gave a higher dry rubber yield, both per tapping and cumulatively over a given period, when opened at 40 cm than at 50 cm. Of the other two genotypes, one (RRISL 211) showed a clear reduction in yield with early opening, while the other (RRIC 102) did not show a significant yield response. Among the three genotypes tested, RRIC 121 showed the minimum depression in trunk girth increment. Analysis of yield components showed that the response of a given genotype to early opening and LFT + E is determined by the interaction between latex volume per tapping and dry rubber content (DRC), which were negatively correlated. RRIC 121 had a significantly greater DRC, which enabled it to maintain a higher dry rubber yield under early opening and LFT + E despite producing a lower latex volume than both the other genotypes. In contrast, despite producing a substantially greater latex volume than the other two genotypes, RRISL 211 did not produce a higher dry rubber yield because of its lower DRC. The higher DRC was also responsible for the greater response of RRIC 121 to yield stimulation with Ethrel, which reduced the plugging index and increased the initial latex flow rate. Early commencement of tapping in combination with LFT + E is therefore possible in rubber when amenable genotypes are selected, offering the potential of improving the economics of rubber production, especially for smallholders, in West Asia.