Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 63
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Di Scala, Coralie Yahi, Nouara Boutemeur, Sonia Flores, Alessandra Rodriguez, Léa Chahinian, Henri and Fantini, Jacques 2016. Common molecular mechanism of amyloid pore formation by Alzheimer’s β-amyloid peptide and α-synuclein. Scientific Reports, Vol. 6, p. 28781.


    Fantini, Jacques Di Scala, Coralie Baier, Carlos J. and Barrantes, Francisco J. 2016. Molecular mechanisms of protein-cholesterol interactions in plasma membranes: Functional distinction between topological (tilted) and consensus (CARC/CRAC) domains. Chemistry and Physics of Lipids,


    Mandal, Pritam Noutsi, Pakiza and Chaieb, Sahraoui 2016. Cholesterol Depletion from a Ceramide/Cholesterol Mixed Monolayer: A Brewster Angle Microscope Study. Scientific Reports, Vol. 6, p. 26907.


    Richichi, Barbara Pastori, Claudia Gherardi, Stefano Venuti, Assunta Cerreto, Antonella Sanvito, Francesca Toma, Lucio Lopalco, Lucia and Nativi, Cristina 2016. GM-3 Lactone Mimetic Interacts with CD4 and HIV-1 Env Proteins, Hampering HIV-1 Infection without Inducing a Histopathological Alteration. ACS Infectious Diseases,


    Aiamkitsumrit, Benjamas Sullivan, Neil T. Nonnemacher, Michael R. Pirrone, Vanessa and Wigdahl, Brian 2015.


    Andrianov, Alexander M. Kornoushenko, Yuri V. Kashyn, Ivan A. Kisel, Mikhail A. and Tuzikov, Alexander V. 2015. In silico design of novel broad anti-HIV-1 agents based on glycosphingolipid β-galactosylceramide, a high-affinity receptor for the envelope gp120 V3 loop. Journal of Biomolecular Structure and Dynamics, Vol. 33, Issue. 5, p. 1051.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Fantini, Jacques and Yahi, Nouara 2015. Brain Lipids in Synaptic Function and Neurological Disease.


    Ho, Philip Wing-Lok Pang, Shirley Yin-Yu Li, Miaoxin Tse, Zero Ho-Man Kung, Michelle Hiu-Wai Sham, Pak-Chung and Ho, Shu-Leong 2015. PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion. Brain and Behavior, Vol. 5, Issue. 4, p. n/a.


    ×

Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases

  • Jacques Fantini (a1), Nicolas Garmy (a1), Radhia Mahfoud (a1) and Nouara Yahi (a1)
  • DOI: http://dx.doi.org/10.1017/S1462399402005392
  • Published online: 20 December 2002
Abstract

The fluid mosaic model of the plasma membrane has evolved considerably since its original formulation 30 years ago. Membrane lipids do not form a homogeneous phase consisting of glycerophospholipids (GPLs) and cholesterol, but a mosaic of domains with unique biochemical compositions. Among these domains, those containing sphingolipids and cholesterol, referred to as membrane or lipid rafts, have received much attention in the past few years. Lipid rafts have unique physicochemical properties that direct their organisation into liquid-ordered phases floating in a liquid-crystalline ocean of GPLs. These domains are resistant to detergent solubilisation at 4°C and are destabilised by cholesterol- and sphingolipid-depleting agents. Lipid rafts have been morphologically characterised as small membrane patches that are tens of nanometres in diameter. Cellular and/or exogenous proteins that interact with lipid rafts can use them as transport shuttles on the cell surface. Thus, rafts act as molecular sorting machines capable of co-ordinating the spatiotemporal organisation of signal transduction pathways within selected areas (‘signalosomes’) of the plasma membrane. In addition, rafts serve as a portal of entry for various pathogens and toxins, such as human immunodeficiency virus 1 (HIV-1). In the case of HIV-1, raft microdomains mediate the lateral assemblies and the conformational changes required for fusion of HIV-1 with the host cell. Lipid rafts are also preferential sites of formation for pathological forms of the prion protein (PrPSc) and of the β-amyloid peptide associated with Alzheimer's disease. The possibility of modulating raft homeostasis, using statins and synthetic sphingolipid analogues, offers new approaches for therapeutic interventions in raft-associated diseases.

Copyright
Corresponding author
Laboratoire de Biochimie et Physicochimie des Membranes Biologiques, Institut Méditerranéen de Recherche en Nutrition, UMR-INRA 1111, Faculté des Sciences de St-Jérôme, 13331 Marseille cedex 20, France. Tel: +33 491 288 761; Fax: +33 491 288 440; E-mail: jacques.fantini@univ.u-3mrs.fr
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Expert Reviews in Molecular Medicine
  • ISSN: -
  • EISSN: 1462-3994
  • URL: /core/journals/expert-reviews-in-molecular-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: