Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 29
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Le Guellec, Sophie Decouvelaere, Anne-Valérie Filleron, Thomas Valo, Isabelle Charon-Barra, Céline Robin, Yves-Marie Terrier, Philippe Chevreau, Christine and Coindre, Jean-Michel 2016. Malignant Peripheral Nerve Sheath Tumor Is a Challenging Diagnosis. The American Journal of Surgical Pathology, Vol. 40, Issue. 7, p. 896.


    Oblinger, Janet L. Burns, Sarah S. Akhmametyeva, Elena M. Huang, Jie Pan, Li Ren, Yulin Shen, Rulong Miles-Markley, Beth Moberly, Aaron C. Kinghorn, A. Douglas Welling, D. Bradley and Chang, Long-Sheng 2016. Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas. Neuro-Oncology, p. now032.


    Patel, Ami V. Chaney, Katherine E. Choi, Kwangmin Largaespada, David A. Kumar, Ashish R. and Ratner, Nancy 2016. An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors. EBioMedicine, Vol. 9, p. 110.


    Rueda-Arenas, Ernesto Pinilla-Orejarena, Adriana García-Corzo, Jorge Raúl and Lozano-Ortiz, Diana 2016. Tumor maligno de la vaina del nervio periférico retroperitoneal en un niño preescolar. Boletín Médico del Hospital Infantil de México, Vol. 73, Issue. 3, p. 188.


    Deyle, David R. Escobar, Diana Zarate Peng, Kah-Whye and Babovic-Vuksanovic, Dusica 2015. Oncolytic measles virus as a novel therapy for malignant peripheral nerve sheath tumors. Gene, Vol. 565, Issue. 1, p. 140.


    Kolberg, Matthias Høland, Maren Lind, Guro E. Ågesen, Trude H. Skotheim, Rolf I. Sundby Hall, Kirsten Mandahl, Nils Smeland, Sigbjørn Mertens, Fredrik Davidson, Ben and Lothe, Ragnhild A. 2015. Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours – A prognostic test after surgical resection. Molecular Oncology, Vol. 9, Issue. 6, p. 1129.


    Patel, Ami V. Johansson, Gunnar Colbert, Melissa C. Dasgupta, Biplab and Ratner, Nancy 2015. Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. Neuro-Oncology, Vol. 17, Issue. 12, p. 1599.


    Ratner, Nancy and Miller, Shyra J. 2015. A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nature Reviews Cancer, Vol. 15, Issue. 5, p. 290.


    Thomas, Laura E Winston, Jincy Rad, Ellie Mort, Matthew Dodd, Kayleigh M Tee, Andrew R McDyer, Fionnuala Moore, Stephen Cooper, David N and Upadhyaya, Meena 2015. Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours. Human Genomics, Vol. 9, Issue. 1, p. 3.


    Zhang, Pingyu Yang, Xianbin Ma, Xiaoyan Ingram, Davis R Lazar, Alexander J Torres, Keila E and Pollock, Raphael E 2015. Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway. Molecular Cancer, Vol. 14, Issue. 1, p. 55.


    Ikuta, Kunihiro Urakawa, Hiroshi Kozawa, Eiji Arai, Eisuke Zhuo, Lisheng Futamura, Naohisa Hamada, Shunsuke Kimata, Koji Ishiguro, Naoki and Nishida, Yoshihiro 2014. Hyaluronan expression as a significant prognostic factor in patients with malignant peripheral nerve sheath tumors. Clinical & Experimental Metastasis, Vol. 31, Issue. 6, p. 715.


    Martin-Liberal, Juan Benson, Charlotte and Judson, Ian 2014. New drugs in sarcomas. Expert Opinion on Pharmacotherapy, Vol. 15, Issue. 2, p. 221.


    Mullins, Brandon T. and Hackman, Trevor 2014. Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review. Case Reports in Otolaryngology, Vol. 2014, p. 1.


    Rauch, Anke Hennig, Dorle Schäfer, Claudia Wirth, Matthias Marx, Christian Heinzel, Thorsten Schneider, Günter and Krämer, Oliver H. 2014. Survivin and YM155: How faithful is the liaison?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1845, Issue. 2, p. 202.


    Wu, J Patmore, D M Jousma, E Eaves, D W Breving, K Patel, A V Schwartz, E B Fuchs, J R Cripe, T P Stemmer-Rachamimov, A O and Ratner, N 2014. EGFR–STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors. Oncogene, Vol. 33, Issue. 2, p. 173.


    Zhang, Pingyu Garnett, Jeannine Creighton, Chad J Al Sannaa, Ghadah Abbas Igram, Davis R Lazar, Alexander Liu, Xiuping Liu, Changgong and Pollock, Raphael E 2014. EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis. The Journal of Pathology, Vol. 232, Issue. 3, p. 308.


    Jessen, Walter J. Miller, Shyra J. Jousma, Edwin Wu, Jianqiang Rizvi, Tilat A. Brundage, Meghan E. Eaves, David Widemann, Brigitte Kim, Mi-Ok Dombi, Eva Sabo, Jessica Hardiman Dudley, Atira Niwa-Kawakita, Michiko Page, Grier P. Giovannini, Marco Aronow, Bruce J. Cripe, Timothy P. and Ratner, Nancy 2013. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. Journal of Clinical Investigation, Vol. 123, Issue. 1, p. 340.


    Weng, Yuxiong Chen, Yanhua Chen, Jianghai Liu, Yutian and Bao, Tengfei 2013. Identification of serum microRNAs in genome-wide serum microRNA expression profiles as novel noninvasive biomarkers for malignant peripheral nerve sheath tumor diagnosis. Medical Oncology, Vol. 30, Issue. 2,


    Agulnik, Mark 2012. New developments in mammalian target of rapamycin inhibitors for the treatment of sarcoma. Cancer, Vol. 118, Issue. 6, p. 1486.


    Andrychowski, Jarosław Czernicki, Zbigniew and Jasielski, Piotr 2012. Nerwiak osłonkowy nerwu strzałkowego wspólnego w obrębie dołu podkolanowego. Różnicowanie z torbielami zwyrodnieniowymi. Neurologia i Neurochirurgia Polska, Vol. 46, Issue. 4, p. 396.


    ×
  • Expert Reviews in Molecular Medicine, Volume 11
  • 2009, e30

Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways

  • Daniela Katz (a1), Alexander Lazar (a2) and Dina Lev (a3)
  • DOI: http://dx.doi.org/10.1017/S1462399409001227
  • Published online: 19 October 2009
Abstract

Malignant peripheral nerve sheath tumour (MPNST) is a rare malignancy accounting for 3–10% of all soft tissue sarcomas. Most MPNSTs arise in association with peripheral nerves or deep neurofibromas and may originate from neural crest cells, although the specific cell of origin is uncertain. Approximately half of MPNSTs occur in the setting of neurofibromatosis type 1 (NF1), an autosomal dominant disorder with an incidence of approximately one in 3500 persons; the remainder of MPNSTs develop sporadically. In addition to a variety of clinical manifestations, approximately 8–13% of NF1 patients develop MPNSTs, which are the leading cause of NF1-related mortality. Surgical resection is the mainstay of MPNST clinical management. However, because of invasive growth, propensity to metastasise, and limited sensitivity to chemotherapy and radiation, MPNST has a guarded to poor prognosis. Five-year survival rates of only 20–50% indicate an urgent need for improved therapeutic approaches. Recent work in this field has identified several altered intracellular signal transduction cascades and deregulated tyrosine kinase receptors, posing the possibility of personalised, targeted therapeutics. However, expanded knowledge of MPNST molecular pathobiology will be needed to meaningfully apply such approaches for the benefit of afflicted patients.

Copyright
Corresponding author
*Corresponding author: Dina Lev, Department of Cancer Biology and Sarcoma Research Center, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1104, Houston, TX 77030, USA. Tel: +1 713 792 1637; Fax: +1 713 563 1185; E-mail: dlev@mdanderson.org
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2D.V. Cashen (2004) Survival data for patients with malignant schwannoma. Clinical Orthopaedics and Related Research 426, 69-73

3M. Anghileri (2006) Malignant peripheral nerve sheath tumors: prognostic factors and survival in a series of patients treated at a single institution. Cancer 107, 1065-1074

4L. Angelov (1998) Neurogenic sarcomas: experience at the University of Toronto. Neurosurgery 43, 56-64; discussion 64-55

5D.G. Evans (2002) Malignant peripheral nerve sheath tumours in neurofibromatosis 1. Journal of Medical Genetics 39, 311-314

6B.S. Ducatman (1986) Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases. Cancer 57, 2006-2021

8T. Tucker (2005) Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology 65, 205-211

9J.M. Friedman (1999) Epidemiology of neurofibromatosis type 1. American Journal of Medical Genetics 89, 1-6

10D.H. Gutmann (1997) The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. Journal of the American Medical Association 278, 51-57

11G. Zadeh (2007) Radiation induced peripheral nerve tumors: case series and review of the literature. Journal of Neuro-Oncology 83, 205-212

13G. Gupta , A. Mammis and A. Maniker (2008) Malignant peripheral nerve sheath tumors. Neurosurgery Clinics of North America 19, 533-543

14J.N. Vauthey , J.M. Woodruff and M.F. Brennan (1995) Extremity malignant peripheral nerve sheath tumors (neurogenic sarcomas): a 10-year experience. Annals of Surgical Oncology 2, 126-131

15B.H. Van Herendael (2006) The value of magnetic resonance imaging in the differentiation between malignant peripheral nerve-sheath tumors and non-neurogenic malignant soft-tissue tumors. Skeletal Radiology 35, 745-753

16S. Cardona (2003) Evaluation of F18-deoxyglucose positron emission tomography (FDG-PET) to assess the nature of neurogenic tumours. European Journal of Surgical Oncology 29, 536-541

18B.T. Lin , L.M. Weiss and L.J. Medeiros (1997) Neurofibroma and cellular neurofibroma with atypia: a report of 14 tumors. American Journal of Surgical Pathology 21, 1443-1449

19C. Zou (2009) Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Annals of Surgery 249, 1014-1022

20T. De Raedt (2003) Elevated risk for MPNST in NF1 microdeletion patients. American Journal of Human Genetics 72, 1288-1292

21V.S. Warbey (2009) [18F]FDG PET/CT in the diagnosis of malignant peripheral nerve sheath tumours in neurofibromatosis type-1. European Journal of Nuclear Medicine and Molecular Imaging 36, 751-757

22D. Furniss (2008) A 10-year review of benign and malignant peripheral nerve sheath tumors in a single center: clinical and radiographic features can help to differentiate benign from malignant lesions. Plastic and Reconstructive Surgery 121, 529-533

24H.P. Kourea (1998) Subdiaphragmatic and intrathoracic paraspinal malignant peripheral nerve sheath tumors: a clinicopathologic study of 25 patients and 26 tumors. Cancer 82, 2191-2203

25W.W. Wong (1998) Malignant peripheral nerve sheath tumor: analysis of treatment outcome. International Journal of Radiation Oncology Biology Physics 42, 351-360

26S. Sharif (2006) Second primary tumors in neurofibromatosis 1 patients treated for optic glioma: substantial risks after radiotherapy. Journal of Clinical Oncology 24, 2570-2575

27P.P. Sordillo (1981) Malignant schwannoma–clinical characteristics, survival, and response to therapy. Cancer 47, 2503-2509

28M. Carli (2005) Pediatric malignant peripheral nerve sheath tumor: the Italian and German soft tissue sarcoma cooperative group. Journal of Clinical Oncology 23, 8422-8430

29A.N. D'Agostino , E.H. Soule and R.H. Miller (1963) Sarcomas of the Peripheral Nerves and Somatic Soft Tissues Associated with Multiple Neurofibromatosis (Von Recklinghausen's Disease). Cancer 16, 1015-1027

31A. Perry (2001) NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors. American Journal of Pathology 159, 57-61

32I. Bottillo (2009) Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours. Journal of Pathology 217, 693-701

33N. Holtkamp (2007) MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors. Neoplasia 9, 671-677

34A.G. Menon (1990) Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis. Proceedings of the National Academy of Sciences of the United States of America 87, 5435-5439

35S. Birindelli (2001) Rb and TP53 pathway alterations in sporadic and NF1-related malignant peripheral nerve sheath tumors. Laboratory Investigation 81, 833-844

36E. Legius (1994) TP53 mutations are frequent in malignant NF1 tumors. Genes Chromosomes and Cancer 10, 250-255

37C.M. Johannessen (2005) The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proceedings of the National Academy of Sciences of the United States of America 102, 8573-8578

38G. Ambrosini (2008) Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cells. Molecular Cancer Therapeutics 7, 890-896

39F. Perrone (2009) PDGFRA, PDGFRB, EGFR, and downstream signalling activation in malignant peripheral nerve sheath tumor. Neuro-Oncology Feb 26; [Epub ahead of print]

40M.A. Watson (2004) Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumors. Brain Pathology 14, 297-303

41Y.Y. Mahller (2006) Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants. Pediatric Blood and Cancer 46, 745-754

42R.R. Mattingly (2006) The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines. Journal of Pharmacology and Experimental Therapeutics 316, 456-465

43Y. Tang (1998) A role for Pak protein kinases in Schwann cell transformation. Proceedings of the National Academy of Sciences of the United States of America 95, 5139-5144

44D.A. Ingram (2001) Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. Journal of Experimental Medicine 194, 57-69

46S. Donovan (2002) Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells. Cancer Cell 2, 507-514

47N. Lau (2000) Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma. Journal of Neuropathology and Experimental Neurology 59, 759-767

48Y.Y. Zhang (1998) Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines. Journal of Experimental Medicine 187, 1893-1902

49N. Holtkamp (2008) EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy. Neuro-Oncology 10, 946-957

50C. Mawrin (2002) Immunohistochemical and molecular analysis of p53, RB, and PTEN in malignant peripheral nerve sheath tumors. Virchows Archiv 440, 610-615

51R. Schneider-Stock (1997) p53 gene mutations in soft-tissue sarcomas–correlations with p53 immunohistochemistry and DNA ploidy. Journal of Cancer Research and Clinical Oncology 123, 211-218

52L.G. Kindblom (1995) Immunohistochemical and molecular analysis of p53, MDM2, proliferating cell nuclear antigen and Ki67 in benign and malignant peripheral nerve sheath tumours. Virchows Archiv 427, 19-26

53H.P. Kourea (1999) Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas. American Journal of Pathology 155, 1855-1860

54G.P. Nielsen (1999) Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation. American Journal of Pathology 155, 1879-1884

55H.P. Kourea (1999) Expression of p27(kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: the emerging role of p27(kip) in malignant transformation of neurofibromas. American Journal of Pathology 155, 1885-1891

56A. Perry (2002) Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. Journal of Neuropathology and Experimental Neurology 61, 702-709

57K.K. Mantripragada (2008) High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization. Clinical Cancer Research 14, 1015-1024

58A. Theos and B.R. Korf (2006) Pathophysiology of neurofibromatosis type 1. Annals of Internal Medicine 144, 842-849

59R. Ballester (1990) The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63, 851-859

60G.F. Xu (1990) The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 63, 835-841

61G. Daum (1994) The ins and outs of Raf kinases. Trends in Biochemical Sciences 19, 474-480

63I. Rubio (1999) Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma. European Journal of Biochemistry 266, 70-82

64A.D. Basso , P. Kirschmeier and W.R. Bishop (2006) Lipid posttranslational modifications. Farnesyl transferase inhibitors. Journal of Lipid Research 47, 15-31

65S. Roy (2005) Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling. Molecular and Cellular Biology 25, 6722-6733

66W.W. Wong (2002) HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 16, 508-519

67M.A. Morgan , A. Ganser and C.W. Reuter (2003) Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia. Leukemia 17, 1482-1498

70J.W. Wojtkowiak (2008) Induction of apoptosis in neurofibromatosis type 1 malignant peripheral nerve sheath tumor cell lines by a combination of novel farnesyl transferase inhibitors and lovastatin. Journal of Pharmacology and Experimental Therapeutics 326, 1-11

71L.C. Krab (2008) Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial. Journal of the American Medical Association 300, 287-294

72J. Sun (1998) Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts. Oncogene 16, 1467-1473

73C.A. Rowell (1997) Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo. Journal of Biological Chemistry 272, 14093-14097

75B.C. Widemann (2006) Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas. Journal of Clinical Oncology 24, 507-516

76F. Chang (2003) Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17, 1263-1293

77J.N. Lavoie (1996) Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. Journal of Biological Chemistry 271, 20608-20616

78M.E. Katz and F. McCormick (1997) Signal transduction from multiple Ras effectors. Current Opinion in Genetics and Development 7, 75-79

79B.I. Rini (2007) Sunitinib. Expert Opinion on Pharmacotherapy 8, 2359-2369

81G. Diwakar (2008) Neurofibromin as a regulator of melanocyte development and differentiation. Journal of Cell Science 121, 167-177

82J.T. Dilworth (2006) Molecular targets for emerging anti-tumor therapies for neurofibromatosis type 1. Biochemical Pharmacology 72, 1485-1492

83G. Johansson (2008) Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Molecular Cancer Therapeutics 7, 1237-1245

84D.A. Guertin and D.M. Sabatini (2005) An expanding role for mTOR in cancer. Trends in Molecular Medicine 11, 353-361

85J. LoPiccolo (2008) Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resistance Updates 11, 32-50

86C.Y. Zou (2009) Dual targeting of AKT and mammalian target of rapamycin: A potential therapeutic approach for malignant peripheral nerve sheath tumor. Molecular Cancer Therapeutics May 5; [Epub ahead of print]

87C. Vezina , A. Kudelski and S.N. Sehgal (1975) Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. Journal of Antibiotics 28, 721-726

89X. Wan and L.J. Helman (2007) The biology behind mTOR inhibition in sarcoma. Oncologist 12, 1007-1018

90M. Guba (2002) Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nature Medicine 8, 128-135

91S.Y. Sun (2005) Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Research 65, 7052-7058

92X. Wang (2007) Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation. Molecular and Cellular Biology 27, 7405-7413

93M.M. Mita (2008) Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies. Journal of Clinical Oncology 26, 361-367

97F.I. Raynaud (2007) Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. Cancer Research 67, 5840-5850

99Y. Yarden (2001) The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. European Journal of Cancer 37 (Suppl 4), S3-8

100J.E. DeClue (2000) Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models. Journal of Clinical Investigation 105, 1233-1241

101H. Tawbi (2008) Epidermal growth factor receptor expression and mutational analysis in synovial sarcomas and malignant peripheral nerve sheath tumors. Oncologist 13, 459-466

104B.C. Ling (2005) Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell 7, 65-75

105N. Holtkamp (2004) Subclassification of nerve sheath tumors by gene expression profiling. Brain Pathology 14, 258-264

106D. Keizman (2009) Expression and significance of EGFR in malignant peripheral nerve sheath tumor. Journal of Neuro-Oncology 94, 383-388

107E. Raymond , S. Faivre and J.P. Armand (2000) Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy. Drugs 60 (Suppl 1), 15-23; discussion 41-12

108W. Su (2003) Malignant peripheral nerve sheath tumor cell invasion is facilitated by Src and aberrant CD44 expression. Glia 42, 350-358

109Y.Y. Mahller (2007) Oncolytic HSV and erlotinib inhibit tumor growth and angiogenesis in a novel malignant peripheral nerve sheath tumor xenograft model. Molecular Therapy 15, 279-286

110R.S. Herbst (2002) Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial. Journal of Clinical Oncology 20, 3815-3825

111S. Benvenuti (2007) Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Research 67, 2643-2648

112N. van Zandwijk (2007) EGFR and KRAS mutations as criteria for treatment with tyrosine kinase inhibitors: retro- and prospective observations in non-small-cell lung cancer. Annals of Oncology 18, 99-103

113F. Perrone (2009) PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Annals of Oncology 20, 84-90

114M. Frattini (2007) PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. British Journal of Cancer 97, 1139-1145

115C.E. Geyer (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. New England Journal of Medicine 355, 2733-2743

116C.H. Heldin and B. Westermark (1984) Growth factors: mechanism of action and relation to oncogenes. Cell 37, 9-20

117C. Betsholtz , L. Karlsson and P. Lindahl (2001) Developmental roles of platelet-derived growth factors. Bioessays 23, 494-507

118A. Badache and G.H. De Vries (1998) Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB. Journal of Cellular Physiology 177, 334-342

119N. Holtkamp (2004) Differentially expressed genes in neurofibromatosis 1-associated neurofibromas and malignant peripheral nerve sheath tumors. Acta Neuropathologica 107, 159-168

120N. Holtkamp (2006) Mutation and expression of PDGFRA and KIT in malignant peripheral nerve sheath tumors, and its implications for imatinib sensitivity. Carcinogenesis 27, 664-671

121I. Dang and G.H. DeVries (2005) Schwann cell lines derived from malignant peripheral nerve sheath tumors respond abnormally to platelet-derived growth factor-BB. Journal of Neuroscience Research 79, 318-328

122S.M. Jones and A. Kazlauskas (2000) Connecting signaling and cell cycle progression in growth factor-stimulated cells. Oncogene 19, 5558-5567

123M. Aoki (2007) Imatinib mesylate inhibits cell invasion of malignant peripheral nerve sheath tumor induced by platelet-derived growth factor-BB. Laboratory Investigation 87, 767-779

125A. Badache , N. Muja and G.H. De Vries (1998) Expression of Kit in neurofibromin-deficient human Schwann cells: role in Schwann cell hyperplasia associated with type 1 neurofibromatosis. Oncogene 17, 795-800

126K.M. Reilly and T. Van Dyke (2008) It takes a (dysfunctional) village to raise a tumor. Cell 135, 408-410

127Y. Zhu (2002) Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science 296, 920-922

128S. DuBois and G. Demetri (2007) Markers of angiogenesis and clinical features in patients with sarcoma. Cancer 109, 813-819

129D.J. Hicklin and L.M. Ellis (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Journal of Clinical Oncology 23, 1011-1027

130S.J. Harper and D.O. Bates (2008) VEGF-A splicing: the key to anti-angiogenic therapeutics? Nature Reviews Cancer 8, 880-887

131J. Wasa (2008) Differential expression of angiogenic factors in peripheral nerve sheath tumors. Clinical and Experimental Metastasis 25, 819-825

133D.R. D'Adamo (2005) Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas. Journal of Clinical Oncology 23, 7135-7142

135M.L. Hensley (2002) Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: results of a phase II trial. Journal of Clinical Oncology 20, 2824-2831

S.R. Grobmyer (2008) Malignant peripheral nerve sheath tumor: molecular pathogenesis and current management considerations. Journal of Surgical Oncology 97, 340-349

J.B. Rubin and D.H. Gutmann (2005) Neurofibromatosis type 1 – a model for nervous system tumour formation? Nature Reviews Cancer 5, 557-564

A. Gschwind , O.M. Fischer and A. Ullrich (2004) The discovery of receptor tyrosine kinases: targets for cancer therapy. Nature Reviews Cancer 4, 361-370

J.S. Sebolt-Leopold and R. Herrera (2004) Targeting the mitogen-activated protein kinase cascade to treat cancer. Nature Reviews Cancer 4, 937-947

D.M. Sabatini (2006) mTOR and cancer: insights into a complex relationship. Nature Reviews Cancer 6, 729-734

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Expert Reviews in Molecular Medicine
  • ISSN: -
  • EISSN: 1462-3994
  • URL: /core/journals/expert-reviews-in-molecular-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×