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MicroRNA-181a – a tale of discrepancies

  • Aliaa M. Seoudi (a1), Yasmine A. Lashine (a1) and Ahmed I. Abdelaziz (a1)
Abstract

MicroRNAs (miRNAs) are short noncoding RNAs that act as post-transcriptional regulators. The low complementarity required between the sequences of a miRNA and its target mRNA enables a single miRNA to act on a large range of targets. Thus miRNAs have an intersecting complex effect that spans a multiplicity of pathways and processes. In this review, the different roles of a vital miRNA, miR-181a, in physiological and pathological developments are collated in an attempt to highlight the intersections of such processes and to show how the deregulation of miR-181a could in one context drive malignancy, whereas in another it can lead to autoimmunity. Such deregulation could be related to the faulty levels of one of its own targets, p53, which was recently reported to control an array of miRNAs, one of which is miR-181a. This sheds light on a hidden loop of chaos behind chronic diseases such as autoimmunity and cancer.

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Corresponding author
*Corresponding author: Ahmed I. Abdelaziz, The German University in Cairo – GUC, New Cairo City – Main Entrance of Al Tagamoa Al Khames, 11835 Cairo, Egypt. E-mail: abdel-aziz@guc.edu.eg
References
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1Ohno S. (1972) So much ‘junk’ DNA in our genome. Evolution of Genetic Systems (Smith H. H. ed), pp. 366-370, Gordon and Breach, New York, USA
2Lewis B.P. et al. (2003) Prediction of Mammalian MicroRNA Targets. Cell 115, 787-798
3Calin G.A. and Croce C.M. (2006) MicroRNA signatures in human cancers. Natures Reviews Cancer 6, 857-866
4Lashine Y.A. et al. (2011) Expression signature of microRNA-181-a reveals its crucial role in the pathogenesis of paediatric systemic lupus erythematosus. Clinical and Experimental Rheumatology 29, 351-357
5Lim L.P. et al. (2005) Microarray analysis shows that some microRNAs downregulate a large number of target mRNAs. Nature 433, 769-773
6Huang S. et al. (2010) MicroRNA-181a modulates gene expression of zinc finger family members by directly targeting their coding regions. Nucleic Acids Research 38, 7211-7218.
7Chng Z. et al. (2010) SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell 6, 59-70
8Shaw L., Johnson P.A. and Kimber S.J. (2010) Gene expression profiling of the developing mouse kidney and embryo. In Vitro Cellular and Developmental Biology. Animal 46, 155-165
9Seuntjens E. et al. (2009) Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors. Nature Neuroscience 12, 1373-1380
10Yoshimoto A. et al. (2005) Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. Development 132, 4437-4448
11Peinado H., Olmeda D. and Cano A. (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nature Reviews Cancer 7, 415-428
12Saunders L.R. et al. (2010) miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) 2, 415-431
13Ryan D.G., Oliveira-Fernandes M. and Lavker R.M. (2006) MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity. Molecular Vision 12, 1175-1184
14Ji J. et al. (2009) Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 50, 472-480
15Pan Q. et al. (2007) The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression. Molecular Human Reproduction 13, 797-806
16Li Y.G. et al. (2009) Knockdown of microRNA-181 by lentivirus mediated siRNA expression vector decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction. Microvascular Research 78, 393-404
17Safdar A. et al. (2009) miRNA in the regulation of skeletal muscle adaptation to acute endurance exercise in C57Bl/6J male mice. PLoS One 4, e5610
18Kazenwadel J., Michael M.Z. and Harvey N.L. (2010) Prox1 expression is negatively regulated by miR-181 in endothelial cells. Blood 116, 2395-2401
19Chen C.Z. et al. (2004) MicroRNAs modulate hematopoietic lineage differentiation. Science 303, 83-86
20Ramkissoon S.H. et al. (2006) Hematopoietic-specific microRNA expression in human cells. Leukemia Research 30, 643-647
21Okada H., Kohanbash G. and Lotze M.T. (2010) MicroRNAs in immune regulation – opportunities for cancer immunotherapy. International Journal of Biochemistry and Cell Biology 42, 1256-1261
22Ebert P.J. et al. (2009) An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nature Immunology 10, 1162-1169
23Neilson J.R. et al. (2007) Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes and Development 21, 578-589
24Liu G. et al. (2008) Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development. PLoS One 3, e3592
25Li Q.J. et al. (2007) miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 129, 147-161
26Dittel B.N. et al. (1999) Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity 11, 289-298
27Stefanova I. et al. (2003) TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nature Immunology 4, 248-254
28Altan-Bonnet G. and Germain R.N. (2005) Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biology 3, e356
29Choong M.L., Yang H.H. and McNiece I. (2007) MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis. Experimental Hematology 35, 551-564
30Gao W. et al. (2011) MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis. Journal of Cancer Research and Clinical Oncology 137, 557-566
31Shin K.H. et al. (2011) miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras. Biochemical and Biophysical Research Communications 404, 896-902
32Caulin C. et al. (2004) Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity. Cancer Research 64, 5054-5058
33Gao W. et al. (2010) Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis. Biomedicine and Pharmacotherapy 64, 399-408
34Cheng A.M. et al. (2005) Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Research 33, 1290-1297
35Fei J. et al. (2008) Inhibitory effects of anti-miRNA oligonucleotides (AMOs) on A549 cell growth. Journal of Drug Targeting 16, 688-693
36Galluzzi L. et al. (2010) miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Research 70, 1793-1803
37Ciafre S.A. et al. (2005) Extensive modulation of a set of microRNAs in primary glioblastoma. Biochemical and Biophysical Research Communications 334, 1351-1358
38Shi L. et al. (2008) hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells. Brain Research 1236, 185-193
39Chen G. et al. (2010) MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2. Oncology Reports 23, 997-1003
40Wald A.I. et al. (2010) Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus. Head and Neck 33, 504-512
41Miller T.E. et al. (2008) MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1. Journal of Biological Chemistry 283, 29897-29903
42Wang Y. et al. (2010) Transforming growth factor-beta regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. Oncogene 30, 1470-1480
43Maillot G. et al. (2009) Widespread estrogen-dependent repression of micrornas involved in breast tumor cell growth. Cancer Research 69, 8332-8340
44Debernardi S. et al. (2007) MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis. Leukemia 21, 912-916
45Pons A. et al. (2009) Hematopoiesis-related microRNA expression in myelodysplastic syndromes. Leukemia and Lymphoma 50, 1854-1859
46Wang Y. et al. (2010) MicroRNAs expression signatures are associated with lineage and survival in acute leukemias. Blood Cells, Molecules and Diseases 44, 191-197
47Zimmerman E.I. et al. (2010) Lyn kinase-dependent regulation of miR181 and Mcl-1 expression: implications for drug resistance in myelogenous leukemia. Molecular Pharmacology 78, 811-817
48Pichiorri F. et al. (2008) MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 105, 12885-12890
49Lwin T. et al. (2010) Follicular dendritic cell-dependent drug resistance of non-Hodgkin lymphoma involves cell adhesion-mediated Bim down-regulation through induction of microRNA-181a. Blood 116, 5228-5236
50Mortarino M. et al. (2010) Identification of suitable endogenous controls and differentially expressed microRNAs in canine fresh-frozen and FFPE lymphoma samples. Leukemia Research 34, 1070-1077
51Marton S. et al. (2008) Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. Leukemia 22, 330-338
52Visone R. et al. (2009) Karyotype-specific microRNA signature in chronic lymphocytic leukemia. Blood 114, 3872-3879
53Calin G.A., Pekarsky Y. and Croce C.M. (2007) The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia. Best Practice and Research. Clinical Haematology 20, 425-437
54Pallasch C.P. et al. (2009) miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia. Blood 114, 3255-3264
55Pizzimenti S. et al. (2009) MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation. Free Radical Biology and Medicine 46, 282-288
56Zhou J.Y. et al. (2006) Effects of microRNA miR-181a on gene expression profiles of K562 cells. Nan Fang Yi Ke Da Xue Xue Bao 26, 606-609
57Wang X. et al. (2009) MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3. Cell Cycle 8, 736-741
58Vinuesa C.G., Rigby R.J. and Yu D. (2009) Logic and extent of miRNA-mediated control of autoimmune gene expression. International Review of Immunology 28, 112-138
59Te J.L. et al. (2010) Identification of unique microRNA signature associated with lupus nephritis. PLoS One 5, e10344
60Boominathan L. (2010) The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex. PLoS One 5, e10615
61Tarasov V. et al. (2007) Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 6, 1586-1593
62Tsang J., Zhu J. and van Oudenaarden A. (2007) MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Molecular Cell 26, 753-767
63Nuorva K. et al. (1993) Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas. American Journal of Pathology 142, 725-732
64Fontanini G. et al. (1994) Human non-small cell lung cancer: p53 protein accumulation is an early event and persists during metastatic progression. Journal of Pathology 174, 23-31
65Gross M.W. et al. (2005) Expression of p53 and p21 in primary glioblastomas. Strahlentherapie und Onkologie 181, 164-171
66El-Sayed Z.A., Farag D.H. and Eissa S. (2003) Tumor suppressor protein p53 and anti-p53 autoantibodies in pediatric rheumatological diseases. Pediatric Allergy and Immunology 14, 229-233
67Kataoka M. et al. (2000) Down-regulation of bcl-2 is associated with p16INK4-mediated apoptosis in non-small cell lung cancer cells. Oncogene 19, 1589-1595
68Xu G.W. et al. (2001) Inactivation of p53 sensitizes U87MG glioma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Research 61, 4155-4159
69Balz V. et al. (2003) Is the p53 inactivation frequency in squamous cell carcinomas of the head and neck underestimated? Analysis of p53 exons 2-11 and human papillomavirus 16/18 E6 transcripts in 123 unselected tumor specimens. Cancer Research 63, 1188-1191
70Markovic O. et al. (2007) The expression of p53 protein in patients with multiple myeloma. Srpski arhiv za Celokupno lekarstvo 135, 43-47
71Liu J. et al. (1999) The expression of p53 tumor suppressor gene in breast cancer cells is down-regulated by cytokine oncostatin M. Cell Growth and Differentiation 10, 677-683
72Bovenkerk S., Lanciloti N. and Chandar N. (2003) Induction of p53 expression and function by estrogen in osteoblasts. Calcified Tissue International 73, 274-280
73Esau C. et al. (2004) MicroRNA-143 regulates adipocyte differentiation. Journal of Biological Chemistry 279, 52361-52365
74Stenvang J. et al. (2008) The utility of LNA in microRNA-based cancer diagnostics and therapeutics. Seminars in Cancer Biology 18, 89-102
75Naguibneva I. et al. (2006) An LNA-based loss-of-function assay for micro-RNAs. Biomedicine and Pharmacotherapy 60, 633-638
76Orom U.A., Kauppinen S. and Lund A.H. (2006) LNA-modified oligonucleotides mediate specific inhibition of microRNA function. Gene 372, 137-141
77Esau C. et al. (2006) miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metabolism 3, 87-98
78Krutzfeldt J. et al. (2005) Silencing of microRNAs in vivo with ‘antagomirs’. Nature 438, 685-689
79Ebert M.S., Neilson J.R. and Sharp P.A. (2007) MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nature Methods 4, 721-726
80Choi W.Y., Giraldez A.J. and Schier A.F. (2007) Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science 318, 271-274
81Xiao J. et al. (2007) Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes HCN2 and HCN4. Journal of Cellular Physiology 212, 285-292
82Hua Z. et al. (2006) MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One 1, e116
83Landen C.N. Jr. et al. (2005) Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Research 65, 6910-6918
84Lu C. et al. (2010) Regulation of tumor angiogenesis by EZH2. Cancer Cell 18, 185-197
85Shahzad M.M. et al. (2011) Targeted delivery of small interfering RNA using reconstituted high-density lipoprotein nanoparticles. Neoplasia 13, 309-319
86Yamamoto J. et al. (2003) Primary esophageal small cell carcinoma with concomitant invasive squamous cell carcinoma or carcinoma in situ. Human Pathology 34, 1108-1115
87Miura N. et al. (2009) Clinicopathological significance of Sip1-associated epithelial mesenchymal transition in non-small cell lung cancer progression. Anticancer Research 29, 4099-4106
88Chelidonis G. et al. (2009) DNA ploidy, E-cadherin, beta-catenin expression and their clinicopathologic significance in imprints of non-small cell lung cancer. Analytical and Quantitative Cytology and Histology 31, 332-339
89Zhu J. et al. (2010) [The relationships between cyclin D1 expression and prognosis of non-small cell lung cancer]. Zhongguo Fei Ai Za Zhi 13, 803-808
90Sun S.Y. et al. (2001) Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochemical and Biophysical Research Communications 280, 788-797
91Tang C. et al. (2010) [Expression and its clinical significance of SHP2 in non-small cell lung cancer]. Zhongguo Fei Ai Za Zhi 13, 98-101
92Catzavelos C. et al. (1999) Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: a prognostic factor independent of Ras. Cancer Research 59, 684-688
93Gautschi O. et al. (2007) Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. Lung Cancer 55, 1-14
94Elsir T. et al. (2010) Expression of PROX1 Is a common feature of high-grade malignant astrocytic gliomas. Journal of Neuropathology and Experimental Neurology 69, 129-138
95Stegh A.H. et al. (2010) Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes and Development 24, 2194-2204
96Wintterle S. et al. (2003) Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. Cancer Research 63, 7462-7467
97Piva R. et al. (1997) p27/kip1 expression in human astrocytic gliomas. Neuroscience Letters 234, 127-130
98Andre J. et al. (2007) Overexpression of the antiapoptotic gene Bfl-1 in B cells from patients with familial systemic lupus erythematosus. Lupus 16, 95-100
99Gomez-Martin D. et al. Quantitative and functional profiles of CD4+ lymphocyte subsets in systemic lupus erythematosus patients with lymphopenia. Clinical and Experimental Immunology 164, 17-25
100Hillion S. et al. (2007) Interleukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus. Immunology 122, 371-380
101Akimoto T. et al. (1998) Effect of radiation on the expression of E-cadherin and alpha-catenin and invasive capacity in human lung cancer cell line in vitro. International Journal of Radiative Oncology, Biology, Physics 41, 1171-1176
102Driscoll B. et al. (1997) Cyclin D1 antisense RNA destabilizes pRb and retards lung cancer cell growth. American Journal of Physiology 273, L941-L949
103Cheng Q. et al. (2000) Upregulation of Bcl-x and Bfl-1 as a potential mechanism of chemoresistance, which can be overcome by NF-kappaB inhibition. Oncogene 19, 4936-4940
104Niu Q. et al. (2011) Cord blood-derived cytokine-induced killer cells biotherapy combined with second-line chemotherapy in the treatment of advanced solid malignancies. International Immunopharmacology 11, 449-456
105Shin S.Y. et al. (2004) Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells. Experimental and Molecular Medicine 36, 380-386
106Narita Y. et al. (2002) Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas. Cancer Research 62, 6764-6769
107Ebrahimi M. et al. (2008) Decreased expression of the p63 related proteins beta-catenin, E-cadherin and EGFR in oral lichen planus. Oral Oncology 44, 634-638
108Akervall J.A. et al. (1997) Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression. Cancer 79, 380-389
109Hager G. et al. (2001) 1,25(OH)2 vitamin D3 induces elevated expression of the cell cycle-regulating genes P21 and P27 in squamous carcinoma cell lines of the head and neck. Acta Oto-laryngologica 121, 103-109
110Van den Hove L.E. et al. (1998) Peripheral blood lymphocyte subset shifts in patients with untreated hematological tumors: evidence for systemic activation of the T cell compartment. Leukemia Research 22, 175-184
111Said J.W. et al. (2001) TCL1 oncogene expression in B cell subsets from lymphoid hyperplasia and distinct classes of B cell lymphoma. Laboratory Investigation 81, 555-564
112Shaughnessy J. (2005) Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27Kip1 and an aggressive clinical course in multiple myeloma. Hematology 10, 117-126
113Liu X. and Feng R. (2010) Inhibition of epithelial to mesenchymal transition in metastatic breast carcinoma cells by c-Src suppression. Acta Biochimica et Biophysica Sinica 42, 496-501
114Ye Y. et al. (2010) E-cadherin accumulation within the lymphovascular embolus of inflammatory breast cancer is due to altered trafficking. Anticancer Research 30, 3903-3910
115Zwijsen R.M. et al. (1996) Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit. Molecular and Cellular Biology 16, 2554-2560
116Hu T. et al. (2008) Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Research 68, 6533-6540
117Rasmussen U.B. et al. (1993) Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. Cancer Research 53, 4096-4101
118Zhao H. et al. (2009) The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells. Blood 113, 505-516
119Petrocca F. et al. (2008) E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13, 272-286

Published miRNA sequences, annotations, predicted hairpin portions of miRNA transcripts, information on the location and sequence of the mature miRNA sequence and hairpin and mature sequences:

Tsang J., Zhu J. and van Oudenaarden A. (2007) MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. Molecular Cell 26, 753-767
Tili E. et al. (2007) miRNAs and their potential for use against cancer and other diseases. Future Oncology 3, 521-537
Zhang X. and Lu X. (2011) Posttranscriptional regulation of miRNAs in the DNA damage response. RNA Biology 8, 960-963
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