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Antibiotic use in Canadian neonatal intensive care units: a national survey for developing antimicrobial stewardship targets

Published online by Cambridge University Press:  14 June 2023

Lindsay L. Richter
Affiliation:
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Matthew Sai-pong Ho
Affiliation:
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Michael S. Dunn
Affiliation:
Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
Kyong-Soon Lee
Affiliation:
Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
Joan L. Robinson
Affiliation:
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Ashley Roberts
Affiliation:
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Nisha Thampi
Affiliation:
Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
Shikha Gupta-Bhatnagar
Affiliation:
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Prakesh S. Shah
Affiliation:
Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada
Joseph Y. Ting*
Affiliation:
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
*
Corresponding author: Joseph Y. Ting; Email: Joseph.ting@ualberta.ca

Abstract

A survey was conducted among Canadian tertiary neonatal intensive care units. Of the 27 sites who responded, 9 did not have any form of antimicrobial stewardship, and 11 used vancomycin for empirical coverage in late-onset-sepsis evaluations. We detected significant variations in the diagnostic criteria for urinary tract infection and ventilator-associated pneumonia.

Type
Concise Communication
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Ting, JY, Autmizguine, J, Dunn, MS, et al. Practice summary of antimicrobial therapy for commonly encountered conditions in the neonatal intensive care unit: a Canadian perspective. Front Pediatr 2022;10:894005.10.3389/fped.2022.894005CrossRefGoogle ScholarPubMed
Ting, JY, Roberts, A, Abou Mehrem, A, et al. Variability in antimicrobial use among infants born at <33 weeks gestational age. Infect Control Hosp Epidemiol 2023;44:128132.10.1017/ice.2021.380CrossRefGoogle ScholarPubMed
Ericson, JE, Thaden, J, Cross, HR, et al. No survival benefit with empirical vancomycin therapy for coagulase-negative staphylococcal bloodstream infections in infants. Pediatr Infect Dis J 2015;34:371375.10.1097/INF.0000000000000573CrossRefGoogle ScholarPubMed
Solomkin, JS, Mazuski, JE, Bradley, JS, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 2010;50:133164.10.1086/649554CrossRefGoogle ScholarPubMed
Autmizguine, J, Hornik, CP, Benjamin, DK Jr, et al. Anaerobic antimicrobial therapy after necrotizing enterocolitis in VLBW infants. Pediatrics 2015;135:e117e125.10.1542/peds.2014-2141CrossRefGoogle ScholarPubMed
Canadian Neonatal Network Report Review Committee. 2021 Annual Report. Canadian Neonatal Network website. http://www.canadianneonatalnetwork.org/portal/Portals/0/Annual%20Reports/2021%20CNN%20annual%20report%20final_amended.pdf. Accessed May 31, 2023.Google Scholar
Nakashima, T, Inoue, H, Sakemi, Y, Yamashita, H. Effectiveness of umbilical culture for surveillance of methicillin-resistant Staphylococcus aureus among neonates admitted to neonatal intensive care units. Infect Control Hosp Epidemiol 2022. doi: 10.1017/ice.2022.150.Google ScholarPubMed
Heigl, K, Zamfir, M, Adler, AC, et al. Prevalence of methicillin-sensitive, methicillin-resistant Staphylococcus aureus, and extended-spectrum beta-lactamase–producing Escherichia coli in newborns: a cross-sectional study. J Matern Fetal Neonatal Med 2022;35:42434249.10.1080/14767058.2020.1849100CrossRefGoogle ScholarPubMed
Subcommittee On Urinary Tract I. Reaffirmation of AAP clinical practice guideline: the diagnosis and management of the initial urinary tract infection in febrile infants and young children 2–24 months of age. Pediatrics 2016;138:e20163026.10.1542/peds.2016-3026CrossRefGoogle Scholar
Ting, JY, Roberts, A, Tilley, P, et al. Development of a national neonatal intensive care unit-specific antimicrobial stewardship programme in Canada: protocol for a cohort study. BMJ Open 2020;10:e043403.10.1136/bmjopen-2020-043403CrossRefGoogle ScholarPubMed
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