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SHEA Neonatal Intensive Care Unit (NICU) White Paper Series: Practical approaches for the prevention of central-line–associated bloodstream infections

Published online by Cambridge University Press:  04 March 2022

Martha Muller
Pediatric Infectious Disease, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States UNM Health Sciences, Albuquerque, New Mexico, United States
Kristina A. Bryant*
Pediatric Infectious Diseases, University of Louisville, Louisville, Kentucky, United States Norton Children’s Hospital, Louisville, Kentucky, United States
Claudia Espinosa
Pediatric Infectious Diseases, University of South Florida Morsani College of Medicine, Tampa, Florida, United States
Jill A. Jones
Nationwide Children’s Hospital, Columbus, Ohio, United States
Caroline Quach
Departments of Microbiology, Infectious Diseases and Immunology and Pediatrics, University of Montreal, Montreal, Québec, Canada Clinical Department of Laboratory Medicine, CHU Sainte-Justine, Québec, Canada
Jessica R. Rindels
Children’s Mercy Hospital, Kansas City, Missouri, United States
Dan L. Stewart
Norton Children’s Hospital, Louisville, Kentucky, United States University of Louisville School of Medicine, Louisville, Kentucky, United States
Kenneth M. Zangwill
Division of Pediatric Infectious Diseases and Department of Infection Prevention and Control, Harbor-UCLA Medical Center, Torrance, California, United States
Pablo J. Sánchez
Divisions of Neonatology and Pediatric Infectious Diseases, Department of Pediatrics, Nationwide Children’s Hospital, Columbus, Ohio, United States Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States
Corresponding author: Kristina A. Bryant, MD, E-mail:


This document is part of the “SHEA Neonatal Intensive Care Unit (NICU) White Paper Series.” It is intended to provide practical, expert opinion, and/or evidence-based answers to frequently asked questions about CLABSI detection and prevention in the NICU. This document serves as a companion to the CDC Healthcare Infection Control Practices Advisory Committee (HICPAC) Guideline for Prevention of Infections in Neonatal Intensive Care Unit Patients. Central line-associated bloodstream infections (CLABSIs) are among the most frequent invasive infections among infants in the NICU and contribute to substantial morbidity and mortality. Infants who survive CLABSIs have prolonged hospitalization resulting in increased healthcare costs and suffer greater comorbidities including worse neurodevelopmental and growth outcomes. A bundled approach to central line care practices in the NICU has reduced CLABSI rates, but challenges remain. This document was authored by pediatric infectious diseases specialists, neonatologists, advanced practice nurse practitioners, infection preventionists, members of the HICPAC guideline-writing panel, and members of the SHEA Pediatric Leadership Council. For the selected topic areas, the authors provide practical approaches in question-and-answer format, with answers based on consensus expert opinion within the context of the literature search conducted for the companion HICPAC document and supplemented by other published information retrieved by the authors. Two documents in the series precede this one: “Practical approaches to Clostridioides difficile prevention” published in August 2018 and “Practical approaches to Staphylococcus aureus prevention,” published in September 2020.

SHEA White Paper
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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