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Can Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF) Enhance Antimicrobial Stewardship Efforts in the Acute Care Setting?

  • Pranita D. Tamma (a1), Kennard Tan (a2), Veronique R. Nussenblatt (a3), Alison E. Turnbull (a4), Karen C. Carroll (a5) and Sara E. Cosgrove (a3)...


We evaluated 222 hospitalized patients whose clinical isolates were tested using standard methods and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF). MALDI-TOF could have reduced time to appropriate therapy for 28.8% and 44.6% patients based on the treating physician's choices and stewardship team recommendations, respectively. Clinicians should be aware of scenarios in which MALDI-TOF can optimize antibiotic therapy.


Corresponding author

Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Medical Institutions, 200 North Wolfe Street, Suite 3155, Baltimore, MD 21287 (


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