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Enhanced disinfection leads to reduction of microbial contamination and a decrease in patient colonization and infection

  • William A. Rutala (a1) (a2), Hajime Kanamori (a2) (a3), Maria F. Gergen (a1), Lauren P. Knelson (a4), Emily E. Sickbert-Bennett (a1) (a2), Luke F. Chen (a4), Deverick J. Anderson (a4), Daniel J. Sexton (a4), David J. Weber (a1) (a2) and the CDC Prevention Epicenters Program (a1) (a2) (a3) (a4)...


In this prospective study, we monitored 4 epidemiologically important pathogens (EIPs): methicillin-resistane Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Clostridium difficile, and multidrug-resistant (MDR) Acinetobacter to assess the effectiveness of 3 enhanced disinfection strategies for terminal room disinfection against standard practice. Our data demonstrated that a decrease in room contamination with EIPs of 94% was associated with a 35% decrease in subsequent patient colonization and/or infection.


Corresponding author

Author for correspondence: William A. Rutala, PhD, MPH, CIC, Division of Infectious Diseases, UNC School of Medicine, Bioinformatics Building, CB#7030, 130 Mason Farm Road, Chapel Hill, NC 27514-7030. E-mail:


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