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High Prevalence of Reduced Chlorhexidine Susceptibility in Organisms Causing Central Line–Associated Bloodstream Infections

  • Nuntra Suwantarat (a1), Karen C. Carroll (a1) (a2), Tsigereda Tekle (a2), Tracy Ross (a2), Lisa L. Maragakis (a3) (a4), Sara E. Cosgrove (a3) (a4) and Aaron M. Milstone (a4) (a5)...

In units that bathe patients daily with chlorhexidine gluconate (CHG), organisms causing central line–associated bloodstream infections (CLABSIs) were more likely to have reduced CHG susceptibility than organisms causing CLABSIs in units that do not bathe patients daily with CHG (86% vs 64%; P = .028). Surveillance is needed to detect reduced CHG susceptibility with widespread CHG use.

Infect Control Hosp Epidemiol 2014;35(9):1183-1186

Corresponding author
Division of Medical Microbiology, Johns Hopkins University School of Medicine, Meyer B1-193, 600 North Wolfe Street, Baltimore, MD 21287 (
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, , , . . ;:–.1. AM Milstone A Elward X Song et alDaily chlorhexidine bathing to reduce bacteraemia in critically ill children: a multicentre, cluster-randomised, crossover trial Lancet 2013 381 10991106

, , , . . ;:–.2. MW Climo DS Yokoe DK Warren et alEffect of daily chlorhexidine bathing on hospital-acquired infection N Engl J Med 2013 368 533542

, , . ? ;:–.3. C Horner D Mawer M Wilcox Reduced susceptibility to chlorhexidine in staphylococci: is it increasing and does it matter J Antimicrob Chemother 2012 67 25472559

, , , . . ;:–.4. A Apisarnthanarak L Yang Hsu TP Lim LM Mundy Increase in chlorhexidine minimal inhibitory concentration of Acinetobacter baumannii clinical isolates after implementation of advanced source control Infect Control Hosp Epidemiol 2014 35 9899

, , , . . ;:–.5. CS Higgins SM Murtough E Williamson et alResistance to antibiotics and biocides among non-fermenting gram-negative bacteria Clin Microbiol Infect 2001 7 308315

, , , . . ;:–.7. MM Alam N Kobayashi N Uehara et alAnalysis on distribution and genomic diversity of high-level antiseptic resistance genes qacA and qacB in human clinical isolates of Staphylococcus aureus Microb Drug Resist 2003 9 109121

, , , . . ;:–.8. M Grare HM Dibama S Lafosse et alCationic compounds with activity against multidrug-resistant bacteria: interest of a new compound compared with two older antiseptics, hexamidine and chlorhexidine Clin Microbiol Infect 2010 16 432438

, , . . ;:–.9. S Kõljalg P Naaber M Mikelsaar Antibiotic resistance as an indicator of bacterial chlorhexidine susceptibility J Hosp Infect 2002 51 106113

, , , , , . . ;:–.10. JA Otter A Patel PR Cliff EP Halligan O Tosas JD Edgeworth Selection for qacA carriage in CC22, but not CC30, methicillin-resistant Staphylococcus aureus bloodstream infection isolates during a successful institutional infection control programme J Antimicrob Chemother 2013 68 992999

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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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