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Impact of Automatic Orders to Discontinue Vancomycin Therapy on Vancomycin Use in an Antimicrobial Stewardship Program

  • Denise M. Connor (a1), Shawn Binkley (a2), Neil O. Fishman (a1) (a3), Leanne B. Gasink (a1) (a4) (a3), Darren Linkin (a1) (a5) (a4) (a3) and Ebbing Lautenbach (a1) (a5) (a4) (a3)...

We examined the possible unintended consequences of a 72-hour automatic order to discontinue vancomycin therapy in an antimicrobial stewardship program (ASP). Of 120 patients, 11 had vancomycin therapy discontinued at 72 hours without a call to the ASP, and 7 experienced a treatment interruption of 6-36 hours. All discontinuation of therapy was considered appropriate, and the 7 treatment interruptions did not have clear clinical consequences. Only one-third of patients had ASP stickers that warned of impending discontinuation of vancomycin therapy placed appropriately in the medical record.

Corresponding author
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 825 Blockley Hall, 423 Guardian Dr., Philadelphia, PA 19104-6021 (
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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