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Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Published online by Cambridge University Press:  10 May 2016

Lisa Saiman*
Affiliation:
Department of Pediatrics, Columbia University Medical Center, New York, New York; and Department of Infection Prevention and Control, NewYork-Presbyterian Hospital, New York, New York Co-chairs of the Infection Prevention and Control Guideline for Cystic Fibrosis Committee
Jane D. Siegel
Affiliation:
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; and Children’s Medical Center, Dallas, Texas Co-chairs of the Infection Prevention and Control Guideline for Cystic Fibrosis Committee
John J. LiPuma
Affiliation:
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan; and Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan Co-chairs of the Infection Prevention and Control Guideline for Cystic Fibrosis Committee
Rebekah F. Brown
Affiliation:
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
Elizabeth A. Bryson
Affiliation:
Department of Pediatrics, Akron Children’s Hospital, Akron, Ohio
Mary Jo Chambers
Affiliation:
Department of Social Work, Arkansas Children’s Hospital, Little Rock, Arkansas
Veronica S. Downer
Affiliation:
University of Michigan Hospital, Ann Arbor, Michigan
Jill Fliege
Affiliation:
Pulmonary Division, Nebraska Medical Center, Omaha, Nebraska
Leslie A. Hazle
Affiliation:
Medical Department, Cystic Fibrosis Foundation, Bethesda, Maryland
Manu Jain
Affiliation:
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
Bruce C. Marshall
Affiliation:
Medical Department, Cystic Fibrosis Foundation, Bethesda, Maryland
Catherine O’Malley
Affiliation:
Department of Pediatrics, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois
Suzanne R. Pattee
Affiliation:
Adult with cystic fibrosis, Silver Spring, Maryland
Gail Potter-Bynoe
Affiliation:
Department of Infection Prevention and Control, Boston Children’s Hospital, Boston, Massachusetts
Siobhan Reid
Affiliation:
Parent
Karen A. Robinson
Affiliation:
Johns Hopkins University, Baltimore, Maryland
Kathryn A. Sabadosa
Affiliation:
Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire
H. Joel Schmidt
Affiliation:
Department of Pediatrics, Children’s Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia
Elizabeth Tullis
Affiliation:
Department of Medicine, University of Toronto, and Keenan Research Centre of Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Canada
Jennifer Webber
Affiliation:
Parent
David J. Weber
Affiliation:
Departments of Medicine and Pediatrics, University of North Carolina at Chapel Hill Medical School, Chapel Hill, North Carolina The list of authors represents the entire Infection Prevention and Control Guideline for Cystic Fibrosis Committee
*
Columbia University, 622 West 168th Street, PH4 West Room 470, New York, NY 10032 (ls5@cumc.columbia.edu).
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The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:

1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.

2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

Type
Research Article
Creative Commons
Creative Common License - CCCreative Common License - BY
© Lisa Saiman, Jane D. Siegel, John J. LiPuma, Rebekah F. Brown, Elizabeth A. Bryson, Mary Jo Chambers, Veronica S. Downer, Jill Fliege, Leslie A. Hazle, Manu Jain, Bruce C. Marshall, Catherine O'Malley, Suzanne R. Pattee, Gail Potter-Bynoe, Siobhan Reid, Karen A. Robinson, Kathryn A. Sabadosa, H. Joel Schmidt, Elizabeth Tullis, Jennifer Webber and David J. Weber 2014 This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
© 2014 by The Society for Healthcare Epidemiology of America and The Cystic Fibrosis Foundation.

References

1. Saiman, L, Siegel, J. Infection control recommendations for patients with cystic fibrosis: microbiology, important pathogens, and infection control practices to prevent patient-to-patient transmission. Infect Control Hosp Epidemiol 2003;24:S6S52.CrossRefGoogle ScholarPubMed
2. Sehulster, L, Chinn, RY. Guidelines for environmental infection control in health-care facilities: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC). MMWR Recomm Rep 2003;52:142.Google Scholar
3. Tablan, OC, Anderson, LJ, Besser, R, Bridges, C, Hajjeh, R. Guidelines for preventing health-care–associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep 2004;53:136.Google ScholarPubMed
4. Jensen, PA, Lambert, LA, Iademarco, MF, Ridzon, R. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005. MMWR Recomm Rep 2005;54:1141.Google Scholar
5. Siegel, JD, Rhinehart, E, Jackson, M, Chiarello, L. Management of multidrug-resistant organisms in health care settings, 2006. Am J Infect Control 2007;35:S165S193.CrossRefGoogle ScholarPubMed
6. Siegel, JD, Rhinehart, E, Jackson, M, Chiarello, L. 2007 Guideline for isolation precautions: preventing transmission of infectious agents in health care settings. Am J Infect Control 2007;35:S65S164.CrossRefGoogle ScholarPubMed
7. Rutala, WA, Weber, DJ; Healthcare Infection Control Practices Advisory Committee (HICPAC). Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008. http://www.cdc.gov/hicpac/pdf/guidelines/disinfection_nov_2008.pdf. Published 2008. Accessed January 2014.Google Scholar
8. Calfee, DP, Salgado, CD, Classen, D, et al. Strategies to prevent transmission of methicillin-resistant Staphylococcus aureus in acute care hospitals. Infect Control Hosp Epidemiol 2008;29(suppl 1):S62S80.Google Scholar
9. World Health Organization. Guidelines on Hand Hygiene in Healthcare. http://whqlibdoc.who.int/publications/2009/9789241597906_eng.pdf. Published 2009. Accessed January 13, 2014.Google Scholar
10. Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention. Infection Prevention Checklist for Outpatient Settings: Minimum Expectations for Safe Care. http://www.cdc.gov/HAI/pdfs/guidelines/ambulatory-care-checklist-07-2011.pdf. Published 2011. Accessed January 2014.Google Scholar
11. Advisory Committee on Immunization Practices; Centers for Disease Control and Prevention. Immunization of health-care personnel: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2011;60:145.Google Scholar
12. Guzman-Cottrill, JA, Ravin, KA, Bryant, KA, Zerr, DM, Kociolek, L, Siegel, JD. Infection prevention and control in residential facilities for pediatric patients and their families. Infect Control Hosp Epidemiol 2013;34:10031041.CrossRefGoogle ScholarPubMed
13. Rubin, LG, Levin, MJ, Ljungman, P, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis 2014;58:309318.Google Scholar
14. Centers for Disease Control and Prevention. Seasonal Influenza (Flu). http://www.cdc.gov/flu/. Published 2014. Accessed January 13, 2014.Google Scholar
15. Glatman-Freedman, A, Portelli, I, Jacobs, SK, et al. Attack rates assessment of the 2009 pandemic H1N1 influenza A in children and their contacts: a systematic review and meta-analysis. PLoS ONE 2012;7:e50228.Google Scholar
16. Dantes, R, Mu, Y, Belflower, R, et al. National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011. JAMA Intern Med 2013;173:19701978.Google Scholar
17. Iwamoto, M, Mu, Y, Lynfield, R, et al. Trends in invasive methicillin-resistant Staphylococcus aureus infections. Pediatrics 2013;132:e817e824.Google Scholar
18. Sievert, DM, Ricks, P, Edwards, JR, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010. Infect Control Hosp Epidemiol 2013;34:114.CrossRefGoogle Scholar
19. Savard, P, Perl, TM. A call for action: managing the emergence of multidrug-resistant Enterobacteriaceae in the acute care settings. Curr Opin Infect Dis 2012;25:371377.CrossRefGoogle Scholar
20. Coia, JE, Duckworth, GJ, Edwards, DI, et al. Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities. J Hosp Infect 2006;63(suppl 1):S1S44.CrossRefGoogle ScholarPubMed
21. Cystic Fibrosis Foundation. National Patient Registry 2012 Annual Data Report. Bethesda, MD: Cystic Fibrosis Foundation, 2013.Google Scholar
22. Dasenbrook, EC, Merlo, CA, Diener-West, M, Lechtzin, N, Boyle, MP. Persistent methicillin-resistant Staphylococcus aureus and rate of FEV1 decline in cystic fibrosis. Am J Respir Crit Care Med 2008;178:814821.Google Scholar
23. Dasenbrook, EC, Checkley, W, Merlo, CA, Konstan, MW, Lechtzin, N, Boyle, MP. Association between respiratory tract methicillin-resistant Staphylococcus aureus and survival in cystic fibrosis. JAMA 2010;303:23862392.Google Scholar
24. Leung, JM, Olivier, KN. Nontuberculous mycobacteria in patients with cystic fibrosis. Semin Respir Crit Care Med 2013;34:124134.Google ScholarPubMed
25. Kalish, LA, Waltz, DA, Dovey, M, et al. Impact of Burkholderia dolosa on lung function and survival in cystic fibrosis. Am J Respir Crit Care Med 2006;173:421425.Google Scholar
26. Lipuma, JJ. The changing microbial epidemiology in cystic fibrosis. Clin Microbiol Rev 2010;23:299323.CrossRefGoogle ScholarPubMed
27. Fothergill, JL, Walshaw, MJ, Winstanley, C. Transmissible strains of Pseudomonas aeruginosa in cystic fibrosis lung infections. Eur Respir J 2012;40:227238.Google Scholar
28. Aaron, SD, Vandemheen, KL, Ramotar, K, et al. Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis. JAMA 2010;304:21452153.Google Scholar
29. Waters, V, Zlosnik, JE, Yau, YC, Speert, DP, Aaron, SD, Guttman, DS. Comparison of three typing methods for Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Eur J Clin Microbiol Infect Dis 2012;31:33413350.Google Scholar
30. Luna, RA, Millecker, LA, Webb, CR, et al. Molecular epidemiological surveillance of multidrug-resistant Pseudomonas aeruginosa isolates in a pediatric population of patients with cystic fibrosis and determination of risk factors for infection with the Houston-1 strain. J Clin Microbiol 2013;51:12371240.Google Scholar
31. Elborn, JS. Fixing cystic fibrosis CFTR with correctors and potentiators: off to a good start. Thorax 2012;67:45.Google Scholar
32. Robinson, KA, Saldanha, IJ, McKoy, NA. Development of a framework to identify research gaps from systematic reviews. J Clin Epidemiol 2011;64:13251330.Google Scholar
33. Petitti, DB, Teutsch, SM, Barton, MB, Sawaya, GF, Ockene, JK, DeWitt, T. Update on the methods of the U.S. Preventive Services Task Force: insufficient evidence. Ann Intern Med 2009;150:199205.CrossRefGoogle ScholarPubMed
34. Sawaya, GF, Guirguis-Blake, J, LeFevre, M, Harris, R, Petitti, D. Update on the methods of the U.S. Preventive Services Task Force: estimating certainty and magnitude of net benefit. Ann Intern Med 2007;147:871875.CrossRefGoogle ScholarPubMed
35. Guyatt, GH, Oxman, AD, Vist, GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008;336:924926.Google Scholar
36. Ahmed, F, Temte, JL, Campos-Outcalt, D, Schunemann, HJ. Methods for developing evidence-based recommendations by the Advisory Committee on Immunization Practices (ACIP) of the U.S. Centers for Disease Control and Prevention (CDC). Vaccine 2011;29:91719176.CrossRefGoogle ScholarPubMed
37. Umscheid, CA, Agarwal, RK, Brennan, PJ. Updating the guideline development methodology of the Healthcare Infection Control Practices Advisory Committee (HICPAC). Am J Infect Control 2010;38:264273.Google Scholar
38. Griffin, MR. Influenza vaccination of healthcare workers: making the grade for action. Clin Infect Dis 2014;58:5860.Google Scholar
39. Miller, MB, Gilligan, PH. Laboratory aspects of management of chronic pulmonary infections in patients with cystic fibrosis. J Clin Microbiol 2003;41:40094015.Google Scholar
40. UK Cystic Fibrosis Trust. Laboratory Standards for Processing Microbiological Samples from People with Cystic Fibrosis. https://www.cysticfibrosis.org.uk/media/82034/cd-laboratory-standards-sept10.pdf. Published 2010. Accessed January 13, 2014.Google Scholar
41. Zhou, J, Garber, E, Desai, M, Saiman, L. Compliance of clinical microbiology laboratories in the United States with current recommendations for processing respiratory tract specimens from patients with cystic fibrosis. J Clin Microbiol 2006;44:15471549.Google Scholar
42. Rosenfeld, M, Emerson, J, Accurso, F, et al. Diagnostic accuracy of oropharyngeal cultures in infants and young children with cystic fibrosis. Pediatr Pulmonol 1999;28:321328.3.0.CO;2-V>CrossRefGoogle Scholar
43. Al-Saleh, S, Dell, SD, Grasemann, H, et al. Sputum induction in routine clinical care of children with cystic fibrosis. J Pediatr 2010;157:1006.e1–1011.e1.Google Scholar
44. Razvi, S, Quittell, L, Sewall, A, Quinton, H, Marshall, B, Saiman, L. Respiratory microbiology of patients with cystic fibrosis in the United States, 1995 to 2005. Chest 2009;136:15541560.Google Scholar
45. Davidson, AG, Chilvers, MA, Lillquist, YP. Effects of a Pseudomonas aeruginosa eradication policy in a cystic fibrosis clinic. Curr Opin Pulm Med 2012;18:615621.CrossRefGoogle Scholar
46. Alby, K, Gilligan, PH, Miller, MB. Comparison of matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry platforms for the identification of gram-negative rods from patients with cystic fibrosis. J Clin Microbiol 2013;51:38523854.Google Scholar
47. Desai, AP, Stanley, T, Atuan, M, et al. Use of matrix assisted laser desorption ionisation–time of flight mass spectrometry in a paediatric clinical laboratory for identification of bacteria commonly isolated from cystic fibrosis patients. J Clin Pathol 2012;65:835838.Google Scholar
48. Fernandez-Olmos, A, Garcia-Castillo, M, Morosini, MI, Lamas, A, Maiz, L, Canton, R. MALDI-TOF MS improves routine identification of non-fermenting gram negative isolates from cystic fibrosis patients. J Cyst Fibros 2012;11:5962.Google Scholar
49. Hurley, MN, Ariff, AH, Bertenshaw, C, Bhatt, J, Smyth, AR. Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis. J Cyst Fibros 2012;11:288292.Google Scholar
50. Macdonald, D, Cuthbertson, L, Doherty, C, et al. Early Pseudomonas aeruginosa infection in individuals with cystic fibrosis: is susceptibility testing justified? J Antimicrob Chemother 2010;65:23732375.Google Scholar
51. Cheng, K, Smyth, RL, Govan, JR, et al. Spread of β-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic. Lancet 1996;348:639642.Google Scholar
52. Denton, M, Kerr, K, Mooney, L, et al. Transmission of colistin-resistant Pseudomonas aeruginosa between patients attending a pediatric cystic fibrosis center. Pediatr Pulmonol 2002;34:257261.Google Scholar
53. Jones, AM, Govan, JR, Doherty, CJ, et al. Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic. Lancet 2001;358:557558.CrossRefGoogle Scholar
54. Lynch, SV, Bruce, KD. The cystic fibrosis airway microbiome. Cold Spring Harb Perspect Med 2013;3:a009738.Google Scholar
55. Rabin, HR, Surette, MG. The cystic fibrosis airway microbiome. Curr Opin Pulm Med 2012;18:622627.Google Scholar
56. Zemanick, ET, Sagel, SD, Harris, JK. The airway microbiome in cystic fibrosis and implications for treatment. Curr Opin Pediatr 2011;23:319324.Google Scholar
57. Zhao, J, Schloss, PD, Kalikin, LM, et al. Decade-long bacterial community dynamics in cystic fibrosis airways. Proc Natl Acad Sci USA 2012;109:58095814.CrossRefGoogle ScholarPubMed
58. Lipuma, JJ. Molecular tools for epidemiologic study of infectious diseases. Pediatr Infect Dis J 1998;17:667675.Google Scholar
59. Morel, AS, Saiman, L. The role of molecular epidemiologic typing in pediatric infection control. Semin Pediatr Infect Dis 2001;12:100106.Google Scholar
60. Tenover, FC, Arbeit, RD, Goering, RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:22332239.Google Scholar
61. Mahenthiralingam, E, Campbell, ME, Foster, J, Lam, JS, Speert, DP. Random amplified polymorphic DNA typing of Pseudomonas aeruginosa isolates recovered from patients with cystic fibrosis. J Clin Microbiol 1996;34:11291135.Google Scholar
62. van Belkum, A, Sluijuter, M, de Groot, R, Verbrugh, H, Hermans, PW. Novel BOX repeat PCR assay for high-resolution typing of Streptococcus pneumoniae strains. J Clin Microbiol 1996;34:11761179.CrossRefGoogle ScholarPubMed
63. Urwin, R, Maiden, MC. Multi-locus sequence typing: a tool for global epidemiology. Trends Microbiol 2003;11:479487.Google Scholar
64. Multi Locus Sequence Typing website. http://www.mlst.net. Published 2014. Accessed January 14, 2014.Google Scholar
65. Snitkin, ES, Zelazny, AM, Thomas, PJ, et al. Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing. Sci Transl Med 2012;4:148ra116.Google Scholar
66. Bryant, JM, Grogono, DM, Greaves, D, et al. Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study. Lancet 2013;381:15511560.Google Scholar
67. International Burkholderia cepacia Working Group website. http://users.ugent.be/∼tcoenye/index_bestanden/index.htm. Published 2010. Accessed January 13, 2014.Google Scholar
68. Cystic Fibrosis Foundation. National Patient Registry 2012 Annual Data Report to the Center Directors. Bethesda, MD: Cystic Fibrosis Foundation, 2013.Google Scholar
69. Burkholder, W. Sour skin: a bacterial rot of onion bulbs. Phytopathology 1950;40:115117.Google Scholar
70. Coenye, T, Mahenthiralingam, E, Henry, D, et al. Burkholderia ambifaria sp. nov., a novel member of the Burkholderia cepacia complex including biocontrol and cystic fibrosis–related isolates. Int J Syst Evol Microbiol 2001;51:14811490.Google Scholar
71. Vandamme, P, Henry, D, Coenye, T, et al. Burkholderia anthina sp. nov. and Burkholderia pyrrocinia, two additional Burkholderia cepacia complex bacteria, may confound results of new molecular diagnostic tools. FEMS Immunol Med Microbiol 2002;33:143149.Google Scholar
72. Vanlaere, E, Baldwin, A, Gevers, D, et al. Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov. Int J Syst Evol Microbiol 2009;59:102111.CrossRefGoogle Scholar
73. Vandamme, P, Holmes, B, Coenye, T, et al. Burkholderia cenocepacia sp. nov.—a new twist to an old story. Res Microbiol 2003;154:9196.Google Scholar
74. Vandamme, P, Holmes, B, Vancanneyt, M, et al. Occurrence of multiple genomovars of Burkholderia cepacia in cystic fibrosis patients and proposal of Burkholderia multivorans sp. nov. Int J Syst Bacteriol 1997;47:11881200.Google Scholar
75. Vandamme, P, Mahenthiralingam, E, Holmes, B, et al. Identification and population structure of Burkholderia stabilis sp. nov. (formerly Burkholderia cepacia genomovar IV). J Clin Microbiol 2000;38:10421047.Google Scholar
76. Vanlaere, E, Lipuma, JJ, Baldwin, A, et al. Burkholderia latens sp. nov., Burkholderia diffusa sp. nov., Burkholderia arboris sp. nov., Burkholderia seminalis sp. nov. and Burkholderia metallica sp. nov., novel species within the Burkholderia cepacia complex. Int J Syst Evol Microbiol 2008;58:15801590.Google Scholar
77. Yabuuchi, E, Kawamura, Y, Ezaki, T, et al. Burkholderia uboniae sp. nov., L-arabinose-assimilating but different from Burkholderia thailandensis and Burkholderia vietnamiensis . Microbiol Immunol 2000;44:307317.Google Scholar
78. Peeters, C, Zlosnik, JE, Spilker, T, Hird, TJ, Lipuma, JJ, Vandamme, P. Burkholderia pseudomultivorans sp. nov., a novel Burkholderia cepacia complex species from human respiratory samples and the rhizosphere. Syst Appl Microbiol 2013;36:483489.Google Scholar
79. Vermis, K, Coenye, T, LiPuma, JJ, Mahenthiralingam, E, Nelis, HJ, Vandamme, P. Proposal to accommodate Burkholderia cepacia genomovar VI as Burkholderia dolosa sp. nov. Int J Syst Evol Microbiol 2004;54:689691.Google Scholar
80. Gillis, M, Tran Van, V, Bardin, R, et al. Polyphasic taxonomy in the genus Burkholderia leading to an emended description of the genus and proposition of Burkholderia vietnamiensis sp. nov. for N2-fixing isolates from rice in Vietnam. Int J Syst Bacteriol 1995;45:274.Google Scholar
81. Lipuma, JJ. Update on the Burkholderia cepacia complex. Curr Opin Pulm Med 2005;11:528533.Google Scholar
82. Whitby, PW, Pope, LC, Carter, KB, LiPuma, JJ, Stull, TL. Species-specific PCR as a tool for the identification of Burkholderia gladioli . J Clin Microbiol 2000;38:282285.CrossRefGoogle ScholarPubMed
83. Ciofu, O, Hansen, CR, Hoiby, N. Respiratory bacterial infections in cystic fibrosis. Curr Opin Pulm Med 2013;19:251258.Google Scholar
84. Prunier, AL, Malbruny, B, Laurans, M, Brouard, J, Duhamel, JF, Leclercq, R. High rate of macrolide resistance in Staphylococcus aureus strains from patients with cystic fibrosis reveals high proportions of hypermutable strains. J Infect Dis 2003;187:17091716.Google Scholar
85. Besier, S, Zander, J, Kahl, BC, Kraiczy, P, Brade, V, Wichelhaus, TA. The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. Antimicrob Agents Chemother 2008;52:21832189.CrossRefGoogle ScholarPubMed
86. Proctor, RA, von Eiff, C, Kahl, BC, et al. Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections. Nat Rev Microbiol 2006;4:295305.CrossRefGoogle ScholarPubMed
87. Proctor, RA, Kahl, B, von Eiff, C, Vaudaux, PE, Lew, DP, Peters, G. Staphylococcal small colony variants have novel mechanisms for antibiotic resistance. Clin Infect Dis 1998;27(suppl 1):S68S74.Google Scholar
88. Sadowska, B, Bonar, A, von Eiff, C, et al. Characteristics of Staphylococcus aureus, isolated from airways of cystic fibrosis patients, and their small colony variants. FEMS Immunol Med Microbiol 2002;32:191197.Google Scholar
89. Mitchell, G, Grondin, G, Bilodeau, G, Cantin, AM, Malouin, F. Infection of polarized airway epithelial cells by normal and small-colony variant strains of Staphylococcus aureus is increased in cells with abnormal cystic fibrosis transmembrane conductance regulator function and is influenced by NF-κB. Infect Immun 2011;79:35413551.Google Scholar
90. Proctor, RA, van Langevelde, P, Kristjansson, M, Maslow, JN, Arbeit, RD. Persistent and relapsing infections associated with small-colony variants of Staphylococcus aureus . Clin Infect Dis 1995;20:95102.Google Scholar
91. Kahl, BC, Duebbers, A, Lubritz, G, et al. Population dynamics of persistent Staphylococcus aureus isolated from the airways of cystic fibrosis patients during a 6-year prospective study. J Clin Microbiol 2003;41:44244427.Google Scholar
92. Besier, S, Smaczny, C, von Mallinckrodt, C, et al. Prevalence and clinical significance of Staphylococcus aureus small-colony variants in cystic fibrosis lung disease. J Clin Microbiol 2007;45:168172.CrossRefGoogle ScholarPubMed
93. Schneider, M, Muhlemann, K, Droz, S, Couzinet, S, Casaulta, C, Zimmerli, S. Clinical characteristics associated with isolation of small-colony variants of Staphylococcus aureus and Pseudomonas aeruginosa from respiratory secretions of patients with cystic fibrosis. J Clin Microbiol 2008;46:18321834.Google Scholar
94. Hoffman, LR, Deziel, E, D’Argenio, DA, et al. Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa . Proc Natl Acad Sci USA 2006;103:19890–19895.Google Scholar
95. Wolter, DJ, Emerson, JC, McNamara, S, et al. Staphylococcus aureus small-colony variants are independently associated with worse lung disease in children with cystic fibrosis. Clin Infect Dis 2013;57:384391.Google Scholar
96. Kirisits, MJ, Prost, L, Starkey, M, Parsek, MR. Characterization of colony morphology variants isolated from Pseudomonas aeruginosa biofilms. Appl Environ Microbiol 2005;71:48094821.Google Scholar
97. Anderson, SW, Stapp, JR, Burns, JL, Qin, X. Characterization of small-colony-variant Stenotrophomonas maltophilia isolated from the sputum specimens of five patients with cystic fibrosis. J Clin Microbiol 2007;45:529535.CrossRefGoogle ScholarPubMed
98. Haussler, S, Lehmann, C, Breselge, C, et al. Fatal outcome of lung transplantation in cystic fibrosis patients due to small-colony variants of the Burkholderia cepacia complex. Eur J Clin Microbiol Infect Dis 2003;22:249253.Google Scholar
99. Kasperbauer, SH, Daley, CL. Diagnosis and treatment of infections due to Mycobacterium avium complex. Semin Respir Crit Care Med 2008;29:569576.CrossRefGoogle ScholarPubMed
100. Adekambi, T, Berger, P, Raoult, D, Drancourt, M. rpoB gene sequence–based characterization of emerging nontuberculous mycobacteria with descriptions of Mycobacterium bolletii sp. nov., Mycobacterium phocaicum sp. nov. and Mycobacterium aubagnense sp. nov. Int J Syst Evol Microbiol 2006;56:133143.Google Scholar
101. Adekambi, T, Reynaud-Gaubert, M, Greub, G, et al. Amoebal coculture of “Mycobacterium massiliense” sp. nov. from the sputum of a patient with hemoptoic pneumonia. J Clin Microbiol 2004;42:54935501.Google Scholar
102. Olivier, KN, Weber, DJ, Wallace, RJ Jr, et al. Nontuberculous mycobacteria. I. Multicenter prevalence study in cystic fibrosis. Am J Respir Crit Care Med 2003;167:828834.Google Scholar
103. Levy, I, Grisaru-Soen, G, Lerner-Geva, L, et al. Multicenter cross-sectional study of nontuberculous mycobacterial infections among cystic fibrosis patients, Israel. Emerg Infect Dis 2008;14:378384.Google Scholar
104. Roux, AL, Catherinot, E, Ripoll, F, et al. Multicenter study of prevalence of nontuberculous mycobacteria in patients with cystic fibrosis in France. J Clin Microbiol 2009;47:41244128.Google Scholar
105. Pihet, M, Carrere, J, Cimon, B, et al. Occurrence and relevance of filamentous fungi in respiratory secretions of patients with cystic fibrosis—a review. Med Mycol 2009;47:387397.Google Scholar
106. Bains, SN, Judson, MA. Allergic bronchopulmonary aspergillosis. Clin Chest Med 2012;33:265281.Google Scholar
107. Knutsen, AP, Slavin, RG. Allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis. Clin Dev Immunol 2011;2011:843763.Google Scholar
108. Kousha, M, Tadi, R, Soubani, AO. Pulmonary aspergillosis: a clinical review. Eur Respir Rev 2011;20:156174.CrossRefGoogle ScholarPubMed
109. Moss, RB. Allergic bronchopulmonary aspergillosis and Aspergillus infection in cystic fibrosis. Curr Opin Pulm Med 2010;16:598603.Google Scholar
110. Liu, JC, Modha, DE, Gaillard, EA. What is the clinical significance of filamentous fungi positive sputum cultures in patients with cystic fibrosis? J Cyst Fibros 2013;12:187193.CrossRefGoogle ScholarPubMed
111. Braun, AT, Merlo, CA. Cystic fibrosis lung transplantation. Curr Opin Pulm Med 2011;17:467472.Google Scholar
112. Hota, B. Contamination, disinfection, and cross-colonization: are hospital surfaces reservoirs for nosocomial infection? Clin Infect Dis 2004;39:11821189.Google Scholar
113. Dowell, SF, Simmerman, JM, Erdman, DD, et al. Severe acute respiratory syndrome coronavirus on hospital surfaces. Clin Infect Dis 2004;39:652657.CrossRefGoogle ScholarPubMed
114. Bischoff, WE, Swett, K, Leng, I, Peters, TR. Exposure to influenza virus aerosols during routine patient care. J Infect Dis 2013;207:10371046.Google Scholar
115. Advisory Committee on Immunization Practices. Prevention and control of influenza with vaccines: interim recommendations of the Advisory Committee on Immunization Practices (ACIP), 2013. MMWR Morb Mortal Wkly Rep 2013;62:356.Google Scholar
116. Tran, K, Cimon, K, Severn, M, Pessoa-Silva, CL, Conly, J. Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review. PLoS ONE 2012;7:e35797.Google Scholar
117. Roy, CJ, Milton, DK. Airborne transmission of communicable infection—the elusive pathway. N Engl J Med 2004;350:17101712.Google Scholar
118. Wong, TW, Lee, CK, Tam, W, et al. Cluster of SARS among medical students exposed to single patient, Hong Kong. Emerg Infect Dis 2004;10:269276.Google Scholar
119. Clifton, IJ, Fletcher, LA, Beggs, CB, Denton, M, Conway, SP, Peckham, DG. An aerobiological model of aerosol survival of different strains of Pseudomonas aeruginosa isolated from people with cystic fibrosis. J Cyst Fibros 2010;9:6468.Google Scholar
120. Festini, F, Taccetti, G, Galici, V, et al. A 1-m distance is not safe for children with cystic fibrosis at risk for cross-infection with Pseudomonas aeruginosa . Am J Infect Control 2010;38:244245.CrossRefGoogle Scholar
121. Wainwright, CE, France, MW, O’Rourke, P, et al. Cough-generated aerosols of Pseudomonas aeruginosa and other gram-negative bacteria from patients with cystic fibrosis. Thorax 2009;64:926931.Google Scholar
122. Clifton, IJ, Peckham, DG. Defining routes of airborne transmission of Pseudomonas aeruginosa in people with cystic fibrosis. Expert Rev Respir Med 2010;4:519529.Google Scholar
123. Spicknall, IH, Koopman, JS, Nicas, M, Pujol, JM, Li, S, Eisenberg, JN. Informing optimal environmental influenza interventions: how the host, agent, and environment alter dominant routes of transmission. PLoS Comput Biol 2010;6:e1000969.CrossRefGoogle ScholarPubMed
124. Brankston, G, Gitterman, L, Hirji, Z, Lemieux, C, Gardam, M. Transmission of influenza A in human beings. Lancet Infect Dis 2007;7:257265.Google Scholar
125. Zuckerman, JB, Prato, BS, Clock, S, et al. Characterizing bacterial air contamination during CF outpatient visits. Pediatr Pulmonol 2012;47(suppl 35):326.Google Scholar
126. Ferroni, A, Werkhauser-Bertrand, A, Le Bourgeois, M, et al. Bacterial contamination in the environment of hospitalised children with cystic fibrosis. J Cyst Fibros 2008;7:477482.Google Scholar
127. Panagea, S, Winstanley, C, Walshaw, MJ, Ledson, MJ, Hart, CA. Environmental contamination with an epidemic strain of Pseudomonas aeruginosa in a Liverpool cystic fibrosis centre, and study of its survival on dry surfaces. J Hosp Infect 2005;59:102107.Google Scholar
128. Zuckerman, JB, Zuaro, DE, Prato, BS, et al. Bacterial contamination of cystic fibrosis clinics. J Cyst Fibros 2009;8:186192.Google Scholar
129. Aitken, ML, Limaye, A, Pottinger, P, et al. Respiratory outbreak of Mycobacterium abscessus subspecies massiliense in a lung transplant and cystic fibrosis center. Am J Respir Crit Care Med 2012;185:231232.Google Scholar
130. Speert, DP, Campbell, ME, Henry, DA, et al. Epidemiology of Pseudomonas aeruginosa in cystic fibrosis in British Columbia, Canada. Am J Respir Crit Care Med 2002;166:988993.Google Scholar
131. Jelsbak, L, Johansen, HK, Frost, AL, et al. Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients. Infect Immun 2007;75:22142224.Google Scholar
132. Spilker, T, LiPuma, JJ. Genotype analysis of Pseudomonas aeruginosa isolates from U.S. CF centers. Pediatr Pulmonol 2013;48(suppl 36):306.Google Scholar
133. Biddick, R, Spilker, T, Martin, A, LiPuma, JJ. Evidence of transmission of Burkholderia cepacia, Burkholderia multivorans and Burkholderia dolosa among persons with cystic fibrosis. FEMS Microbiol Lett 2003;228:5762.Google Scholar
134. LiPuma, JJ, Dasen, SE, Nielson, DW, Stern, RC, Stull, TL. Person-to-person transmission of Pseudomonas cepacia between patients with cystic fibrosis. Lancet 1990;336:10941096.Google Scholar
135. Govan, JR, Brown, PH, Maddison, J, et al. Evidence for transmission of Pseudomonas cepacia by social contact in cystic fibrosis. Lancet 1993;342:1519.Google Scholar
136. Schlichting, C, Branger, C, Fournier, JM, et al. Typing of Staphylococcus aureus by pulsed-field gel electrophoresis, zymotyping, capsular typing, and phage typing: resolution of clonal relationships. J Clin Microbiol 1993;31:227232.Google Scholar
137. Elizur, A, Orscheln, RC, Ferkol, TW, Dunne, WM Jr, Storch, GA, Cannon, CL. Transmission of Panton-Valentine leukocidin–positive Staphylococcus aureus between patients with cystic fibrosis. J Pediatr 2007;151:9092.Google Scholar
138. Givney, R, Vickery, A, Holliday, A, Pegler, M, Benn, R. Methicillin-resistant Staphylococcus aureus in a cystic fibrosis unit. J Hosp Infect 1997;35:2736.Google Scholar
139. Cocchi, P, Cariani, L, Favari, F, et al. Molecular epidemiology of meticillin-resistant Staphylococcus aureus in Italian cystic fibrosis patients: a national overview. J Cyst Fibros 2011;10:407411.Google Scholar
140. Denton, M, Todd, NJ, Kerr, KG, Hawkey, PM, Littlewood, JM. Molecular epidemiology of Stenotrophomonas maltophilia isolated from clinical specimens from patients with cystic fibrosis and associated environmental samples. J Clin Microbiol 1998;36:19531958.CrossRefGoogle ScholarPubMed
141. Marzuillo, C, De Giusti, M, Tufi, D, et al. Molecular characterization of Stenotrophomonas maltophilia isolates from cystic fibrosis patients and the hospital environment. Infect Control Hosp Epidemiol 2009;30:753758.Google Scholar
142. McPhail, GL, VanDyke, R, Renchel, M, LiPuma, JJ, Joseph, PM. An update on clinical outcomes associated with a clonal strain of Achromobacter (Alcaligenes) xylosoxidans . Pediatr Pulmonol 2009;44(suppl 32):310.Google Scholar
143. Krzewinski, JW, Nguyen, CD, Foster, JM, Burns, JL. Use of random amplified polymorphic DNA PCR to examine epidemiology of Stenotrophomonas maltophilia and Achromobacter (Alcaligenes) xylosoxidans from patients with cystic fibrosis. J Clin Microbiol 2001;39:35973602.Google Scholar
144. Van Daele, S, Verhelst, R, Claeys, G, et al. Shared genotypes of Achromobacter xylosoxidans strains isolated from patients at a cystic fibrosis rehabilitation center. J Clin Microbiol 2005;43:29983002.Google Scholar
145. Harris, KA, Kenna, DT, Blauwendraat, C, et al. Molecular fingerprinting of Mycobacterium abscessus strains in a cohort of pediatric cystic fibrosis patients. J Clin Microbiol 2012;50:17581761.Google Scholar
146. Baldwin, A, Mahenthiralingam, E, Thickett, KM, et al. Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex. J Clin Microbiol 2005;43:46654673.Google Scholar
147. Coenye, T, LiPuma, JJ. Multilocus restriction typing: a novel tool for studying global epidemiology of Burkholderia cepacia complex infection in cystic fibrosis. J Infect Dis 2002;185:14541462.Google Scholar
148. Dasen, SE, LiPuma, JJ, Kostman, JR, Stull, TL. Characterization of PCR-ribotyping for Burkholderia (Pseudomonas) cepacia . J Clin Microbiol 1994;32:24222424.Google Scholar
149. LiPuma, JJ, Mortensen, JE, Dasen, SE, et al. Ribotype analysis of Pseudomonas cepacia from cystic fibrosis treatment centers. J Pediatr 1988;113:859862.Google Scholar
150. Spilker, T, Baldwin, A, Bumford, A, Dowson, CG, Mahenthiralingam, E, LiPuma, JJ. Expanded multilocus sequence typing for Burkholderia species. J Clin Microbiol 2009;47:26072610.Google Scholar
151. Pegues, DA, Carson, LA, Tablan, OC, et al; Summer Camp Study Group. Acquisition of Pseudomonas cepacia at summer camps for patients with cystic fibrosis. J Pediatr 1994;124:694702.Google Scholar
152. Johnson, WM, Tyler, SD, Rozee, KR. Linkage analysis of geographic and clinical clusters in Pseudomonas cepacia infections by multilocus enzyme electrophoresis and ribotyping. J Clin Microbiol 1994;32:924930.Google Scholar
153. Pitt, TL, Kaufmann, ME, Patel, PS, Benge, LC, Gaskin, S, Livermore, DM. Type characterisation and antibiotic susceptibility of Burkholderia (Pseudomonas) cepacia isolates from patients with cystic fibrosis in the United Kingdom and the Republic of Ireland. J Med Microbiol 1996;44:203210.Google Scholar
154. Chen, JS, Witzmann, KA, Spilker, T, Fink, RJ, LiPuma, JJ. Endemicity and inter-city spread of Burkholderia cepacia genomovar III in cystic fibrosis. J Pediatr 2001;139:643649.Google Scholar
155. Coenye, T, LiPuma, JJ. Population structure analysis of Burkholderia cepacia genomovar III: varying degrees of genetic recombination characterize major clonal complexes. Microbiology 2003;149:7788.Google Scholar
156. Kumar, A, Dietrich, S, Schneider, W, et al. Genetic relatedness of Burkholderia (Pseudomonas) cepacia isolates from five cystic fibrosis centers in Michigan. Respir Med 1997;91:485492.Google Scholar
157. Springman, AC, Jacobs, JL, Somvanshi, VS, et al. Genetic diversity and multihost pathogenicity of clinical and environmental strains of Burkholderia cenocepacia . Appl Environ Microbiol 2009;75:52505260.CrossRefGoogle ScholarPubMed
158. Drevinek, P, Vosahlikova, S, Cinek, O, et al. Widespread clone of Burkholderia cenocepacia in cystic fibrosis patients in the Czech Republic. J Med Microbiol 2005;54:655659.Google Scholar
159. Mahenthiralingam, E, Vandamme, P, Campbell, ME, et al. Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: virulent transmissible strains of genomovar III can replace Burkholderia multivorans . Clin Infect Dis 2001;33:14691475.Google Scholar
160. Speert, DP, Henry, D, Vandamme, P, Corey, M, Mahenthiralingam, E. Epidemiology of Burkholderia cepacia complex in patients with cystic fibrosis, Canada. Emerg Infect Dis 2002;8:181187.Google Scholar
161. Campana, S, Taccetti, G, Ravenni, N, et al. Transmission of Burkholderia cepacia complex: evidence for new epidemic clones infecting cystic fibrosis patients in Italy. J Clin Microbiol 2005;43:51365142.Google Scholar
162. Manno, G, Dalmastri, C, Tabacchioni, S, et al. Epidemiology and clinical course of Burkholderia cepacia complex infections, particularly those caused by different Burkholderia cenocepacia strains, among patients attending an Italian cystic fibrosis center. J Clin Microbiol 2004;42:14911497.Google Scholar
163. Drevinek, P, Cinek, O, Melter, J, Langsadl, L, Navesnakova, Y, Vavrova, V. Genomovar distribution of the Burkholderia cepacia complex differs significantly between Czech and Slovak patients with cystic fibrosis. J Med Microbiol 2003;52:603604.Google Scholar
164. Segonds, C, Heulin, T, Marty, N, Chabanon, G. Differentiation of Burkholderia species by PCR–restriction fragment length polymorphism analysis of the 16S rRNA gene and application to cystic fibrosis isolates. J Clin Microbiol 1999;37:22012208.Google Scholar
165. Whiteford, ML, Wilkinson, JD, McColl, JH, et al. Outcome of Burkholderia (Pseudomonas) cepacia colonisation in children with cystic fibrosis following a hospital outbreak. Thorax 1995;50:11941198.CrossRefGoogle ScholarPubMed
166. Govan, JR, Brown, AR, Jones, AM. Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection. Future Microbiol 2007;2:153164.Google Scholar
167. Mortensen, JE, Fisher, MC, LiPuma, JJ. Recovery of Pseudomonas cepacia and other Pseudomonas species from the environment. Infect Control Hosp Epidemiol 1995;16:3032.Google Scholar
168. Johansen, HK, Kovesi, TA, Koch, C, Corey, M, Hoiby, N, Levison, H. Pseudomonas aeruginosa and Burkholderia cepacia infection in cystic fibrosis patients treated in Toronto and Copenhagen. Pediatr Pulmonol 1998;26:8996.Google Scholar
169. Corey, M, Farewell, V. Determinants of mortality from cystic fibrosis in Canada, 1970–1989. Am J Epidemiol 1996;143:10071017.Google Scholar
170. Rosenfeld, M, Davis, R, FitzSimmons, S, Pepe, M, Ramsey, B. Gender gap in cystic fibrosis mortality. Am J Epidemiol 1997;145:794803.Google Scholar
171. Murray, S, Charbeneau, J, Marshall, BC, LiPuma, JJ. Impact of Burkholderia infection on lung transplantation in cystic fibrosis. Am J Respir Crit Care Med 2008;178:363371.Google Scholar
172. De Soyza, A, Morris, K, McDowell, A, et al. Prevalence and clonality of Burkholderia cepacia complex genomovars in UK patients with cystic fibrosis referred for lung transplantation. Thorax 2004;59:526528.Google Scholar
173. Scott, FW, Pitt, TL. Identification and characterization of transmissible Pseudomonas aeruginosa strains in cystic fibrosis patients in England and Wales. J Med Microbiol 2004;53:609615.Google Scholar
174. Romling, U, Fiedler, B, Bosshammer, J, et al. Epidemiology of chronic Pseudomonas aeruginosa infections in cystic fibrosis. J Infect Dis 1994;170:16161621.Google Scholar
175. Tummler, B, Koopmann, U, Grothues, D, Weissbrodt, H, Steinkamp, G, von der Hardt, H. Nosocomial acquisition of Pseudomonas aeruginosa by cystic fibrosis patients. J Clin Microbiol 1991;29:12651267.Google Scholar
176. Wolz, C, Kiosz, G, Ogle, JW, et al. Pseudomonas aeruginosa cross-colonization and persistence in patients with cystic fibrosis: use of a DNA probe. Epidemiol Infect 1989;102:205214.Google Scholar
177. Grothues, D, Koopmann, U, von der Hardt, H, Tummler, B. Genome fingerprinting of Pseudomonas aeruginosa indicates colonization of cystic fibrosis siblings with closely related strains. J Clin Microbiol 1988;26:19731977.Google Scholar
178. Pedersen, SS, Koch, C, Hoiby, N, Rosendal, K. An epidemic spread of multiresistant Pseudomonas aeruginosa in a cystic fibrosis centre. J Antimicrob Chemother 1986;17:505516.Google Scholar
179. O’Carroll, MR, Syrmis, MW, Wainwright, CE, et al. Clonal strains of Pseudomonas aeruginosa in paediatric and adult cystic fibrosis units. Eur Respir J 2004;24:101106.CrossRefGoogle ScholarPubMed
180. Armstrong, D, Bell, S, Robinson, M, et al. Evidence for spread of a clonal strain of Pseudomonas aeruginosa among cystic fibrosis clinics. J Clin Microbiol 2003;41:22662267.Google Scholar
181. Armstrong, DS, Nixon, GM, Carzino, R, et al. Detection of a widespread clone of Pseudomonas aeruginosa in a pediatric cystic fibrosis clinic. Am J Respir Crit Care Med 2002;166:983987.Google Scholar
182. Syrmis, MW, O’Carroll, MR, Sloots, TP, et al. Rapid genotyping of Pseudomonas aeruginosa isolates harboured by adult and paediatric patients with cystic fibrosis using repetitive-element-based PCR assays. J Med Microbiol 2004;53:10891096.Google Scholar
183. Bradbury, R, Champion, A, Reid, DW. Poor clinical outcomes associated with a multi-drug resistant clonal strain of Pseudomonas aeruginosa in the Tasmanian cystic fibrosis population. Respirology 2008;13:886892.Google Scholar
184. van Mansfeld, R, Willems, R, Brimicombe, R, et al. Pseudomonas aeruginosa genotype prevalence in Dutch cystic fibrosis patients and age dependency of colonization by various P. aeruginosa sequence types. J Clin Microbiol 2009;47:40964101.Google Scholar
185. Griffiths, AL, Jamsen, K, Carlin, JB, et al. Effects of segregation on an epidemic Pseudomonas aeruginosa strain in a cystic fibrosis clinic. Am J Respir Crit Care Med 2005;171:10201025.Google Scholar
186. Ashish, A, Shaw, M, Winstanley, C, Ledson, MJ, Walshaw, MJ. Increasing resistance of the Liverpool epidemic strain (LES) of Pseudomonas aeruginosa (Psa) to antibiotics in cystic fibrosis (CF)—a cause for concern? J Cyst Fibros 2012;11:173179.Google Scholar
187. Al-Aloul, M, Crawley, J, Winstanley, C, Hart, CA, Ledson, MJ, Walshaw, MJ. Increased morbidity associated with chronic infection by an epidemic Pseudomonas aeruginosa strain in CF patients. Thorax 2004;59:334336.Google Scholar
188. Jones, AM, Dodd, ME, Doherty, CJ, Govan, JR, Webb, AK. Increased treatment requirements of patients with cystic fibrosis who harbour a highly transmissible strain of Pseudomonas aeruginosa . Thorax 2002;57:924925.Google Scholar
189. Ashish, A, Shaw, M, McShane, J, Ledson, MJ, Walshaw, MJ. Health-related quality of life in cystic fibrosis patients infected with transmissible Pseudomonas aeruginosa strains: cohort study. JRSM Short Rep 2012;3:12.Google Scholar
190. Spilker, T, Vandamme, P, Lipuma, JJ. Identification and distribution of Achromobacter species in cystic fibrosis. J Cyst Fibros 2013;12:298301.Google Scholar
191. Vu-Thien, H, Darbord, JC, Moissenet, D, et al. Investigation of an outbreak of wound infections due to Alcaligenes xylosoxidans transmitted by chlorhexidine in a burns unit. Eur J Clin Microbiol Infect Dis 1998;17:724726.Google Scholar
192. Weitkamp, JH, Tang, YW, Haas, DW, Midha, NK, Crowe, JE Jr. Recurrent Achromobacter xylosoxidans bacteremia associated with persistent lymph node infection in a patient with hyper-immunoglobulin M syndrome. Clin Infect Dis 2000;31:11831187.Google Scholar
193. Duggan, JM, Goldstein, SJ, Chenoweth, CE, Kauffman, CA, Bradley, SF. Achromobacter xylosoxidans bacteremia: report of four cases and review of the literature. Clin Infect Dis 1996;23:569576.Google Scholar
194. Dunne, WM Jr, Maisch, S. Epidemiological investigation of infections due to Alcaligenes species in children and patients with cystic fibrosis: use of repetitive-element-sequence polymerase chain reaction. Clin Infect Dis 1995;20:836841.Google Scholar
195. Vu-Thien, H, Moissenet, D, Valcin, M, Dulot, C, Tournier, G, Garbarg-Chenon, A. Molecular epidemiology of Burkholderia cepacia, Stenotrophomonas maltophilia, and Alcaligenes xylosoxidans in a cystic fibrosis center. Eur J Clin Microbiol Infect Dis 1996;15:876879.Google Scholar
196. Kanellopoulou, M, Pournaras, S, Iglezos, H, Skarmoutsou, N, Papafrangas, E, Maniatis, AN. Persistent colonization of nine cystic fibrosis patients with an Achromobacter (Alcaligenes) xylosoxidans clone. Eur J Clin Microbiol Infect Dis 2004;23:336339.Google Scholar
197. Coenye, T, Spilker, T, Reik, R, Vandamme, P, Lipuma, JJ. Use of PCR analyses to define the distribution of Ralstonia species recovered from patients with cystic fibrosis. J Clin Microbiol 2005;43:34633466.Google Scholar
198. Coenye, T, Vandamme, P, LiPuma, JJ. Infection by Ralstonia species in cystic fibrosis patients: identification of R. pickettii and R. mannitolilytica by polymerase chain reaction. Emerg Infect Dis 2002;8:692696.Google Scholar
199. Vandamme, P, Coenye, T. Taxonomy of the genus Cupriavidus: a tale of lost and found. Int J Syst Evol Microbiol 2004;54:22852289.Google Scholar
200. Vandamme, P, Goris, J, Coenye, T, et al. Assignment of Centers for Disease Control group IVc-2 to the genus Ralstonia as Ralstonia paucula sp. nov. Int J Syst Bacteriol 1999;49(pt 2):663669.Google Scholar
201. Coenye, T, Falsen, E, Vancanneyt, M, et al. Classification of Alcaligenes faecalis–like isolates from the environment and human clinical samples as Ralstonia gilardii sp. nov. Int J Syst Bacteriol 1999;49(pt 2):405413.Google Scholar
202. Coenye, T, Vandamme, P, LiPuma, JJ. Ralstonia respiraculi sp. nov., isolated from the respiratory tract of cystic fibrosis patients. Int J Syst Evol Microbiol 2003;53:13391342.Google Scholar
203. Chen, WM, Laevens, S, Lee, TM, et al. Ralstonia taiwanensis sp. nov., isolated from root nodules of Mimosa species and sputum of a cystic fibrosis patient. Int J Syst Evol Microbiol 2001;51:17291735.Google Scholar
204. LiPuma, JJ. Burkholderia and emerging pathogens in cystic fibrosis. Semin Respir Crit Care Med 2003;24:681692.Google Scholar
205. Coenye, T, Falsen, E, Hoste, B, et al. Description of Pandoraea gen. nov. with Pandoraea apista sp. nov., Pandoraea pulmonicola sp. nov., Pandoraea pnomenusa sp. nov., Pandoraea sputorum sp. nov. and Pandoraea norimbergensis comb. nov. Int J Syst Evol Microbiol 2000;50(pt 2):887899.Google Scholar
206. Jorgensen, IM, Johansen, HK, Frederiksen, B, et al. Epidemic spread of Pandoraea apista, a new pathogen causing severe lung disease in cystic fibrosis patients. Pediatr Pulmonol 2003;36:439446.Google Scholar
207. Gorwitz, RJ, Kruszon-Moran, D, McAllister, SK, et al. Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001–2004. J Infect Dis 2008;197:12261234.Google Scholar
208. Rosenfeld, M, Bernardo-Ocampo, C, Emerson, J, Genatossio, A, Burns, J, Gibson, R. Prevalence of cystic fibrosis pathogens in the oropharynx of healthy children and implications for cystic fibrosis care. J Cyst Fibros 2012;11:456457.Google Scholar
209. Goerke, C, Kraning, K, Stern, M, Doring, G, Botzenhart, K, Wolz, C. Molecular epidemiology of community-acquired Staphylococcus aureus in families with and without cystic fibrosis patients. J Infect Dis 2000;181:984989.Google Scholar
210. Perl, TM, Cullen, JJ, Wenzel, RP, et al. Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. N Engl J Med 2002;346:18711877.Google Scholar
211. Perl, TM, Roy, MC. Postoperative wound infections: risk factors and role of Staphylococcus aureus nasal carriage. J Chemother 1995;7(suppl 3):2935.Google Scholar
212. von Eiff, C, Becker, K, Machka, K, Stammer, H, Peters, G. Nasal carriage as a source of Staphylococcus aureus bacteremia. N Engl J Med 2001;344:1116.Google Scholar
213. Branger, C, Gardye, C, Lambert-Zechovsky, N. Persistence of Staphylococcus aureus strains among cystic fibrosis patients over extended periods of time. J Med Microbiol 1996;45:294301.Google Scholar
214. Wertheim, HF, Vos, MC, Ott, A, et al. Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. Lancet 2004;364:703705.Google Scholar
215. Stone, A, Quittell, L, Zhou, J, et al. Staphylococcus aureus nasal colonization among pediatric cystic fibrosis patients and their household contacts. Pediatr Infect Dis J 2009;28:895899.Google Scholar
216. Ridder-Schaphorn, S, Ratjen, F, Dubbers, A, et al. Nasal Staphylococcus aureus carriage is not a risk factor for lower-airway infection in young cystic fibrosis patients. J Clin Microbiol 2007;45:29792984.Google Scholar
217. Nadesalingam, K, Conway, SP, Denton, M. Risk factors for acquisition of methicillin-resistant Staphylococcus aureus (MRSA) by patients with cystic fibrosis. J Cyst Fibros 2005;4:4952.Google Scholar
218. Glikman, D, Siegel, JD, David, MZ, et al. Complex molecular epidemiology of methicillin-resistant Staphylococcus aureus isolates from children with cystic fibrosis in the era of epidemic community-associated methicillin-resistant S aureus . Chest 2008;133:13811387.Google Scholar
219. Muhlebach, MS, Miller, M, LaVange, LM, Mayhew, G, Goodrich, JS, Miller, MB. Treatment intensity and characteristics of MRSA infection in CF. J Cyst Fibros 2011;10:201206.Google Scholar
220. Champion, EA, Miller, MB, Popowitch, EB, Hobbs, MM, Saiman, L, Muhlebach, MS. Antimicrobial susceptibility and molecular typing of MRSA in cystic fibrosis. Pediatr Pulmonol 2014;49:230237.Google Scholar
221. Al-Zubeidi, D, Hogan, PG, Boyle, M, Burnham, CA, Fritz, SA. Molecular epidemiology of methicillin-resistant Staphylococcus aureus isolated in serial cultures from the respiratory tract of children with cystic fibrosis. Pediatr Infect Dis J 2014;33:549553.Google Scholar
222. Harris, SR, Cartwright, EJ, Torok, ME, et al. Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study. Lancet Infect Dis 2013;13:130136.Google Scholar
223. Koser, CU, Holden, MT, Ellington, MJ, et al. Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak. N Engl J Med 2012;366:22672275.Google Scholar
224. Vanderhelst, E, De Meirleir, L, Verbanck, S, Pierard, D, Vincken, W, Malfroot, A. Prevalence and impact on FEV1 decline of chronic methicillin-resistant Staphylococcus aureus (MRSA) colonization in patients with cystic fibrosis: a single-center, case control study of 165 patients. J Cyst Fibros 2012;11:27.Google Scholar
225. Sanders, DB, Bittner, RC, Rosenfeld, M, Redding, GJ, Goss, CH. Pulmonary exacerbations are associated with subsequent FEV1 decline in both adults and children with cystic fibrosis. Pediatr Pulmonol 2011;46:393400.Google Scholar
226. Sawicki, GS, Rasouliyan, L, Pasta, DJ, et al. The impact of incident methicillin resistant Staphylococcus aureus detection on pulmonary function in cystic fibrosis. Pediatr Pulmonol 2008;43:11171123.Google Scholar
227. Bange, FC, Brown, BA, Smaczny, C, Wallace, RJ Jr, Bottger, EC. Lack of transmission of Mycobacterium abscessus among patients with cystic fibrosis attending a single clinic. Clin Infect Dis 2001;32:16481650.Google Scholar
228. Jonsson, BE, Gilljam, M, Lindblad, A, Ridell, M, Wold, AE, Welinder-Olsson, C. Molecular epidemiology of Mycobacterium abscessus, with focus on cystic fibrosis. J Clin Microbiol 2007;45:14971504.Google Scholar
229. Tettelin, H, Davidson, RM, Agrawal, S, et al. High-level relatedness among Mycobacterium abscessus subsp. massiliense strains from widely separated outbreaks. Emerg Infect Dis 2014;20:364371.Google Scholar
230. Gross, J, Doan, M, Yamada, S, et al. Mycobacterium abcessus epidemic among cystic fibrosis patients [abstract]. Pediatr Pulmonol 2013;48(suppl 36):302.Google Scholar
231. Chalermskulrat, W, Sood, N, Neuringer, IP, et al. Nontuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation. Thorax 2006;61:507513.Google Scholar
232. Orens, JB, Estenne, M, Arcasoy, S, et al. International guidelines for the selection of lung transplant candidates: 2006 update—a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 2006;25:745755.Google Scholar
233. Huang, HC, Weigt, SS, Derhovanessian, A, et al. Nontuberculous mycobacterium infection after lung transplantation is associated with increased mortality. J Heart Lung Transplant 2011;30:790798.Google Scholar
234. Esther, CR Jr, Esserman, DA, Gilligan, P, Kerr, A, Noone, PG. Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis. J Cyst Fibros 2010;9:117123.Google Scholar
235. Barbier, F, Andremont, A, Wolff, M, Bouadma, L. Hospital-acquired pneumonia and ventilator-associated pneumonia: recent advances in epidemiology and management. Curr Opin Pulm Med 2013;19:216228.Google Scholar
236. Branski, LK, Al-Mousawi, A, Rivero, H, Jeschke, MG, Sanford, AP, Herndon, DN. Emerging infections in burns. Surg Infect (Larchmt) 2009;10:389397.Google Scholar
237. Pendleton, JN, Gorman, SP, Gilmore, BF. Clinical relevance of the ESKAPE pathogens. Expert Rev Anti Infect Ther 2013;11:297308.Google Scholar
238. McCallum, SJ, Gallagher, MJ, Corkill, JE, Hart, CA, Ledson, MJ, Walshaw, MJ. Spread of an epidemic Pseudomonas aeruginosa strain from a patient with cystic fibrosis (CF) to non-CF relatives. Thorax 2002;57:559560.Google Scholar
239. Dy, ME, Nord, JA, LaBombardi, VJ, Germana, J, Walker, P. Lack of throat colonization with Burkholderia cepacia among cystic fibrosis healthcare workers. Infect Control Hosp Epidemiol 1999;20:90.Google Scholar
240. Agochukwu, NQ, Rastinehad, AR, Richter, LA, et al. Prostatic abscess in a pediatric patient with chronic granulomatous disease: report of a unique case and review of the literature. J Pediatr Surg 2012;47:400403.Google Scholar
241. Fishman, JA. Infections in immunocompromised hosts and organ transplant recipients: essentials. Liver Transpl 2011;17(suppl 3):S34S37.Google Scholar
242. Holmes, A, Nolan, R, Taylor, R, et al. An epidemic of Burkholderia cepacia transmitted between patients with and without cystic fibrosis. J Infect Dis 1999;179:11971205.Google Scholar
243. Lowy, FD. Staphylococcus aureus infections. N Engl J Med 1998;339:520532.Google Scholar
244. Chambers, HF. The changing epidemiology of Staphylococcus aureus? Emerg Infect Dis 2001;7:178182.Google Scholar
245. Creech, CB 2nd, Kernodle, DS, Alsentzer, A, Wilson, C, Edwards, KM. Increasing rates of nasal carriage of methicillin-resistant Staphylococcus aureus in healthy children. Pediatr Infect Dis J 2005;24:617621.Google Scholar
246. Kluytmans, J, van Belkum, A, Verbrugh, H. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 1997;10:505520.Google Scholar
247. Lautenbach, E, Tolomeo, P, Nachamkin, I, Hu, B, Zaoutis, TE. The impact of household transmission on duration of outpatient colonization with methicillin-resistant Staphylococcus aureus . Epidemiol Infect 2010;138:683685.Google Scholar
248. Nouwen, JL, Ott, A, Kluytmans-Vandenbergh, MF, et al. Predicting the Staphylococcus aureus nasal carrier state: derivation and validation of a “culture rule.” Clin Infect Dis 2004;39:806811.Google Scholar
249. Gesualdo, F, Bongiorno, D, Rizzo, C, et al. MRSA nasal colonization in children: prevalence meta-analysis, review of risk factors and molecular genetics. Pediatr Infect Dis J 2013;32:479485.Google Scholar
250. Albrich, WC, Harbarth, S. Health-care workers: source, vector, or victim of MRSA? Lancet Infect Dis 2008;8:289301.Google Scholar
251. Hawkins, G, Stewart, S, Blatchford, O, Reilly, J. Should healthcare workers be screened routinely for meticillin-resistant Staphylococcus aureus? a review of the evidence. J Hosp Infect 2011;77:285289.Google Scholar
252. Grant, PS, Charns, LG, Rawot, BW, Benedetti, SG. Consideration to culture health care workers related to increased methicillin-resistant Staphylococcus aureus activity in a neonatal intensive care unit. Am J Infect Control 2008;36:638643.Google Scholar
253. Fritz, SA, Garbutt, J, Elward, A, Shannon, W, Storch, GA. Prevalence of and risk factors for community-acquired methicillin-resistant and methicillin-sensitive Staphylococcus aureus colonization in children seen in a practice-based research network. Pediatrics 2008;121:10901098.Google Scholar
254. Barrett, TW, Moran, GJ. Methicillin-resistant Staphylococcus aureus infections among competitive sports participants—Colorado, Indiana, Pennsylvania, and Los Angeles County, 2000–2003. Ann Emerg Med 2004;43:4347.Google Scholar
255. Kazakova, SV, Hageman, JC, Matava, M, et al. A clone of methicillin-resistant Staphylococcus aureus among professional football players. N Engl J Med 2005;352:468475.Google Scholar
256. Creech, CB, Saye, E, McKenna, BD, et al. One-year surveillance of methicillin-resistant Staphylococcus aureus nasal colonization and skin and soft tissue infections in collegiate athletes. Arch Pediatr Adolesc Med 2010;164:615620.Google Scholar
257. Oller, AR, Province, L, Curless, B. Staphylococcus aureus recovery from environmental and human locations in 2 collegiate athletic teams. J Athl Train 2010;45:222229.Google Scholar
258. Roberts, MC, Soge, OO, No, D, Helgeson, SE, Meschke, JS. Characterization of methicillin-resistant Staphylococcus aureus isolated from public surfaces on a university campus, student homes and local community. J Appl Microbiol 2011;110:15311537.Google Scholar
259. Begier, EM, Frenette, K, Barrett, NL, et al. A high-morbidity outbreak of methicillin-resistant Staphylococcus aureus among players on a college football team, facilitated by cosmetic body shaving and turf burns. Clin Infect Dis 2004;39:14461453.Google Scholar
260. Nguyen, DM, Mascola, L, Brancoft, E. Recurring methicillin-resistant Staphylococcus aureus infections in a football team. Emerg Infect Dis 2005;11:526532.Google Scholar
261. Archibald, LK, Shapiro, J, Pass, A, Rand, K, Southwick, F. Methicillin-resistant Staphylococcus aureus infection in a college football team: risk factors outside the locker room and playing field. Infect Control Hosp Epidemiol 2008;29:450453.Google Scholar
262. Romano, R, Lu, D, Holtom, P. Outbreak of community-acquired methicillin-resistant Staphylococcus aureus skin infections among a collegiate football team. J Athl Train 2006;41:141145.Google Scholar
263. Rihn, JA, Posfay-Barbe, K, Harner, CD, et al. Community-acquired methicillin-resistant Staphylococcus aureus outbreak in a local high school football team: unsuccessful interventions. Pediatr Infect Dis J 2005;24:841843.Google Scholar
264. Bowers, AL, Huffman, GR, Sennett, BJ. Methicillin-resistant Staphylococcus aureus infections in collegiate football players. Med Sci Sports Exerc 2008;40:13621367.Google Scholar
265. Stevens, MP, Bearman, G, Rosato, A, Edmond, M. Community-acquired methicillin resistant Staphylococcus aureus in a women’s collegiate basketball team. South Med J 2008;101:10671068.Google Scholar
266. Lear, A, McCord, G, Peiffer, J, Watkins, RR, Parikh, A, Warrington, S. Incidence of Staphylococcus aureus nasal colonization and soft tissue infection among high school football players. J Am Board Fam Med 2011;24:429435.Google Scholar
267. Lindenmayer, JM, Schoenfeld, S, O’Grady, R, Carney, JK. Methicillin-resistant Staphylococcus aureus in a high school wrestling team and the surrounding community. Arch Intern Med 1998;158:895899.Google Scholar
268. Centers for Disease Control and Prevention. Methicillin-resistant Staphylococcus aureus (MRSA) infections: prevention information and advice for athletes. http://www.cdc.gov/mrsa/groups/advice-for-athletes.html. Published 2010. Accessed October 21, 2013.Google Scholar
269. de Almeida, MB, Zerbinati, RM, Tateno, AF, et al. Rhinovirus C and respiratory exacerbations in children with cystic fibrosis. Emerg Infect Dis 2010;16:996999.Google Scholar
270. Smyth, AR, Smyth, RL, Tong, CY, Hart, CA, Heaf, DP. Effect of respiratory virus infections including rhinovirus on clinical status in cystic fibrosis. Arch Dis Child 1995;73:117120.Google Scholar
271. Wat, D, Gelder, C, Hibbitts, S, et al. The role of respiratory viruses in cystic fibrosis. J Cyst Fibros 2008;7:320328.Google Scholar
272. Hoek, RA, Paats, MS, Pas, SD, et al. Incidence of viral respiratory pathogens causing exacerbations in adult cystic fibrosis patients. Scand J Infect Dis 2013;45:6569.Google Scholar
273. Ortiz, JR, Neuzil, KM, Victor, JC, Wald, A, Aitken, ML, Goss, CH. Influenza-associated cystic fibrosis pulmonary exacerbations. Chest 2010;137:852860.Google Scholar
274. Asner, S, Waters, V, Solomon, M, et al. Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis. J Cyst Fibros 2012;11:433439.Google Scholar
275. Poritz, MA, Blaschke, AJ, Byington, CL, et al. FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: development and application to respiratory tract infection. PLoS ONE 2011;6:e26047.Google Scholar
276. National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention. http://www.cdc.gov/ncezid. Published 2013. Accessed January 13, 2014.Google Scholar
277. Maeda, Y, Stanley, T, Stirling, J, et al. No evidence of transmission of bacteria between reptiles and a CF patient—a case report of a young adult CF patient and reptiles. Zoonoses Public Health 2010;57:e47e53.Google Scholar
278. Ner, Z, Ross, LA, Horn, MV, et al. Bordetella bronchiseptica infection in pediatric lung transplant recipients. Pediatr Transplant 2003;7:413417.Google Scholar
279. Hemsworth, S, Pizer, B. Pet ownership in immunocompromised children—a review of the literature and survey of existing guidelines. Eur J Oncol Nurs 2006;10:117127.Google Scholar
280. Register, KB, Sukumar, N, Palavecino, EL, Rubin, BK, Deora, R. Bordetella bronchiseptica in a paediatric cystic fibrosis patient: possible transmission from a household cat. Zoonoses Public Health 2012;59:246250.Google Scholar
281. Mohan, K, Fothergill, JL, Storrar, J, Ledson, MJ, Winstanley, C, Walshaw, MJ. Transmission of Pseudomonas aeruginosa epidemic strain from a patient with cystic fibrosis to a pet cat. Thorax 2008;63:839840.Google Scholar
282. Loeffler, A, Lloyd, DH. Companion animals: a reservoir for methicillin-resistant Staphylococcus aureus in the community? Epidemiol Infect 2010;138:595605.Google Scholar
283. Ferreira, JP, Fowler, VG Jr, Correa, MT, Lyman, R, Ruffin, F, Anderson, KL. Transmission of methicillin-resistant Staphylococcus aureus between human and hamster. J Clin Microbiol 2011;49:16791680.Google Scholar
284. Lewis, FM, Marsh, BJ, von Reyn, CF. Fish tank exposure and cutaneous infections due to Mycobacterium marinum: tuberculin skin testing, treatment, and prevention. Clin Infect Dis 2003;37:390397.Google Scholar
285. Pandian, TK, Deziel, PJ, Otley, CC, Eid, AJ, Razonable, RR. Mycobacterium marinum infections in transplant recipients: case report and review of the literature. Transpl Infect Dis 2008;10:358363.Google Scholar
286. Centers for Disease Control and Prevention. Healthy Pets Healthy People. http://www.cdc.gov/healthypets/. Published 2013. Accessed January 13, 2014.Google Scholar
287. Lefebvre, SL, Golab, GC, Christensen, E, et al. Guidelines for animal-assisted interventions in health care facilities. Am J Infect Control 2008;36:7885.Google Scholar
288. Curran, KA, Miller, J. Guidelines for animal-assisted interventions in health care facilities. Am J Infect Control 2009;37:257258.Google Scholar
289. US Department of Justice Civil Rights Division. Commonly Asked Questions about Service Animals in Places of Business. http://www.ada.gov/qasrvc.htm. Published 2008. Accessed January 13, 2014.Google Scholar
290. Sheahan, T, Rockx, B, Donaldson, E, et al. Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium. J Virol 2008;82:22742285.Google Scholar
291. Moore, JE, Goldsmith, CE, Millar, BC, et al. Cystic fibrosis and the isolation of Pseudomonas aeruginosa from horses. Vet Rec 2008;163:399400.Google Scholar
292. Chowdhury, P, Heinemann, JA. The general secretory pathway of Burkholderia gladioli pv. agaricicola BG164R is necessary for cavity disease in white button mushrooms. Appl Environ Microbiol 2006;72:35583565.Google Scholar
293. Fiore, A, Laevens, S, Bevivino, A, et al. Burkholderia cepacia complex: distribution of genomovars among isolates from the maize rhizosphere in Italy. Environ Microbiol 2001;3:137143.Google Scholar
294. Miller, SC, LiPuma, JJ, Parke, JL. Culture-based and non-growth-dependent detection of the Burkholderia cepacia complex in soil environments. Appl Environ Microbiol 2002;68:37503758.Google Scholar
295. Ramette, A, LiPuma, JJ, Tiedje, JM. Species abundance and diversity of Burkholderia cepacia complex in the environment. Appl Environ Microbiol 2005;71:11931201.Google Scholar
296. Vermis, K, Brachkova, M, Vandamme, P, Nelis, H. Isolation of Burkholderia cepacia complex genomovars from waters. Syst Appl Microbiol 2003;26:595600.Google Scholar
297. Muhdi, K, Edenborough, FP, Gumery, L, et al. Outcome for patients colonised with Burkholderia cepacia in a Birmingham adult cystic fibrosis clinic and the end of an epidemic. Thorax 1996;51:374377.Google Scholar
298. Coenye, T, Spilker, T, Van Schoor, A, LiPuma, JJ, Vandamme, P. Recovery of Burkholderia cenocepacia strain PHDC from cystic fibrosis patients in Europe. Thorax 2004;59:952954.Google Scholar
299. Fisher, MC, LiPuma, JJ, Dasen, SE, et al. Source of Pseudomonas cepacia: ribotyping of isolates from patients and from the environment. J Pediatr 1993;123:745747.Google Scholar
300. LiPuma, JJ, Spilker, T, Coenye, T, Gonzalez, CF. An epidemic Burkholderia cepacia complex strain identified in soil. Lancet 2002;359:20022003.Google Scholar
301. Baldwin, A, Mahenthiralingam, E, Drevinek, P, et al. Environmental Burkholderia cepacia complex isolates in human infections. Emerg Infect Dis 2007;13:458461.Google Scholar
302. Mahenthiralingam, E, Baldwin, A, Dowson, CG. Burkholderia cepacia complex bacteria: opportunistic pathogens with important natural biology. J Appl Microbiol 2008;104:15391551.Google Scholar
303. McNeely, D, Moore, JE, Elborn, JS, Millar, BC, Rendall, J, Dooley, JS. Isolation of Burkholderia cenocepacia and Burkholderia vietnamiensis from human sewage. Int J Environ Health Res 2009;19:157162.Google Scholar
304. Remold, SK, Brown, CK, Farris, JE, Hundley, TC, Perpich, JA, Purdy, ME. Differential habitat use and niche partitioning by Pseudomonas species in human homes. Microb Ecol 2011;62:505517.Google Scholar
305. Regnath, T, Kreutzberger, M, Illing, S, Oehme, R, Liesenfeld, O. Prevalence of Pseudomonas aeruginosa in households of patients with cystic fibrosis. Int J Hyg Environ Health 2004;207:585588.Google Scholar
306. Schelstraete, P, Van Daele, S, De Boeck, K, et al. Pseudomonas aeruginosa in the home environment of newly infected cystic fibrosis patients. Eur Respir J 2008;31:822829.Google Scholar
307. Barben, J, Hafen, G, Schmid, J. Pseudomonas aeruginosa in public swimming pools and bathroom water of patients with cystic fibrosis. J Cyst Fibros 2005;4:227231.Google Scholar
308. Rosenfeld, M, Emerson, J, McNamara, S, et al. Risk factors for age at initial Pseudomonas acquisition in the cystic fibrosis epic observational cohort. J Cyst Fibros 2012;11:446453.Google Scholar
309. Romling, U, Wingender, J, Muller, H, Tummler, B. A major Pseudomonas aeruginosa clone common to patients and aquatic habitats. Appl Environ Microbiol 1994;60:17341738.Google Scholar
310. Hauben, L, Vauterin, L, Moore, ER, Hoste, B, Swings, J. Genomic diversity of the genus Stenotrophomonas . Int J Syst Bacteriol 1999;49(pt 4):17491760.Google Scholar
311. Spencer, RC. The emergence of epidemic, multiple-antibiotic-resistant Stenotrophomonas (Xanthomonas) maltophilia and Burkholderia (Pseudomonas) cepacia . J Hosp Infect 1995;30(suppl):453464.Google Scholar
312. Kay, SE, Clark, RA, White, KL, Peel, MM. Recurrent Achromobacter piechaudii bacteremia in a patient with hematological malignancy. J Clin Microbiol 2001;39:808810.Google Scholar
313. Falkinham, JO 3rd. Surrounded by mycobacteria: nontuberculous mycobacteria in the human environment. J Appl Microbiol 2009;107:356367.Google Scholar
314. De Groote, MA, Pace, NR, Fulton, K, Falkinham, JO 3rd. Relationships between Mycobacterium isolates from patients with pulmonary mycobacterial infection and potting soils. Appl Environ Microbiol 2006;72:76027606.Google Scholar
315. Fujita, K, Ito, Y, Hirai, T, et al. Genetic relatedness of Mycobacterium avium-intracellulare complex isolates from patients with pulmonary MAC disease and their residential soils. Clin Microbiol Infect 2013;19:537541.Google Scholar
316. Decker, BK, Palmore, TN. The role of water in healthcare-associated infections. Curr Opin Infect Dis 2013;26:345351.Google Scholar
317. Festini, F, Taccetti, G, Mannini, C, et al. Patient risk of contact with respiratory pathogens from inanimate surfaces in a cystic fibrosis outpatient clinic: a prospective study over a four-year period. Pediatr Pulmonol 2007;42:779784.Google Scholar
318. Klausner, JD, Zukerman, C, Limaye, AP, Corey, L. Outbreak of Stenotrophomonas maltophilia bacteremia among patients undergoing bone marrow transplantation: association with faulty replacement of handwashing soap. Infect Control Hosp Epidemiol 1999;20:756758.Google Scholar
319. Weber, DJ, Rutala, WA, Blanchet, CN, Jordan, M, Gergen, MF. Faucet aerators: a source of patient colonization with Stenotrophomonas maltophilia . Am J Infect Control 1999;27:5963.Google Scholar
320. Denton, M, Rajgopal, A, Mooney, L, et al. Stenotrophomonas maltophilia contamination of nebulizers used to deliver aerosolized therapy to inpatients with cystic fibrosis. J Hosp Infect 2003;55:180183.Google Scholar
321. Valdezate, S, Vindel, A, Martin-Davila, P, Del Saz, BS, Baquero, F, Canton, R. High genetic diversity among Stenotrophomonas maltophilia strains despite their originating at a single hospital. J Clin Microbiol 2004;42:693699.Google Scholar
322. Donskey, CJ. Does improving surface cleaning and disinfection reduce health care–associated infections? Am J Infect Control 2013;41:S12S19.Google Scholar
323. Harris, AD. How important is the environment in the emergence of nosocomial antimicrobial-resistant bacteria? Clin Infect Dis 2008;46:686688.Google Scholar
324. Otter, JA, Yezli, S, French, GL. The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Control Hosp Epidemiol 2011;32:687699.Google Scholar
325. Weber, DJ, Rutala, WA, Miller, MB, Huslage, K, Sickbert-Bennett, E. Role of hospital surfaces in the transmission of emerging health care–associated pathogens: norovirus, Clostridium difficile, and Acinetobacter species. Am J Infect Control 2010;38:S25S33.Google Scholar
326. Hota, B, Blom, DW, Lyle, EA, Weinstein, RA, Hayden, MK. Interventional evaluation of environmental contamination by vancomycin-resistant enterococci: failure of personnel, product, or procedure? J Hosp Infect 2009;71:123131.Google Scholar
327. Boyce, JM, Havill, NL, Otter, JA, Adams, NM. Widespread environmental contamination associated with patients with diarrhea and methicillin-resistant Staphylococcus aureus colonization of the gastrointestinal tract. Infect Control Hosp Epidemiol 2007;28:11421147.Google Scholar
328. Edmond, MB, Wenzel, RP, Pasculle, AW. Vancomycin-resistant Staphylococcus aureus: perspectives on measures needed for control. Ann Intern Med 1996;124:329334.Google Scholar
329. Weber, DJ, Anderson, D, Rutala, WA. The role of the surface environment in healthcare-associated infections. Curr Opin Infect Dis 2013;26:338344.Google Scholar
330. Vajravelu, RK, Guerrero, DM, Jury, LA, Donskey, CJ. Evaluation of stethoscopes as vectors of Clostridium difficile and methicillin-resistant Staphylococcus aureus . Infect Control Hosp Epidemiol 2012;33:9698.Google Scholar
331. Blydt-Hansen, T, Subbarao, K, Quennec, P, McDonald, J. Recovery of respiratory syncytial virus from stethoscopes by conventional viral culture and polymerase chain reaction. Pediatr Infect Dis J 1999;18:164165.Google Scholar
332. Kerr, JR, Martin, H, Chadwick, MV, Edwards, A, Hodson, ME, Geddes, DM. Evidence against transmission of Pseudomonas aeruginosa by hands and stethoscopes in a cystic fibrosis unit. J Hosp Infect 2002;50:324326.Google Scholar
333. Muscarella, LF. Prevention of disease transmission during flexible laryngoscopy. Am J Infect Control 2007;35:536544.Google Scholar
334. Muscarella, LF. Recommendations to resolve inconsistent guidelines for the reprocessing of sheathed and unsheathed rigid laryngoscopes. Infect Control Hosp Epidemiol 2007;28:504507.Google Scholar
335. Bou, R, Aguilar, A, Perpinan, J, et al. Nosocomial outbreak of Pseudomonas aeruginosa infections related to a flexible bronchoscope. J Hosp Infect 2006;64:129135.Google Scholar
336. DiazGranados, CA, Jones, MY, Kongphet-Tran, T, et al. Outbreak of Pseudomonas aeruginosa infection associated with contamination of a flexible bronchoscope. Infect Control Hosp Epidemiol 2009;30:550555.Google Scholar
337. Kirschke, DL, Jones, TF, Craig, AS, et al. Pseudomonas aeruginosa and Serratia marcescens contamination associated with a manufacturing defect in bronchoscopes. N Engl J Med 2003;348:214220.Google Scholar
338. Shimono, N, Takuma, T, Tsuchimochi, N, et al. An outbreak of Pseudomonas aeruginosa infections following thoracic surgeries occurring via the contamination of bronchoscopes and an automatic endoscope reprocessor. J Infect Chemother 2008;14:418423.Google Scholar
339. Phillips, MS, von Reyn, CF. Nosocomial infections due to nontuberculous mycobacteria. Clin Infect Dis 2001;33:13631374.Google Scholar
340. Begg, N, O’Mahony, M, Penny, P, Richardson, EA. Mycobacterium chelonei associated with a hospital hydrotherapy pool. Community Med 1986;8:348350.Google Scholar
341. Jones, AM, Govan, JR, Doherty, CJ, et al. Identification of airborne dissemination of epidemic multiresistant strains of Pseudomonas aeruginosa at a CF centre during a cross infection outbreak. Thorax 2003;58:525527.Google Scholar
342. Jimenez, L. Microbial diversity in pharmaceutical product recalls and environments. PDA J Pharm Sci Technol 2007;61:383399.Google ScholarPubMed
343. Torbeck, L, Raccasi, D, Guilfoyle, DE, Friedman, RL, Hussong, D. Burkholderia cepacia: this decision is overdue. PDA J Pharm Sci Technol 2011;65:535543.Google Scholar
344. Weber, DJ, Rutala, WA, Sickbert-Bennett, EE. Outbreaks associated with contaminated antiseptics and disinfectants. Antimicrob Agents Chemother 2007;51:42174224.Google Scholar
345. Balkhy, HH, Cunningham, G, Francis, C, et al. A National Guard outbreak of Burkholderia cepacia infection and colonization secondary to intrinsic contamination of albuterol nebulization solution. Am J Infect Control 2005;33:182188.CrossRefGoogle ScholarPubMed
346. Berthelot, P, Grattard, F, Mahul, P, et al. Ventilator temperature sensors: an unusual source of Pseudomonas cepacia in nosocomial infection. J Hosp Infect 1993;25:3343.Google Scholar
347. Burdge, DR, Nakielna, EM, Noble, MA. Case-control and vector studies of nosocomial acquisition of Pseudomonas cepacia in adult patients with cystic fibrosis. Infect Control Hosp Epidemiol 1993;14:127130.Google Scholar
348. Estivariz, CF, Bhatti, LI, Pati, R, et al. An outbreak of Burkholderia cepacia associated with contamination of albuterol and nasal spray. Chest 2006;130:13461353.Google Scholar
349. Hamill, RJ, Houston, ED, Georghiou, PR, et al. An outbreak of Burkholderia (formerly Pseudomonas) cepacia respiratory tract colonization and infection associated with nebulized albuterol therapy. Ann Intern Med 1995;122:762766.Google Scholar
350. Hutchinson, J, Runge, W, Mulvey, M, et al. Burkholderia cepacia infections associated with intrinsically contaminated ultrasound gel: the role of microbial degradation of parabens. Infect Control Hosp Epidemiol 2004;25:291296.Google Scholar
351. Kutty, PK, Moody, B, Gullion, JS, et al. Multistate outbreak of Burkholderia cenocepacia colonization and infection associated with the use of intrinsically contaminated alcohol-free mouthwash. Chest 2007;132:18251831.Google Scholar
352. Loukil, C, Saizou, C, Doit, C, et al. Epidemiologic investigation of Burkholderia cepacia acquisition in two pediatric intensive care units. Infect Control Hosp Epidemiol 2003;24:707710.Google Scholar
353. Molina-Cabrillana, J, Bolanos-Rivero, M, Alvarez-Leon, EE, et al. Intrinsically contaminated alcohol-free mouthwash implicated in a nosocomial outbreak of Burkholderia cepacia colonization and infection. Infect Control Hosp Epidemiol 2006;27:12811282.Google Scholar
354. Nasser, RM, Rahi, AC, Haddad, MF, Daoud, Z, Irani-Hakime, N, Almawi, WY. Outbreak of Burkholderia cepacia bacteremia traced to contaminated hospital water used for dilution of an alcohol skin antiseptic. Infect Control Hosp Epidemiol 2004;25:231239.Google Scholar
355. Panlilio, AL, Beck-Sague, CM, Siegel, JD, et al. Infections and pseudoinfections due to povidone-iodine solution contaminated with Pseudomonas cepacia . Clin Infect Dis 1992;14:10781083.Google Scholar
356. Pegues, CF, Pegues, DA, Ford, DS, et al. Burkholderia cepacia respiratory tract acquisition: epidemiology and molecular characterization of a large nosocomial outbreak. Epidemiol Infect 1996;116:309317.Google Scholar
357. Ramsey, AH, Skonieczny, P, Coolidge, DT, Kurzynski, TA, Proctor, ME, Davis, JP. Burkholderia cepacia lower respiratory tract infection associated with exposure to a respiratory therapist. Infect Control Hosp Epidemiol 2001;22:423426.Google Scholar
358. Reboli, AC, Koshinski, R, Arias, K, Marks-Austin, K, Stieritz, D, Stull, TL. An outbreak of Burkholderia cepacia lower respiratory tract infection associated with contaminated albuterol nebulization solution. Infect Control Hosp Epidemiol 1996;17:741743.Google Scholar
359. Romero-Gomez, MP, Quiles-Melero, MI, Pena Garcia, P, et al. Outbreak of Burkholderia cepacia bacteremia caused by contaminated chlorhexidine in a hemodialysis unit. Infect Control Hosp Epidemiol 2008;29:377378.Google Scholar
360. Takigawa, K, Fujita, J, Negayama, K, et al. Nosocomial outbreak of Pseudomonas cepacia respiratory infection in immunocompromised patients associated with contaminated nebulizer devices. Kansenshogaku Zasshi 1993;67:11151125.Google Scholar
361. Weber, DJ, Wilson, MB, Rutala, WA, Thomann, CA. Manual ventilation bags as a source for bacterial colonization of intubated patients. Am Rev Respir Dis 1990;142:892894.Google Scholar
362. Weems, JJ Jr. Nosocomial outbreak of Pseudomonas cepacia associated with contamination of reusable electronic ventilator temperature probes. Infect Control Hosp Epidemiol 1993;14:583586.Google Scholar
363. Keen, M, Foreman, A, Wormald, PJ. The clinical significance of nasal irrigation bottle contamination. Laryngoscope 2010;120:21102114.Google Scholar
364. Welch, KC, Cohen, MB, Doghramji, LL, et al. Clinical correlation between irrigation bottle contamination and clinical outcomes in post-functional endoscopic sinus surgery patients. Am J Rhinol Allergy 2009;23:401404.Google Scholar
365. Koh, SJ, Song, T, Kang, YA, et al. An outbreak of skin and soft tissue infection caused by Mycobacterium abscessus following acupuncture. Clin Microbiol Infect 2010;16:895901.Google Scholar
366. Newman, MI, Camberos, AE, Clynes, ND, Ascherman, JA. Outbreak of atypical mycobacteria infections in U.S. patients traveling abroad for cosmetic surgery. Plast Reconstr Surg 2005;115:964965.Google Scholar
367. Liu, L, Coenye, T, Burns, JL, Whitby, PW, Stull, TL, LiPuma, JJ. Ribosomal DNA–directed PCR for identification of Achromobacter (Alcaligenes) xylosoxidans recovered from sputum samples from cystic fibrosis patients. J Clin Microbiol 2002;40:12101213.Google Scholar
368. Kennedy, BS, Bedard, B, Younge, M, et al. Outbreak of Mycobacterium chelonae infection associated with tattoo ink. N Engl J Med 2012;367:10201024.Google Scholar
369. Winthrop, KL, Abrams, M, Yakrus, M, et al. An outbreak of mycobacterial furunculosis associated with footbaths at a nail salon. N Engl J Med 2002;346:13661371.Google Scholar
370. Haiduven, D. Nosocomial aspergillosis and building construction. Med Mycol 2009;47(suppl 1):S210S216.Google Scholar
371. Vonberg, RP, Gastmeier, P. Nosocomial aspergillosis in outbreak settings. J Hosp Infect 2006;63:246254.Google Scholar
372. Weber, DJ, Peppercorn, A, Miller, MB, Sickbert-Benett, E, Rutala, WA. Preventing healthcare-associated Aspergillus infections: review of recent CDC/HICPAC recommendations. Med Mycol 2009;47(suppl 1):S199S209.Google Scholar
373. Ashish, A, Shaw, M, Winstanley, C, Humphreys, L, Walshaw, MJ. Halting the spread of epidemic Pseudomonas aeruginosa in an adult cystic fibrosis centre: a prospective cohort study. JRSM Short Rep 2013;4:1.Google Scholar
374. Festini, F, Buzzetti, R, Bassi, C, et al. Isolation measures for prevention of infection with respiratory pathogens in cystic fibrosis: a systematic review. J Hosp Infect 2006;64:16.Google Scholar
375. Griffiths, AL, Wurzel, DF, Robinson, PJ, Carzino, R, Massie, J. Australian epidemic strain pseudomonas (AES-1) declines further in a cohort segregated cystic fibrosis clinic. J Cyst Fibros 2012;11:4952.Google Scholar
376. Conway, S. Segregation is good for patients with cystic fibrosis. J R Soc Med 2008;101(suppl 1):S31S35.Google Scholar
377. Resar, R, Griffin, F, Haraden, C, Nolan, T. Using Care Bundles to Improve Health Care Quality. Institute for Healthcare Improvement (IHI) Innovation Series white paper. Cambridge, MA: IHI, 2012.Google Scholar
378. Kaier, K, Wilson, C, Hulscher, M, et al. Implementing strategic bundles for infection prevention and management. Infection 2012;40:225228.Google Scholar
379. Marwick, C, Davey, P. Care bundles: the holy grail of infectious risk management in hospital? Curr Opin Infect Dis 2009;22:364369.Google Scholar
380. Centers for Disease Control and Prevention. Cover Your Cough. http://www.cdc.gov/flu/protect/covercough.htm. Published 2010. Accessed January 13, 2014.Google Scholar
381. Miroballi, Y, Garber, E, Jia, H, et al. Infection control knowledge, attitudes, and practices among cystic fibrosis patients and their families. Pediatr Pulmonol 2012;47:144152.Google Scholar
382. Saiman, L, Garber, E. Infection control in cystic fibrosis: barriers to implementation and ideas for improvement. Curr Opin Pulm Med 2009;15:626631.Google Scholar
383. Cooper, T. Putting educational theory into clinical practice. J Hosp Infect 2007;65(suppl 2):124127.Google Scholar
384. Ferguson, PE, Jordens, CF, Gilroy, NM. Patient and family education in HSCT: improving awareness of respiratory virus infection and influenza vaccination. A descriptive study and brief intervention. Bone Marrow Transplant 2010;45:656661.Google Scholar
385. Larson, EL. New rules for the game: interdisciplinary education for health professionals. 1995. Nurs Outlook 2012;60:264270.Google Scholar
386. Matlow, AG, Wray, R, Richardson, SE. Attitudes and beliefs, not just knowledge, influence the effectiveness of environmental cleaning by environmental service workers. Am J Infect Control 2012;40:260262.Google Scholar
387. O’Boyle, CA, Henly, SJ, Larson, E. Understanding adherence to hand hygiene recommendations: the theory of planned behavior. Am J Infect Control 2001;29:352360.Google Scholar
388. Erasmus, V, Brouwer, W, van Beeck, EF, et al. A qualitative exploration of reasons for poor hand hygiene among hospital workers: lack of positive role models and of convincing evidence that hand hygiene prevents cross-infection. Infect Control Hosp Epidemiol 2009;30:415419.Google Scholar
389. Positive Deviance Initiative. What Is Positive Deviance? http://www.positivedeviance.org. Published 2010. Accessed January 13, 2014.Google Scholar
390. Marra, AR, Guastelli, LR, de Araujo, CM, et al. Positive deviance: a new strategy for improving hand hygiene compliance. Infect Control Hosp Epidemiol 2010;31:1220.Google Scholar
391. Hysong, SJ, Best, RG, Pugh, JA. Audit and feedback and clinical practice guideline adherence: making feedback actionable. Implement Sci 2006;1:9.Google Scholar
392. Larson, EL, Patel, SJ, Evans, D, Saiman, L. Feedback as a strategy to change behaviour: the devil is in the details. J Eval Clin Pract 2013;19:230234.Google Scholar
393. Boyce, JM, Pittet, D; Society for Healthcare Epidemiology of America, Association for Professionals in Infection Control, Infectious Diseases Society of America. Guideline for hand hygiene in health-care settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. MMWR Recomm Rep 2002;51:145.Google Scholar
394. Pittet, D, Allegranzi, B, Boyce, J. The World Health Organization guidelines on hand hygiene in health care and their consensus recommendations. Infect Control Hosp Epidemiol 2009;30:611622.Google Scholar
395. Aiello, AE, Coulborn, RM, Perez, V, Larson, EL. Effect of hand hygiene on infectious disease risk in the community setting: a meta-analysis. Am J Public Health 2008;98:13721381.Google Scholar
396. Warren-Gash, C, Fragaszy, E, Hayward, AC. Hand hygiene to reduce community transmission of influenza and acute respiratory tract infection: a systematic review. Influenza Other Respir Viruses 2013;7:738749.Google Scholar
397. Aiello, AE, Larson, EL, Levy, SB. Consumer antibacterial soaps: effective or just risky? Clin Infect Dis 2007;45(suppl 2):S137S147.Google Scholar
398. McGinley, KJ, Larson, EL, Leyden, JJ. Composition and density of microflora in the subungual space of the hand. J Clin Microbiol 1988;26:950953.Google Scholar
399. Hedderwick, SA, McNeil, SA, Lyons, MJ, Kauffman, CA. Pathogenic organisms associated with artificial fingernails worn by healthcare workers. Infect Control Hosp Epidemiol 2000;21:505509.Google Scholar
400. McNeil, SA, Foster, CL, Hedderwick, SA, Kauffman, CA. Effect of hand cleansing with antimicrobial soap or alcohol-based gel on microbial colonization of artificial fingernails worn by health care workers. Clin Infect Dis 2001;32:367372.Google Scholar
401. Pottinger, J, Burns, S, Manske, C. Bacterial carriage by artificial versus natural nails. Am J Infect Control 1989;17:340344.Google Scholar
402. Parry, MF, Grant, B, Yukna, M, et al. Candida osteomyelitis and diskitis after spinal surgery: an outbreak that implicates artificial nail use. Clin Infect Dis 2001;32:352357.Google Scholar
403. Gordin, FM, Schultz, ME, Huber, R, Zubairi, S, Stock, F, Kariyil, J. A cluster of hemodialysis-related bacteremia linked to artificial fingernails. Infect Control Hosp Epidemiol 2007;28:743744.Google Scholar
404. Moolenaar, RL, Crutcher, JM, San Joaquin, VH, et al. A prolonged outbreak of Pseudomonas aeruginosa in a neonatal intensive care unit: did staff fingernails play a role in disease transmission? Infect Control Hosp Epidemiol 2000;21:8085.Google Scholar
405. Gupta, A, Della-Latta, P, Todd, B, et al. Outbreak of extended-spectrum β-lactamase–producing Klebsiella pneumoniae in a neonatal intensive care unit linked to artificial nails. Infect Control Hosp Epidemiol 2004;25:210215.Google Scholar
406. US Food and Drug Administration. About Personal Protective Equipment (PPE). http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/GeneralHospitalDevicesandSupplies/PersonalProtectiveEquipment/ucm055943.htm. Published 2010. Accessed January 13, 2014.Google Scholar
407. Harris, AD, Pineles, L, Belton, B, et al. Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial. JAMA 2013;310:15711580.Google Scholar
408. Morgan, DJ, Liang, SY, Smith, CL, et al. Frequent multidrug-resistant Acinetobacter baumannii contamination of gloves, gowns, and hands of healthcare workers. Infect Control Hosp Epidemiol 2010;31:716721.Google Scholar
409. Perry, C, Marshall, R, Jones, E. Bacterial contamination of uniforms. J Hosp Infect 2001;48:238241.Google Scholar
410. Zachary, KC, Bayne, PS, Morrison, VJ, Ford, DS, Silver, LC, Hooper, DC. Contamination of gowns, gloves, and stethoscopes with vancomycin-resistant enterococci. Infect Control Hosp Epidemiol 2001;22:560564.Google Scholar
411. Bearman, GM, Marra, AR, Sessler, CN, et al. A controlled trial of universal gloving versus contact precautions for preventing the transmission of multidrug-resistant organisms. Am J Infect Control 2007;35:650655.Google Scholar
412. Tenorio, AR, Badri, SM, Sahgal, NB, et al. Effectiveness of gloves in the prevention of hand carriage of vancomycin-resistant enterococcus species by health care workers after patient care. Clin Infect Dis 2001;32:826829.Google Scholar
413. Trick, WE, Vernon, MO, Welbel, SF, Demarais, P, Hayden, MK, Weinstein, RA. Multicenter intervention program to increase adherence to hand hygiene recommendations and glove use and to reduce the incidence of antimicrobial resistance. Infect Control Hosp Epidemiol 2007;28:4249.Google Scholar
414. Gammon, J, Morgan-Samuel, H, Gould, D. A review of the evidence for suboptimal compliance of healthcare practitioners to standard/universal infection control precautions. J Clin Nurs 2008;17:157167.Google Scholar
415. US Department of Labor. Occupational Safety and Health Administration regulations 1910.134: respiratory protection. https://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STANDARDS&p_id=12716. Published 2011. Accessed January 13, 2014.Google Scholar
416. Carling, PC, Huang, SS. Improving healthcare environmental cleaning and disinfection: current and evolving issues. Infect Control Hosp Epidemiol 2013;34:507513.Google Scholar
417. Strausbaugh, LJ, Siegel, JD, Weinstein, RA. Preventing transmission of multidrug-resistant bacteria in health care settings: a tale of 2 guidelines. Clin Infect Dis 2006;42:828835.Google Scholar
418. Passaretti, CL, Otter, JA, Reich, NG, et al. An evaluation of environmental decontamination with hydrogen peroxide vapor for reducing the risk of patient acquisition of multidrug-resistant organisms. Clin Infect Dis 2013;56:2735.Google Scholar
419. Centers for Disease Control and Prevention. Options for Evaluating Environmental Cleaning. http://www.cdc.gov/HAI/toolkits/Evaluating-Environmental-Cleaning.html. Published 2010. Accessed January 13, 2014.Google Scholar
420. Boyce, JM, Havill, NL, Havill, HL, Mangione, E, Dumigan, DG, Moore, BA. Comparison of fluorescent marker systems with 2 quantitative methods of assessing terminal cleaning practices. Infect Control Hosp Epidemiol 2011;32:11871193.Google Scholar
421. Rutala, WA, Weber, DJ. New developments in reprocessing semicritical items. Am J Infect Control 2013;41:S60S66.Google Scholar
422. Harbarth, S, Sudre, P, Dharan, S, Cadenas, M, Pittet, D. Outbreak of Enterobacter cloacae related to understaffing, overcrowding, and poor hygiene practices. Infect Control Hosp Epidemiol 1999;20:598603.Google Scholar
423. Sheth, NK, Post, GT, Wisniewski, TR, Uttech, BV. Multidose vials versus single-dose vials: a study in sterility and cost-effectiveness. J Clin Microbiol 1983;17:377379.Google Scholar
424. Guidelines for preventing health-care-associated pneumonia, 2003 recommendations of the CDC and the Healthcare Infection Control Practices Advisory Committee. Respir Care 2004;49:926939.Google Scholar
425. Ari, A, Restrepo, RD. Aerosol delivery device selection for spontaneously breathing patients: 2012. Respir Care 2012;57:613626.Google Scholar
426. Lester, MK, Flume, PA, Gray, SL, Anderson, D, Bowman, CM. Nebulizer use and maintenance by cystic fibrosis patients: a survey study. Respir Care 2004;49:15041508.Google Scholar
427. O’Malley, CA, VandenBranden, SL, Zheng, XT, Polito, AM, McColley, SA. A day in the life of a nebulizer: surveillance for bacterial growth in nebulizer equipment of children with cystic fibrosis in the hospital setting. Respir Care 2007;52:258262.Google Scholar
428. Hutchinson, GR, Parker, S, Pryor, JA, et al. Home-use nebulizers: a potential primary source of Burkholderia cepacia and other colistin-resistant, gram-negative bacteria in patients with cystic fibrosis. J Clin Microbiol 1996;34:584587.Google Scholar
429. Jakobsson, BM, Onnered, AB, Hjelte, L, Nystrom, B. Low bacterial contamination of nebulizers in home treatment of cystic fibrosis patients. J Hosp Infect 1997;36:201207.Google Scholar
430. Pitchford, KC, Corey, M, Highsmith, AK, et al. Pseudomonas species contamination of cystic fibrosis patients’ home inhalation equipment. J Pediatr 1987;111:212216.Google Scholar
431. Rosenfeld, M, Joy, P, Nguyen, CD, Krzewinski, J, Burns, JL. Cleaning home nebulizers used by patients with cystic fibrosis: is rinsing with tap water enough? J Hosp Infect 2001;49:229230.Google Scholar
432. Blau, H, Mussaffi, H, Mei Zahav, M, et al. Microbial contamination of nebulizers in the home treatment of cystic fibrosis. Child Care Health Dev 2007;33:491495.Google Scholar
433. Best, M, Sattar, SA, Springthorpe, VS, Kennedy, ME. Comparative mycobactericidal efficacy of chemical disinfectants in suspension and carrier tests. Appl Environ Microbiol 1988;54:28562858.Google Scholar
434. Merritt, K, Hitchins, VM, Brown, SA. Safety and cleaning of medical materials and devices. J Biomed Mater Res 2000;53:131136.Google Scholar
435. Rosaspina, S, Salvatorelli, G, Anzanel, D. The bactericidal effect of microwaves on Mycobacterium bovis dried on scalpel blades. J Hosp Infect 1994;26:4550.Google Scholar
436. Rosaspina, S, Salvatorelli, G, Anzanel, D, Bovolenta, R. Effect of microwave radiation on Candida albicans . Microbios 1994;78:5559.Google Scholar
437. Sanborn, MR, Wan, SK, Bulard, R. Microwave sterilization of plastic tissue culture vessels for reuse. Appl Environ Microbiol 1982;44:960964.Google Scholar
438. Towle, D, Callan, DA, Farrel, PA, Egan, ME, Murray, TS. Baby bottle steam sterilizers disinfect home nebulizers inoculated with bacterial respiratory pathogens. J Cyst Fibros 2013;12:512516.Google Scholar
439. Rutala, WA, ed. Disinfection, Sterilization and Antisepsis in Health Care. Champlain, NY: Polyscience Publications, 1998:133149.Google Scholar
440. Luebbert, P. Home care. In: Olmstead, R, ed. APIC Text of Infection Control and Epidemiology: Principles and Practice. Washington, DC: Association for Professionals in Infection Control and Epidemiology, 2000:4447.Google Scholar
441. Karapinar, M, Gonul, SA. Effects of sodium bicarbonate, vinegar, acetic and citric acids on growth and survival of Yersinia enterocolitica . Int J Food Microbiol 1992;16:343347.Google Scholar
442. Rutala, WA, Barbee, SL, Aguiar, NC, Sobsey, MD, Weber, DJ. Antimicrobial activity of home disinfectants and natural products against potential human pathogens. Infect Control Hosp Epidemiol 2000;21:3338.Google Scholar
443. Reychler, G, Leonard, A, Van Ossel, C, et al. Impact of hypochlorite-based disinfection on bacterial contamination of cystic fibrosis patients’ home-nebulisers. J Hosp Infect 2009;72:351357.Google Scholar
444. Jones, AM, Dodd, ME, Govan, JR, et al. Prospective surveillance for Pseudomonas aeruginosa cross-infection at a cystic fibrosis center. Am J Respir Crit Care Med 2005;171:257260.Google Scholar
445. McKay, KO, Cooper, PJ, van Asperen, PP. Segregation of children with CF diagnosed via newborn screening and acquisition of Pseudomonas aeruginosa . J Cyst Fibros 2009;8:400404.Google Scholar
446. Wiehlmann, L, Cramer, N, Ulrich, J, Hedtfeld, S, Weissbrodt, H, Tummler, B. Effective prevention of Pseudomonas aeruginosa cross-infection at a cystic fibrosis centre—results of a 10-year prospective study. Int J Med Microbiol 2012;302:6977.Google Scholar
447. Saiman, L. Infection prevention and control in cystic fibrosis. Curr Opin Infect Dis 2011;24:390395.Google Scholar
448. Ledson, MJ, Gallagher, MJ, Corkill, JE, Hart, CA, Walshaw, MJ. Cross infection between cystic fibrosis patients colonised with Burkholderia cepacia . Thorax 1998;53:432436.Google Scholar
449. Zhou, J, Garber, E, Saiman, L. Survey of infection control policies for patients with cystic fibrosis in the United States. Am J Infect Control 2008;36:220222.Google Scholar
450. Centers for Disease Control and Prevention. Stopping the Spread of Germs at Home, Work, and School. http://www.cdc.gov/flu/protect/stopgerms.htm. Published 2013. Accessed January 13, 2014.Google Scholar
451. Centers for Disease Control and Prevention. Building Air Quality: A Guide for Building Owners and Facility Managers. http://www.cdc.gov/niosh/docs/91-114/. Published 1991. Accessed January 13, 2014.Google Scholar
452. Rutala, WA, Jones, SM, Worthington, JM, Reist, PC, Weber, DJ. Efficacy of portable filtration units in reducing aerosolized particles in the size range of Mycobacterium tuberculosis . Infect Control Hosp Epidemiol 1995;16:391398.Google Scholar
453. Manning, ML, Davis, J, Sparnon, E, Ballard, RM. iPads, droids, and bugs: infection prevention for mobile handheld devices at the point of care. Am J Infect Control 2013;41:10731076.Google Scholar
454. Guzman-Cottrill, JA, Ravin, KA, Bryant, KA, Zerr, DM, Kociolek, L, Siegel, JD. Infection prevention and control in residential facilities for pediatric patients and their families. Infect Control Hosp Epidemiol 2013;34:10031041.Google Scholar
455. Hoogkamp-Korstanje, JA, Meis, JF, Kissing, J, van der Laag, J, Melchers, WJ. Risk of cross-colonization and infection by Pseudomonas aeruginosa in a holiday camp for cystic fibrosis patients. J Clin Microbiol 1995;33:572575.Google Scholar
456. Ojeniyi, B, Frederiksen, B, Hoiby, N. Pseudomonas aeruginosa cross-infection among patients with cystic fibrosis during a winter camp. Pediatr Pulmonol 2000;29:177181.Google Scholar
457. Brimicombe, RW, Dijkshoorn, L, van der Reijden, TJ, et al. Transmission of Pseudomonas aeruginosa in children with cystic fibrosis attending summer camps in the Netherlands. J Cyst Fibros 2008;7:3036.Google Scholar
458. Centers for Disease Control and Prevention. Influenza Antiviral Medications: Summary for Clinicians. http://www.cdc.gov/flu/professionals/antivirals/summary-clinicians.htm. Published 2013. Accessed January 13, 2014.Google Scholar
459. General recommendations on immunization—recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2011;60:164.Google Scholar
460. Centers for Disease Control and Prevention. Immunization Schedules. http://www.cdc.gov/vaccines/schedules/index.html. Published 2013. Accessed January 13, 2014.Google Scholar
461. Centers for Disease Control and Prevention. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among children aged 6–18 years with immunocompromising conditions: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 2013;62:521524.Google Scholar
462. Doring, G, Pier, GB. Vaccines and immunotherapy against Pseudomonas aeruginosa . Vaccine 2008;26:10111024.Google Scholar
463. Fowler, VG, Allen, KB, Moreira, ED, et al. Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial. JAMA 2013;309:13681378.Google Scholar
464. Sharma, A, Krause, A, Worgall, S. Recent developments for Pseudomonas vaccines. Hum Vaccin 2011;7:9991011.Google Scholar
465. Centers for Disease Control and Prevention. Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices—United States, 2013–2014. MMWR Recomm Rep 2013;62:143.Google Scholar
466. Grizas, AP, Camenga, D, Vazquez, M. Cocooning: a concept to protect young children from infectious diseases. Curr Opin Pediatr 2012;24:9297.Google Scholar
467. Zaman, K, Roy, E, Arifeen, SE, et al. Effectiveness of maternal influenza immunization in mothers and infants. N Engl J Med 2008;359:15551564.Google Scholar
468. Eick, AA, Uyeki, TM, Klimov, A, et al. Maternal influenza vaccination and effect on influenza virus infection in young infants. Arch Pediatr Adolesc Med 2011;165:104111.Google Scholar
469. Rubin, LG, Levin, MJ, Ljungman, P, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host.