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Maximizing Infection Prevention in the Next Decade: Defining the Unacceptable

  • Thomas R. Frieden (a1)
  • DOI:
  • Published online: 01 January 2015

An important role of public health agencies is to define the unacceptable. This concept has particular relevance for healthcare-associated infections. Evidence indicates that, with focused efforts, these once-formidable infections can be greatly reduced in number, leading to a new normal for healthcare-associated infections as rare, unacceptable events.

Corresponding author
Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333 (
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6.P Pronovost , D Needham , S Berenholtz , et al.An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 2006;355(26):2725–32.

, , , . ;():–.7.DC Burton JR Edwards TC Horan et al.Methicillin-resistant central line-associated bloodstream infections in US intensive care units, 1997–2007Staphylococcus aureus JAMA 2009 301 7 727736

8.D Pittet , D Tarara , R Wenzel . Nosocomial bloodstream infection in critically ill patients: excess length of stay, extra costs, and attributable mortality. JAMA 1994;271(20):15981601.

9.B Renaud , C Brun-Buisson , for the ICU-Bacteremia Study Group. Outcomes of primary and catheter-related bacteremia: a cohort and case-control study in critically ill patients. Am J Respir Crit Care Med 2001;163(7):15841590.

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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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