Skip to main content
×
Home
    • Aa
    • Aa

Moxifloxacin Therapy as a Risk Factor for Clostridium difficile–Associated Disease During an Outbreak: Attempts to Control a New Epidemic Strain

  • Priscilla Biller (a1), Beth Shank (a1), Leah Lind (a2), Meghan Brennan (a3), Lisa Tkatch (a1), George Killgore (a3), Angela Thompson (a3) and L. Clifford McDonald (a3)...
Abstract

An outbreak of Clostridium difficile-associated disease (CDAD) caused by the epidemic North American pulsed-field gel electrophoresis type 1 (NAP1) strain began after a formulary change from levofloxacin to moxifloxacin. Cases of CDAD were associated with moxifloxacin use, but a formulary change back to levofloxacin failed to reduce rates of disease. Substituting use of one fluoroquinolone with use of another without also controlling the overall use of drugs from this class is unlikely to control outbreaks caused by the NAP1 strain of C. difficile.

Copyright
Corresponding author
Centers for Disease Control and Prevention, 1600 Clifton Road, MS A35, Atlanta, GA 30333 (cmcdonald1@cdc.gov)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. LC McDonald , M Owings , DB Jernigan . Increasing incidence of Clostridium difficile-associated disease in US short-stay hospitals, 1996-2003. Emerg Infect Dis 2006;12:409415.

3. L Eggertson , B Sibbald . Hospitals battling outbreaks of Clostridium difficile. CMAJ 2004;171:1921.

4. LC McDonald , GE Killgore , A Thompson , et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005;353:24332441.

5. M Warny , J Pepin , A Fang , et al. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet 2005;366:10791084.

6. R Gaynes , D Rimland , E Killum , et al. Outbreak of Clostridium difficile infection in a long-term care facility: association with gatifloxacin use. Clin Infect Dis 2004;38:640645.

10. WN Fawley , MH Wilcox . Pulsed-field gel electrophoresis can yield DNA fingerprints of degradation-susceptible Clostridium difficile strains. J Clin Microbiol 2002;40:35463547.

11. S Stubbs , M Rupnik , M Gibert , J Brazier , B Duerden , M Popoff . Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile. FEMS Microbiol Lett 2000;186:307312.

12. P Spigaglia , P Mastrantonio . Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates. J Clin Microbiol 2002;40:34703475.

14. A Elixhauser , C Steiner , DR Harris , RM Coffey . Comorbidity measures for use with administrative data. Med Care 1998;36:827.

15. DN Gerding , S Johnson , LR Peterson , ME Mulligan , J Silva Jr. Clostridium difficile-associated diarrhea and colitis. Infect Control Hosp Epidemiol 1995;16:459477.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 4 *
Loading metrics...

Abstract views

Total abstract views: 56 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 22nd July 2017. This data will be updated every 24 hours.