Skip to main content
    • Aa
    • Aa

Outbreak of Healthcare-Associated Infection and Colonization With Multidrug-Resistant Salmonella enterica Serovar Senftenberg in Florida

  • Robyn S. Kay (a1), Alexander G. Vandevelde (a2) (a3), Paul D. Fiorella (a4), Rebecca Crouse (a2) (a3), Carina Blackmore (a5), Roger Sanderson (a1), Christina L. Bailey (a2) (a3) and Michael L. Sands (a2) (a3)...

In July 1999, a rare strain of multidrug-resistant Salmonella enterica serovar Senftenberg was isolated from the sputum of a trauma patient. Over a 6-year period (1999-2005) in northeast Florida, this Salmonella serovar spread to 66 other patients in 16 different healthcare facilities as a result of frequent transfers of patients among institutions. To our knowledge, this is the first outbreak of healthcare-associated infection and colonization with a fluoroquinolone-resistant strain of S. Senftenberg in the United States.


To investigate an outbreak of infection and colonization with an unusual strain of S. Senftenberg and assist with infection control measures.


A case series, outbreak investigation, and microbiological study of all samples positive for S. Senftenberg on culture.


Cases of S. Senftenberg infection and colonization occurred in hospitals and long-term care facilities in 2 counties in northeast Florida.


The affected patients were mostly elderly persons with multiple medical conditions. They were frequently transferred between healthcare facilities. This Salmonella serovar was capable of long-term colonization of chronically ill patients. All S. Senftenberg isolates tested shared a similar pulsed-field gel electrophoresis (PFGE) pattern.


A prolonged outbreak of infection and colonization with multidrug-resistant S. Senftenberg was identified in several healthcare facilities throughout the Jacksonville, Florida, area and became established when infection control measures failed. The bacterial agent was capable of long-term colonization in chronically ill patients. Because the dispersal pattern of this strain suggested a breakdown of infection control practices, a multipronged intervention approach was undertaken that included intense education of personnel in the different institutions, interinstitutional cooperation, and transfer paperwork notification.

Corresponding author
Florida Department of Health, 1217 N. Pearl Street, Hardy Building 215, Jacksonville, FL 32202 (
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2. SJ Olsen , EE DeBess , TE McGivern , et al.A nosocomial outbreak of fluoroquinolone-resistant salmonella infections. N Engl J Med 2001;344:15721579.

10. JL Koeck , G Arlet , A Philippon , et al.A plasmid-mediated CMY-2 beta-lactamase from an Algerian clinical isolate of Salmonella senftenberg. FEMS Microbiol Lett 1997;152:255260.

12. AA Rushdy , JM Stuart , LR Ward , et al.National outbreak of Salmonella senftenberg associated with infant food. Epidemiol Infect 1998;120:125128.

13. PB L'Ecuyer , J Diego , D Murphy , et al.Nosocomial outbreak of gastroenteritis due to Salmonella senftenberg. Clin Infect Dis 1996;23:734742.

14. BV Navaneeth , R Tripathi , M Abbas , MR Belwadi . Subcutaneous abscess caused by extended-spectrum beta-lactamase-producing Salmonella senftenberg in a type 2 diabetic—a case report. Int f Infect Dis 2002;6:321322.

23. B Swaminathan , TJ Barrett , SB Hunter , et al.PulseNet: the molecular subtyping network for foodborne bacterial disease surveillance, United States. Emerg Infect Dis 2001;7:382389.

25. G Mehta , A Malik , S Singh , S Kumari . Asymptomatic Salmonella senftenberg carriage in a neonatal ward. J Hosp Infect 1992;22:317322.

28. D Nair , N Gupta , S Kabra , RB Ahuja , SK Prakash . Salmonella senftenberg: a new pathogen in the burns wards. Burns 1999;25:723727.

29. G Revathi , KP Shannon , PD Stapleton , BK Jain , GL French . An outbreak of extended-spectrum, beta-lactamase-producing Salmonella senftenberg in a burns ward. J Hosp Infect 1998;40:295302.

35. H Herikstad , P Hayes , M Mokhtar , ML Fracaro , EJ Threlfall , FJ Angulo . Emerging quinolone-resistant Salmonella in the United States. Emerg Infect Dis 1997;3:371372.

36. K Molbak , DL Baggesen , FM Aaresrup , et al.An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype Typhimurium DT104. N Engl J Med 1999;341:14201425.

37. CH Chiu , TL Wu , LH Su , et al.The emergence in Taiwan of fluoroquinolone resistance in Salmonella enterica serotype Choleraesuis. NEngl J Med 2002;346:413419.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 4 *
Loading metrics...

Abstract views

Total abstract views: 30 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 28th May 2017. This data will be updated every 24 hours.