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Preventing Nosocomial Influenza by Improving the Vaccine Acceptance Rate of Clinicians

  • Cassandra D. Salgado (a1), Eve T. Giannetta (a2), Frederick G. Hayden (a2) and Barry M. Farr (a2)



To assess the effects of interventions to prevent transmission of influenza and to increase employee compliance with influenza vaccination.


The change in the proportion of hospitalized patients with laboratory-confirmed nosocomial influenza was observed over time and assessed using chi-square for trend analysis. The association between nosocomial influenza in patients and healthcare worker (HCW) compliance with vaccine was assessed by logistic regression.


A 600-bed, tertiary-care academic hospital.


After an outbreak of influenza A at this hospital in 1988, a mobile cart program was instituted with increased efforts to motivate employees to be vaccinated and furloughed when ill as well as new measures to prevent nosocomial spread.


HCW vaccination rates increased from 4% in 1987–1988 to 67% in 1999–2000 (P < .0001). Proportions of nosocomially acquired influenza cases among employees or patients both declined significantly (P < .0001). Logistic regression analysis revealed a significant inverse association between HCW compliance with vaccination and the rate of nosocomial influenza among patients (P < .001).


A mobile cart vaccination program and an increased emphasis on HCWs to receive the vaccine were associated with a significant increase in vaccine acceptance and a significant decrease in the rate of nosocomial influenza among patients.


Corresponding author

Hospital Epidemiologist, Medical University of South Carolina, 100 Doughty Street, Suite 210 BA/IOP, Charleston, SC 29425


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