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Strategies to Prevent Methicillin-Resistant Staphylococcus aureus Transmission and Infection in Acute Care Hospitals: 2014 Update

  • David P. Calfee (a1), Cassandra D. Salgado (a2), Aaron M. Milstone (a3), Anthony D. Harris (a4), David T. Kuhar (a5), Julia Moody (a6), Kathy Aureden (a7), Susan S. Huang (a8), Lisa L. Maragakis (a3) and Deborah S. Yokoe (a9)...
Abstract

Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections (HAIs). The intent of this document is to highlight practical recommendations in a concise format designed to assist acute care hospitals in implementing and prioritizing their methicillin-resistant Staphylococcus aureus (MRSA) prevention efforts. This document updates “Strategies to Prevent Transmission of Methicillin-Resistant Staphylococcus aureus in Acute Care Hospitals,” published in 2008. This expert guidance document is sponsored by the Society for Healthcare Epidemiology of America (SHEA) and is the product of a collaborative effort led by SHEA, the Infectious Diseases Society of America (IDSA), the American Hospital Association (AHA), the Association for Professionals in Infection Control and Epidemiology (APIC), and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise. The list of endorsing and supporting organizations is presented in the introduction to the 2014 updates.

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References
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1.Calfee DP, Salgado CD, Classen D, et al. Strategies to prevent transmission of methicillin-resistant Staphylococcus aureus in acute care hospitals. Infect Control Hosp Epidemiol 2008;29(suppl 1):S62S80.
2.Yokoe DS, Anderson DJ, Berenholtz SM, et al. Introduction to “A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals: 2014 Updates.” Infect Control Hosp Epidemiol 2014;35(5):455459.
3.Sievert DM, Ricks P, Edwards JR, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010. Infect Control Hosp Epidemiol 2013;34:114.
4.Hidron AI, Edwards JR, Patel J, et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008;29:9961011.
5.Kallen AJ, Mu Y, Bulens S, et al. Health care-associated invasive MRSA infections, 2005-2008. JAMA 2010;304:641648.
6.Dantes R, Mu Y, Belflower R, et al. National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011. JAMA Intern Med 2013;173(21):19701978.
7.Iwamoto M, Mu Y, Lynfield R, et al. Trends in invasive methicillin-resistant Staphylococcus aureus infections. Pediatrics 2013;132:e817e824.
8.Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW, Carmeli Y.Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 2003; 36:5359.
9.Engemann JJ, Carmeli Y, Cosgrove SE, et al. Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection. Clin Infect Dis 2003;36:592598.
10.Abramson MA, Sexton DJ. Nosocomial methicillin-resistant and methicillin-susceptible Staphylococcus aureus primary bacteremia: at what costs? Infect Control Hosp Epidemiol 1999;20: 408411.
11.McHugh CG, Riley LW. Risk factors and costs associated with methicillin-resistant Staphylococcus aureus bloodstream infections. Infect Control Hosp Epidemiol 2004;25:425430.
12.Harbarth S, Rutschmann O, Sudre P, Pittet D.Impact of methicillin resistance on the outcome of patients with bacteremia caused by Staphylococcus aureus. Arch Intern Med 1998;158: 182189.
13.Cosgrove SE, Qi Y, Kaye KS, Harbarth S, Karchmer AW, Carmeli Y.The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges. Infect Control Hosp Epidemiol 2005; 26:166174.
14.Huang SS, Platt R.Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization. Clin Infect Dis 2003;36:281285.
15.Garrouste-Orgeas M, Timsit JF, Kallel H, et al. Colonization with methicillin-resistant Staphylococcus aureus in ICU patients: morbidity, mortality, and glycopeptide use. Infect Control Hosp Epidemiol 2001;22:687692.
16.Freitas EA, Harris RM, Blake RK, Salgado CD. Prevalence of USA300 strain type of methicillin-resistant Staphylococcus aureus among patients with nasal colonization identified with active surveillance. Infect Control Hosp Epidemiol 2010;31:469475.
17.Huang SS, Hinrichsen VL, Datta R, et al. Methicillin-resistant Staphylococcus aureus infection and hospitalization in high-risk patients in the year following detection. PLoS ONE 2011;6: e24340.
18.Datta R, Huang SS. Risk of infection and death due to methicillin-resistant Staphylococcus aureus in long-term carriers. Clin Infect Dis 2008;47:176181.
19.Milstone AM, Goldner BW, Ross T, Shepard JW, Carroll KC, Perl TM. Methicillin-resistant Staphylococcus aureus colonization and risk of subsequent infection in critically ill children: importance of preventing nosocomial methicillin-resistant Staphylococcus aureus transmission. Clin Infect Dis 2011;53: 853859.
20.Merrer J, Santoli F, Appere de Vecchi C, Tran B, De Jonghe B, Outin H.“Colonization pressure” and risk of acquisition of methicillin-resistant Staphylococcus aureus in a medical intensive care unit. Infect Control Hosp Epidemiol 2000;21:718723.
21.Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med 2006;355:666674.
22.King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, Blumberg HM. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med 2006;144:309317.
23.Maree CL, Daum RS, Boyle-Vavra S, Matayoshi K, Miller LG. Community-associated methicillin-resistant Staphylococcus aureus isolates causing healthcare-associated infections. Emerg Infect Dis 2007;13:236242.
24.Klevens RM, Morrison MA, Nadle J, et al. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 2007;298:17631771.
25.Popovich KJ, Weinstein RA, Hota B.Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains? Clin Infect Dis 2008;46:787794.
26.Jenkins TC, McCollister BD, Sharma R, et al. Epidemiology of healthcare-associated bloodstream infection caused by USA300 strains of methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals. Infect Control Hosp Epidemiol 2009;30:233241.
27.Park SH, Park C, Yoo JH, et al. Emergence of community-associated methicillin-resistant Staphylococcus aureus strains as a cause of healthcare-associated bloodstream infections in Korea. Infect Control Hosp Epidemiol 2009;30:146155.
28.Carey AJ, Delia-Latta P, Huard R, et al. Changes in the molecular epidemiological characteristics of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2010;31:613619.
29.Milstone AM, Carroll KC, Ross T, Shangraw KA, Perl TM. Community-associated methicillin-resistant Staphylococcus aureus strains in pediatric intensive care unit. Emerg Infect Dis 2010;16:647655.
30.Lessa FC, Mu Y, Ray SM, et al. Impact of USA300 methicillin-resistant Staphylococcus aureus on clinical outcomes of patients with pneumonia or central line-associated bloodstream infections. Clin Infect Dis 2012;55:232241.
31.Bhalla A, Pultz NJ, Gries DM, et al. Acquisition of nosocomial pathogens on hands after contact with environmental surfaces near hospitalized patients. Infect Control Hosp Epidemiol 2004; 25:164167.
32.Smith MA, Mathewson JJ, Ulert IA, Scerpella EG, Ericsson CD. Contaminated stethoscopes revisited. Arch Intern Med 1996; 156:8284.
33.Cohen HA, Liora H, Paret G.Aurioscope earpieces—a potential vector of infection? Int J Pediatr Otorhinolaryngol 1998;45: 4750.
34.Bernard L, Kereveur A, Durand D, et al. Bacterial contamination of hospital physicians’ stethoscopes. Infect Control Hosp Epidemiol 1999;20:626628.
35.Embil JM, McLeod JA, Al-Barrak AM, et al. An outbreak of methicillin resistant Staphylococcus aureus on a burn unit: potential role of contaminated hydrotherapy equipment. Burns 2001;27:681688.
36.Breathnach AS, Jenkins DR, Pedler SJ. Stethoscopes as possible vectors of infection by staphylococci. BMJ 1992;305:15731574.
37.Boyce JM, Potter-Bynoe G, Chenevert C, King T.Environmental contamination due to methicillin-resistant Staphylococcus aureus: possible infection control implications. Infect Control Hosp Epidemiol 1997;18:622627.
38.Sexton T, Clarke P, O’Neill E, Dillane T, Humphreys H.Environmental reservoirs of methicillin-resistant Staphylococcus aureus in isolation rooms: correlation with patient isolates and implications for hospital hygiene. J Hosp Infect 2006;62:187194.
39.Weber DJ, Anderson D, Rutala WA. The role of the surface environment in healthcare-associated infections. Curr Opin Infect Dis 2013;26:338344.
40.Weber DJ, Rutala WA. Understanding and preventing transmission of healthcare-associated pathogens due to the contaminated hospital environment. Infect Control Hosp Epidemiol 2013;34:449452.
41.Huang SS, Datta R, Platt R.Risk of acquiring antibiotic-resistant bacteria from prior room occupants. Arch Intern Med 2006;166:19451951.
42.National Healthcare Safety Network. Multidrug-Resistant Organism and Clostridium difficile Infection (MDRO/CDI) Module. 2014. http://www.cdc.gov/nhsn/PDFs/pscManual/12pscMDRO_CDADcurrent.pdf. Accessed March 11, 2014.
43.National Healthcare Safety Network. CDC/NHSN Surveillance Definition of Healthcare-Associated Infection and Criteria for Specific Types of Infections in the Acute Care Setting. 2014. http://www.cdc.gov/nhsn/PDFs/pscManual/17pscNosInfDef_current.pdf. Accessed March 11, 2014.
44.Cohen AL, Calfee D, Fridkin SK, et al. Recommendations for metrics for multidrug-resistant organisms in healthcare settings: SHEA/HICPAC position paper. Infect Control Hosp Epidemiol 2008;29:901913.
45.Siegel JD, Rhinehart E, Jackson M, Chiarello L.Management of multidrug-resistant organisms in health care settings, 2006. Am J Infect Control 2007;35:S165S193.
46.Coia JE, Duckworth GJ, Edwards DI, et al. Guidelines for the control and prevention of methicillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities. } Hosp Infect 2006; 63(suppl 1):S1S44.
47.Infection Prevention Working Party. MRSA in Hospitals. 2012. http://www.wip.n1/UK/free_content/Richtlijnen/l10530%20MRSA%20hospital%20def.pdf. Accessed June 4, 2013.
48.Dutch Working Party on Antibiotic Policy. Optimalization of the Antibiotic Policy in the Netherlands XI: Revision Swab Guideline for the Treatment of MRSA Carriage. 2012. http://www.swab.nl/swab/cms3.nsf/uploads/51DB72E670CAC33BC12579BF00342A95/$FILE/SwabrichtlijnMRSAherziening%2015022012_EN.pdf. Accessed June 4, 2013.
49.Institute for Healthcare Improvement. How to Guide: Reduce MRSA Infection. 2011.
50.Association for Professionals in Infection Control and Epidemiology. Guide to the Elimination of Methicillin-Resistant Staohylococcus aureus (MRSA) Transmission in Hospital Settings. 2nd ed. 2010.
51.Johnson PD, Martin R, Burrell LJ, et al. Efficacy of an alcohol/chlorhexidine hand hygiene program in a hospital with high rates of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection. Med J Aust 2005;183:509514.
52.Gopal Rao G, Jeanes A, Osman M, Aylott C, Green J.Marketing hand hygiene in hospitals—a case study, J Hosp Infect 2002; 50:4247.
53.Morgan DJ, Rogawski E, Thorn KA, et al. Transfer of multidrug-resistant bacteria to healthcare workers’ gloves and gowns after patient contact increases with environmental contamination. Crit Care Med 2012;40:10451051.
54.Chang S, Sethi AK, Stiefel U, Cadnum JL, Donskey CJ. Occurrence of skin and environmental contamination with methicillin-resistant Staphylococcus aureus before results of poly-merase chain reaction at hospital admission become available. Infect Control Hosp Epidemiol 2010;31:607612.
55.Siegel JD, Rhinehart E, Jackson M, Chiarello L.2007 Guideline for isolation precautions: preventing transmission of infectious agents in health care settings. Am J Infect Control. 2007;35:S65S164.
56.Scanvic A, Denic L, Gaillon S, Giry P, Andremont A, Lucet JC. Duration of colonization by methicillin-resistant Staphylococcus aureus after hospital discharge and risk factors for prolonged carriage. Clin Infect Dis 2001;32:13931398.
57.Sanford MD, Widmer AR, Bale MJ, Jones RN, Wenzel RP. Efficient detection and long-term persistence of the carriage of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 1994; 19:11231128.
58.Kirkland KB, Weinstein JM. Adverse effects of contact isolation. Lancet 1999;354:11771178.
59.Saint S, Higgins LA, Nallamothu BK, Chenoweth C.Do physicians examine patients in contact isolation less frequently? a brief report. Am J Infect Control 2003;31:354356.
60.Evans HL, Shaffer MM, Hughes MG, et al. Contact isolation in surgical patients: a barrier to care? Surgery 2003; 134:180188.
61.Catalano G, Houston SH, Catalano MC, et al. Anxiety and depression in hospitalized patients in resistant organism isolation. South Med J 2003;96:141145.
62.Day HR, Perencevich EN, Harris AD, et al. Do contact precautions cause depression? a two-year study at a tertiary care medical centre. J Hosp Infect 2011;79:103107.
63.Stelfox HT, Bates DW, Redelmeier DA. Safety of patients isolated for infection control. JAMA 2003;290:18991905.
64.Harris AD, Pineles L, Belton B, et al. Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial. JAMA 2013;310:15711580.
65.Diekema DJ, Edmond MB. Look before you leap: active surveillance for multidrug-resistant organisms. Clin Infect Dis 2007;44:11011107.
66.Hardy KJ, Oppenheim BA, Gossain S, Gao F, Hawkey PM. A study of the relationship between environmental contamination with methicillin-resistant Staphylococcus aureus (MRSA) and patients’ acquisition of MRSA. Infect Control Hosp Epidemiol 2006;27:127132.
67.French GL, Otter JA, Shannon KP, Adams NM, Watling D, Parks MJ. Tackling contamination of the hospital environment by methicillin-resistant Staphylococcus aureus (MRSA): a comparison between conventional terminal cleaning and hydrogen peroxide vapour decontamination. J Hosp Infect 2004;57:3137.
68.Oie S, Hosokawa I, Kamiya A.Contamination of room door handles by methicillin-sensitive/methicillin-resistant Staphylococcus aureus. J Hosp Infect 2002;51:140143.
69.Rampling A, Wiseman S, Davis L, et al. Evidence that hospital hygiene is important in the control of methicillin-resistant Staphylococcus aureus. J Hosp Infect 2001;49:109116.
70.Vajravelu RK, Guerrero DM, Jury LA, Donskey CJ. Evaluation of stethoscopes as vectors of Clostridium difficile and methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol 2012;33:9698.
71.Carling P.Methods for assessing the adequacy of practice and improving room disinfection. Am J Infect Control 2013;41:S20S25.
72.Dancer SJ. Importance of the environment in meticillin-resistant Staphylococcus aureus acquisition: the case for hospital cleaning. Lancet Infect Dis 2008;8:101113.
73.Carling PC, Parry MF, Bruno-Murtha LA, Dick B.Improving environmental hygiene in 27 intensive care units to decrease multidrug-resistant bacterial transmission. Crit Care Med 2010; 38:10541059.
74.Abad C, Fearday A, Safdar N.Adverse effects of isolation in hospitalised patients: a systematic review. J Hosp Infect 2010; 76:97102.
75.Salgado CD, Farr BM. What proportion of hospital patients colonized with methicillin-resistant Staphylococcus aureus are identified by clinical microbiological cultures? Infect Control Hosp Epidemiol 2006;27:116121.
76.Huang SS, Rifas-Shiman SL, Warren DK, et al. Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care units. J Infect Dis 2007;195:330338.
77.Jain R, Krsalovic SM, Evans ME, et al. Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections. N Engl J Med 2011;364:14191430.
78.West TE, Guerry C, Hiott M, Morrow N, Ward K, Salgado CD. Effect of targeted surveillance for control of methicillin-resistant Staphylococcus aureus in a community hospital system. Infect Control Hosp Epidemiol 2006;27:233238.
79.Huang SS, Yokoe DS, Hinrichsen VL, et al. Impact of routine intensive care unit surveillance cultures and resultant barrier precautions on hospital-wide methicillin-resistant Staphylococcus aureus bacteremia. Clin Infect Dis 2006;43:971978.
80.Lucet JC, Paoletti X, Lolom I, et al. Successful long-term program for controlling methicillin-resistant Staphylococcus aureus in intensive care units. Intensive Care Med 2005;31:10511057.
81.Marshall C, Richards M, McBryde E.Do active surveillance and contact precautions reduce MRSA acquisition? a prospective interrupted time series. PLoS ONE 2013;8:e58112.
82.Perlin JB, Hickok JD, Septimus EJ, Moody JA, Englebright JD, Bracken RM. A bundled approach to reduce methicillin-resistant Staphylococcus aureus infections in a system of community hospitals. J Healthc Qual 2013;35:5768.
83.Harbarth S, Fankhauser C, Schrenzel J, et al. Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA 2008;299:11491157.
84.Huskins WC, Huckabee CM, O’Grady NP, et al. Intervention to reduce transmission of resistant bacteria in intensive care. N Engl J Med 2011;364:14071418.
85.Agency for Healthcare Quality Research. Screening for Methi-cillin-Resistant Staphylococcus aureus (MRSA). 2013. http://www.effectivehealthcare.ahrq.gov/ehc/products/228/1550/MRSA-screening-report-130617.pdf. Accessed July 18, 2013.
86.Gurieva TV, Bootsma MC, Bonten MJ. Decolonization of patients and health care workers to control nosocomial spread of methicillin-resistant Staphylococcus aureus: a simulation study. BMC Infect Dis 2012;12:302.
87.Miller MA, Dascal A, Portnoy J, Mendelson J.Development of mupirocin resistance among methicillin-resistant Staphylococcus aureus after widespread use of nasal mupirocin ointment. Infect Control Hosp Epidemiol 1996;17:811813.
88.Lepainteur M, Royer G, Bourrel AS, et al. Prevalence of resistance to antiseptics and mupirocin among invasive coagulase-negative staphylococci from very preterm neonates in NICU: the creeping threat? J Hosp Infect 2013;83:333336.
89.Teo BW, Low SJ, Ding Y, Koh TH, Hsu LY. High prevalence of mupirocin-resistant staphylococci in a dialysis unit where mupirocin and chlorhexidine are routinely used for prevention of catheter-related infections. J Med Microbiol 2011;60:865867.
90.Ridenour G, Lampen R, Federspiel J, Kritchevsky S, Wong E, Climo M.Selective use of intranasal mupirocin and chlorhexidine bathing and the incidence of methicillin-resistant Staphylococcus aureus colonization and infection among intensive care unit patients. Infect Control Hosp Epidemiol 2007;28:11551161.
91.Saiman L, Cronquist A, Wu F, et al. An outbreak of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2003;24:317321.
92.Nambiar S, Herwaldt LA, Singh N.Outbreak of invasive disease caused by methicillin-resistant Staphylococcus aureus in neonates and prevalence in the neonatal intensive care unit. Pediatr Crit Care Med 2003;4:220226.
93.Hitomi S, Kubota M, Mori N, et al. Control of a methicillin-resistant Staphylococcus aureus outbreak in a neonatal intensive care unit by unselective use of nasal mupirocin ointment. J Hosp Infect 2000;46:123129.
94.Herwaldt LA. Reduction of Staphylococcus aureus nasal carriage and infection in dialysis patients. J Hosp Infect 1998;40(suppl B):S13S23.
95.Miller LG, Eells SJ, Taylor AR, et al. Staphylococcus aureus colonization among household contacts of patients with skin infections: risk factors, strain discordance, and complex ecology. Clin Infect Dis 2012;54:15231535.
96.Kluytmans JA, Mouton JW, VandenBergh MF, et al. Reduction of surgical-site infections in cardiothoracic surgery by elimination of nasal carriage of Staphylococcus aureus. Infect Control Hosp Epidemiol 1996;17:780785.
97.Pofahl WE, Goettler CE, Ramsey KM, Cochran MK, Nobles DL, Rotondo MEActive surveillance screening of MRSA and eradication of the carrier state decreases surgical-site infections caused by MRSA. J Am Coll Surg 2009;208:981986.
98.Wilcox MH, Hall J, Pike H, et al. Use of perioperative mupirocin to prevent methicillin-resistant Staphylococcus aureus (MRSA) orthopaedic surgical site infections. J Hosp Infect 2003; 54:196201.
99.Schweizer M, Perencevich E, McDanel J, et al. Effectiveness of a bundled intervention of decolonization and prophylaxis to decrease gram positive surgical site infections after cardiac or orthopedic surgery: systematic review and meta-analysis. BMJ 2013;346:f2743.
100.Anderson DJ, Podgorny K, Berríos-Torres SI, et al. Strategies to prevent surgical site infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol 2014;35(6):605627.
101.Vernon MO, Hayden MK, Trick WE, Hayes RA, Blom DW, Weinstein RA. Chlorhexidine gluconate to cleanse patients in a medical intensive care unit: the effectiveness of source control to reduce the bioburden of vancomycin-resistant enterococci. Arch Intern Med 2006;166:306312.
102.Munoz-Price LS, Hota B, Sterner A, Weinstein RA. Prevention of bloodstream infections by use of daily chlorhexidine baths for patients at a long-term acute care hospital. Infect Control Hosp Epidemiol 2009;30:10311035.
103.Evans HL, Dellit TH, Chan J, Nathens AB, Maier RV, Cuschieri J.Effect of chlorhexidine whole-body bathing on hospital-acquired infections among trauma patients. Arch Surg 2010; 145:240246.
104.Popovich KJ, Hota B, Hayes R, Weinstein RA, Hayden MK. Effectiveness of routine patient cleansing with chlorhexidine gluconate for infection prevention in the medical intensive care unit. Infect Control Hosp Epidemiol 2009;30:959963.
105.Climo MW, Yokoe DS, Warren DK, et al. Effect of daily chlorhexidine bathing on hospital-acquired infection. N Engl J Med 2013;368:533542.
106.Huang SS, Septimus E, Kleinman K, et al. Targeted versus universal decolonization to prevent ICU infection. N Engl J Med 2013;368:22552265.
107.Milstone AM, Elward A, Song X, et al. Daily chlorhexidine bathing to reduce bacteraemia in critically ill children: a mul-ticentre, cluster-randomised, crossover trial. Lancet 2013;381: 10991106.
108.Climo MW, Sepkowitz KA, Zuccotti G, et al. The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Entero-coccus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial. Crit Care Med 2009;37:18581865.
109.Marschall J, Mermel LA, Fakih M, et al. Strategies to prevent central line-associated bloodstream infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol 2014; 35(7):753771 (in this issue).
110.Karki S, Cheng AC. Impact of non-rinse skin cleansing with chlorhexidine gluconate on prevention of healthcare-associated infections and colonization with multi-resistant organisms: a systematic review. J Hosp Infect 2012;82:7184.
111.Derde LP, Cooper BS, Goossens H, et al. Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and cluster randomised trial. Lancet Infect Dis 2013;14(1):319.
112.Rupp ME, Cavalieri RJ, Lyden E, et al. Effect of hospital-wide chlorhexidine patient bathing on healthcare-associated infections. Infect Control Hosp Epidemiol 2012;33:10941100.
113.Delaney HM, Wang E, Melish M.Comprehensive strategy including prophylactic mupirocin to reduce Staphylococcus aureus colonization and infection in high-risk neonates. J Perinatol 2013;33:313318.
114.Fritz SA, Hogan PG, Hayek G, et al. Staphylococcus aureus colonization in children with community-associated Staphylococcus aureus skin infections and their household contacts. Arch Pediatr Adolesc Med 2012;166:551557.
115.Clinical and Laboratory Standards Institute (CLSI). Performance Standards f or Antimicrobial Susceptibility Testing: Twenty-Third Informational Supplement. Wayne, PA: CLSI, 2013. CLSI document M100-S23.
116.Center for Medicare & Medicaid Services. Federal Register. 2012. http://www.gpo.gov/fdsys/pkg/FR-2012-05-ll/pdf/2012-9985.pdf. Accessed July 18, 2013.
117.The Joint Commission. National Patient Safety Goals. 2013. http://www.jointcommission.org/standards_information/npsgs.aspx. Accessed July 18, 2013.
118.Center for Medicare & Medicaid Services. State Operations Manual: Appendix A—Survey Protocol, Regulations and Interpretive Guidelines for Hospitals. Rev. 84, 06-07-13. 2013. http://www.cms.gov/Regulations-and-Guidance/Guidance/Manuals/downloads/soml07ap_a_hospitals.pdf. Accessed July 18, 2013.
119.Ellingson K, Hass JP, Aiello AE, et al. Strategies to prevent healthcare-associated infections through hand hygiene. Infect Control Hosp Epidemiol 2014 (forthcoming).
120.Seto WH. Training the work force—models for effective education in infection control. J Hosp Infect 1995;30(suppl):241247.
121.Sehulster L, Chinn RY. Guidelines for environmental infection control in health-care facilities: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC). MMWR Recomm Rep 2003;52:142.
122.Rutala WA, Weber DJ; Healthcare Infection Control Practices Advisory Committee (HICPAC). Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008. http://www.cdc.gov/hicpac/pdf/guidelines/Disinfection_Nov_2008.pdf. Accessed July 18, 2013.
123.Otter JA, Yezli S, Perl TM, Barbut F, French GL. The role of “no-touch” automated room disinfection systems in infection prevention and control. J Hosp Infect 2013;83:113.
124.Passaretti CL, Otter JA, Reich NG, et al. An evaluation of environmental decontamination with hydrogen peroxide vapor for reducing the risk of patient acquisition of multidrug-resistant organisms. Clin Infect Dis 2013;56:2735.
125.Salgado CD, Sepkowitz KA, John JF, et al. Copper surfaces reduce the rate of healthcare-acquired infections in the intensive care unit. Infect Control Hosp Epidemiol 2013;34:479486.
126.Kac G, Grohs P, Durieux P, et al. Impact of electronic alerts on isolation precautions for patients with multidrug-resistant bacteria. Arch Intern Med 2007;167:20862090.
127.Halpin H, Shortell SM, Milstein A, Vanneman M.Hospital adoption of automated surveillance technology and the implementation of infection prevention and control programs. Am J Infect Control 2011;39:270276.
128.Wright MO. Automated surveillance and infection control: toward a better tomorrow. Am J Infect Control 2008;36:S1S6.
129.Mozzillo KL, Ortiz N, Miller LG. Patients with methicillin-resistant Staphylococcus aureus infection: twenty-first century lepers. J Hosp Infect 2010;75:132134.
130.Briggs JJ, Milstone AM. Changes over time in caregivers’ knowledge, attitudes, and behaviors regarding methicillin-resistant Staphylococcus aureus. J Pediatr 2011;158:1039.
131.Wang JT, Chang SC, Ko WJ, et al. A hospital-acquired outbreak of methicillin-resistant Staphylococcus aureus infection initiated by a surgeon carrier, J Hosp Infect 2001;47:104109.
132.Faibis F, Laporte C, Fiacre A, et al. An outbreak of methicillin-resistant Staphylococcus aureus surgical-site infections initiated by a healthcare worker with chronic sinusitis. Infect Control Hosp Epidemiol 2005;26:213215.
133.Coombs GW, Van Gessel H, Pearson JC, Godsell MR, O’Brien FG, Christiansen KJ. Controlling a multicenter outbreak involving the New York/Japan methicillin-resistant Staphylococcus aureus clone. Infect Control Hosp Epidemiol 2007;28:845852.
134.Pittet D, Allegranzi B, Sax H, Dharan S, Pessoa-Silva CL, Donaldson L, Boyce JM. Evidence-based model for hand transmission during patient care and the role of improved practices. Lancet Infect Dis 2006;6:641652.
135.Thompson RL, Cabezudo I, Wenzel RP. Epidemiology of nosocomial infections caused by methicillin-resistant Staphylococcus aureus. Ann Intern Med 1982;97:309317.
136.Cox RA, Conquest C.Strategies for the management of healthcare staff colonized with epidemic methicillin-resistant Staphylococcus aureus. J Hosp Infect 1997;35:117127.
137.Albrich WC, Harbarth S.Health-care workers: source, vector, or victim of MRSA? Lancet Infect Dis 2008;8:289301.
138.Cookson B, Peters B, Webster M, Phillips I, Rahman M, Noble W.Staff carriage of epidemic methicillin-resistant Staphylococcus aureus. J Clin Microbiol 1989;27:14711476.
139.Bertin ML, Vinski J, Schmitt S, et al. Outbreak of methicillin-resistant Staphylococcus aureus colonization and infection in a neonatal intensive care unit epidemiologically linked to a healthcare worker with chronic otitis. Infect Control Hosp Epidemiol 2006;27:581585.
140.Stein M, Navon-Venezia S, Chmelnitsky I, et al. An outbreak of new, nonmultidrug-resistant, methicillin-resistant Staphylococcus aureus strain (SCCmec type IILA variant-1 ) in the neonatal intensive care unit transmitted by a staff member. Pediatr Infect Dis J 2006;25:557559.
141.Meier PA, Carter CD, Wallace SE, Hollis RJ, Pfaller MA, Herwaldt LA. A prolonged outbreak of methicillin-resistant Staphylococcus aureus in the burn unit of a tertiary medical center. Infect Control Hosp Epidemiol 1996;17:798802.
142.Blok HE, Troelstra A, Kamp-Hopmans TE, et al. Role of healthcare workers in outbreaks of methicillin-resistant Staphylococcus aureus: a 10-year evaluation from a Dutch university hospital. Infect Control Hosp Epidemiol 2003;24:679685.
143.Wendt C, Schinke S, Wurttemberger M, Oberdorfer K, Hensley O, von Baum H.Value of whole-body washing with chlorhexidine for the eradication of methicillin-resistant Staphylococcus aureus: a randomized, placebo-controlled, double-blind clinical trial. Infect Control Hosp Epidemiol 2007;28:10361043.
144.Popovich KJ, Lyles R, Hayes R, et al. Relationship between chlorhexidine gluconate skin concentration and microbial density on the skin of critically ill patients bathed daily with chlorhexidine gluconate. Infect Control Hosp Epidemiol 2012;33:889896.
145.Tamma PD, Aucott SW, Milstone AM. Chlorhexidine use in the neonatal intensive care unit: results from a national survey. Infect Control Hosp Epidemiol 2010;31:846849.
146.Chapman AK, Aucott SW, Milstone AM. Safety of chlorhexidine gluconate used for skin antisepsis in the preterm infant. J Perinatol 2012;32:49.
147.Sitzlar B, Deshpande A, Fertelli D, Kundrapu S, Sethi AK, Donskey CJ. An environmental disinfection Odyssey: evaluation of sequential interventions to improve disinfection of Clostridium difficile isolation rooms. Infect Control Hosp Epidemiol 2013;34:459465.
148.Carling PC, Parry MF, Von Beheren SM. Identifying opportunities to enhance environmental cleaning in 23 acute care hospitals. Infect Control Hosp Epidemiol 2008;29:17.
149.Morgan DJ, Day HR, Furano JP, et al. Improving efficiency in active surveillance for methicillin-resistant Staphylococcus aureus or vancomycin-resistant Enterococcus at hospital admission. Infect Control Hosp Epidemiol 2010;31:12301235.
150.Reilly JS, Stewart S, Christie P, et al. Universal screening for meticillin-resistant Staphylococcus aureus in acute care: risk factors and outcome from a multicentre study. J Hosp Infect 2012; 80:3135.
151.Haley CC, Mittal D, Laviolette A, Jannapureddy S, Parvez N, Haley RW. Methicillin-resistant Staphylococcus aureus infection or colonization present at hospital admission: multivariable risk factor screening to increase efficiency of surveillance culturing. J Clin Microbiol 2007;45:30313038.
152.Riedel S, Von Stein D, Richardson K, et al. Development of a prediction rule for methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus carriage in a Veterans Affairs medical center population. Infect Control Hosp Epidemiol 2008;29:969971.
153.Harbarth S, Sax H, Fankhauser-Rodriguez C, Schrenzel J, Agostinho A, Pittet D.Evaluating the probability of previously unknown carriage of MRSA at hospital admission. Am J Med 2006; 119:275.e215-275.e223.
154.Lautenbach E, Nachamkin I, Hu B, et al. Surveillance cultures for detection of methicillin-resistant Staphylococcus aureus: diagnostic yield of anatomic sites and comparison of provider-and patient-collected samples. Infect Control Hosp Epidemiol 2009;30:380382.
155.Furuno JP, Harris AD, Wright MO, et al. Value of performing active surveillance cultures on intensive care unit discharge for detection of methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol 2007;28:666670.
156.Senn L, Basset P, Nahimana I, Zanetti G, Blanc DS. Which anatomical sites should be sampled for screening of methicillin-resistant Staphylococcus aureus carriage by culture or by rapid PCR test? Clin Micro Infect 2012;18:E31-E33.
157.McKinnell JA, Huang SS, Eells SJ, Cui E, Miller LG. Quantifying the impact of extranasal testing of body sites for methicillin-resistant Staphylococcus aureus colonization at the time of hospital or intensive care unit admission. Infect Control Hosp Epidemiol 2013;34:161170.
158.Shurland SM, Stine OC, Venezia RA, et al. Colonization sites of USA300 methicillin-resistant Staphylococcus aureus in residents of extended care facilities. Infect Control Hosp Epidemiol 2009;30:313318.
159.Matheson A, Christie P, Stari T, et al. Nasal swab screening for methicillin-resistant Staphylococcus aureus—how well does it perform? a cross-sectional study. Infect Control Hosp Epidemiol 2012;33:803808.
160.Eveillard M, de Lassence A, Lancien E, Barnaud G, Ricard JD, Joly-Guillou ML. Evaluation of a strategy of screening multiple anatomical sites for methicillin-resistant Staphylococcus aureus at admission to a teaching hospital. Infect Control Hosp Epidemiol 2006;27:181184.
161.Popovich KJ, Hota B, Aroutcheva A, et al. Community-associated methicillin-resistant Staphylococcus aureus colonization burden in HIV-infected patients. Clin Infect Dis 2013;56:10671074.
162.Gerber SI, Jones RC, Scott MV, et al. Management of outbreaks of methicillin-resistant Staphylococcus aureus infection in the neonatal intensive care unit: a consensus statement. Infect Control Hosp Epidemiol 2006;27:139145.
163.Rosenthal A, White D, Churilla S, Brodie S, Katz KC. Optimal surveillance culture sites for detection of methicillin-resistant Staphylococcus aureus in newborns. J Clin Microbiol 2006;44: 42344236.
164.Bishop EJ, Grabsch EA, Ballard SA, et al. Concurrent analysis of nose and groin swab specimens by the IDI-MRSA PCR assay is comparable to analysis by individual-specimen PCR and routine culture assays for detection of colonization by methicillin-resistant Staphylococcus aureus. J Clin Microbiol 2006;44:29042908.
165.Diederen B, van Duijn I, van Belkum A, Willemse P, van Keulen P, Kluytmans J.Performance of CHROMagar MRSA medium for detection of methicillin-resistant Staphylococcus aureus. J Clin Microbiol 2005;43:19251927.
166.Diederen BM, van Leest ML, van Duijn I, Willemse P, van Keulen PH, Kluytmans JA. Performance of MRSA ID, a new chromogenie medium for detection of methicillin-resistant Staphylococcus aureus. J Clin Microbiol 2006;44:586588.
167.Flayhart D, Hindler JF, Bruckner DA, et al. Multicenter evaluation of BBL CHROMagar MRSA medium for direct detection of methicillin-resistant Staphylococcus aureus from surveillance cultures of the anterior nares. J Clin Microbiol 2005;43:55365540.
168.Stoakes L, Reyes R, Daniel J, et al. Prospective comparison of a new chromogenie medium, MRSAselect, to CHROMagar MRSA and mannitol-salt medium supplemented with oxacillin or cefoxitin for detection of methicillin-resistant Staphylococcus aureus. J Clin Microbiol 2006;44:637639.
169.Han Z, Lautenbach E, Fishman N, Nachamkin I.Evaluation of mannitol salt agar, CHROMagar Staph aureus and CHROMagar MRSA for detection of meticillin-resistant Staphylococcus aureus from nasal swab specimens. J Clin Microbiol 2007;56:4346.
170.Wassenberg MW, Kluytmans JA, Box AT, et al. Rapid screening of methicillin-resistant Staphylococcus aureus using PCR and chromogenie agar: a prospective study to evaluate costs and effects. Clin Micro Infect 2010;16:17541761.
171.Denys GA, Renzi PB, Koch KM, Wissel CM. Three-way comparison of BBL CHROMagar MRSAII, MRSA select, and MR Spectra SA for detection of methicillin-resistant Staphylococcus aureus isolates in nasal surveillance cultures. J Clin Microbiol 2013;51:202205.
172.Safdar N, Narans L, Gordon B, Maki DG. Comparison of culture screening methods for detection of nasal carriage of methicillin-resistant Staphylococcus aureus: a prospective study comparing 32 methods. J Clin Microbiol 2003;41:31633166.
173.Wolk DM, Marx JL, Dominguez L, Driscoll D, Schifman RB. Comparison of MRSASelect agar, CHROMagar methicillin-resistant Staphylococcus aureus (MRSA) medium, and Xpert MRSA PCR for detection of MRSA in nares: diagnostic accuracy for surveillance samples with various bacterial densities. J Clin Microbiol 2009;47:39333936.
174.Nonhoff C, Denis O, Brenner A, et al. Comparison of three chromogenie media and enrichment broth media for the detection of methicillin-resistant Staphylococcus aureus from mucocutaneous screening specimens: comparison of MRSA chromogenie media. Eur J Clin Microbiol Infect Dis 2009;28:363369.
175.Huletsky A, Lebel P, Picard FJ, et al. Identification of methicillin-resistant Staphylococcus aureus carriage in less than 1 hour during a hospital surveillance program. Clin Infect Dis 2005; 40:976981.
176.Warren DK, Liao RS, Merz LR, Eveland M, Dunne WM Jr.Detection of methicillin-resistant Staphylococcus aureus directly from nasal swab specimens by a real-time PCR assay. J Clin Miaobiol 2004;42:55785581.
177.Drews SJ, Willey BM, Kreiswirth N, et al. Verification of the IDI-MRSA assay for detecting methicillin-resistant Staphylococcus aureus in diverse specimen types in a core clinical laboratory setting, J Clin Microbiol 2006;44:37943796.
178.Wong H, Louie L, Lo RY, Simor AE. Characterization of Staphylococcus aureus isolates with a partial or complete absence of staphylococcal cassette chromosome elements. J Clin Microbiol 2010;48:35253531.
179.Blanc DS, Basset P, Nahimana-Tessemo I, Jaton K, Greub G, Zanetti G.High proportion of wrongly identified methicillin-resistant Staphylococcus aureus carriers by use of a rapid commercial PCR assay due to presence of staphylococcal cassette chromosome element lacking the mecA gene, J Clin Microbiol 2011;49:722724.
180.Bartels MD, Boye K, Rohde SM, et al. A common variant of staphylococcal cassette chromosome mec type IVa in isolates from Copenhagen, Denmark, is not detected by the BD GeneOhm methicillin-resistant Staphylococcus aureus assay. J Clin Miaobiol 2009;47:15241527.
181.Laurent C, Bogaerts P, Schoevaerdts D, et al. Evaluation of the Xpert MRSA assay for rapid detection of methicillin-resistant Staphylococcus aureus from nares swabs of geriatric hospitalized patients and failure to detect a specific SCC mec type IV variant. Eur J Clin Microbiol Infect Dis 2010;29:9951002.
182.Cunningham R, Jenks P, Northwood J, Wallis M, Ferguson S, Hunt S.Effect on MRSA transmission of rapid PCR testing of patients admitted to critical care. J Hosp Infect 2007;65: 2428.
183.Bootsma MC, Diekmann O, Bonten MJ. Controlling methi-cillin-resistant Staphylococcus aureus: quantifying the effects of interventions and rapid diagnostic testing. Proc Nati Acad Sci USA 2006;103:56205625.
184.Olchanski N, Mathews C, Fusfeld L, Jarvis W.Assessment of the influence of test characteristics on the clinical and cost impacts of methicillin-resistant Staphylococcus aureus screening programs in US hospitals. Infect Control Hosp Epidemiol 2011; 32:250257.
185.Li J, Ulvin K, Biboh H, Kristiansen IS. Cost-effectiveness of supplementing a broth-enriched culture test with the Xpert meticillin-resistant Staphylococcus aureus (MRSA) assay for screening inpatients at high risk of MRSA. J Hosp Infect 2012; 82:227233.
186.Jeyaratnam D, Whitty CJ, Phillips K, et al. Impact of rapid screening tests on acquisition of meticillin resistant Staphylococcus aureus: cluster randomised crossover trial. BMJ 2008; 336:927930.
187.Safdar N, Marx J, Meyer NA, Maki DG. Effectiveness of preemptive barrier precautions in controlling nosocomial colonization and infection by methicillin-resistant Staphylococcus aureus in a burn unit. Am J Infect Control 2006;34:476483.
188.Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008;336(7650):924926.
189.GRADE. Canadian Task Force on Preventive Health Care website. http://canadiantaskforce.ca/methods/grade/. Accessed December 31, 2013.
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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
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