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Successful Eradication of a Monoclonal Strain of Klebsiella pneumoniae during a K. pneumoniae Carbapenemase-Producing K. pneumoniae Outbreak in a Surgical Intensive Care Unit in Miami, Florida

  • L. Silvia Munoz-Price (a1) (a2), Carolina De La Cuesta (a1) (a2), Stephen Adams (a2), Mary Wyckoff (a3) (a2), Timothy Cleary (a4), Sandra P. McCurdy (a5), Michael D. Huband (a5), M. Megan Lemmon (a5), MaryKay Lescoe (a5), Fadia B. Dibhajj (a5), Mary K. Hayden (a6) (a7), Karen Lolans (a6) and John P. Quinn (a5)...


We describe the investigation and control of a Klebsiella pneumoniae carbapenemase-producing K. pneumoniae outbreak in a 20-bed surgical intensive care unit during the period from January 1, 2009 through January 1, 2010. Nine patients were either colonized or infected with a monoclonal strain of K. pneumoniae. The implementation of a bundle of interventions on July 2009 successfully controlled the further horizontal spread of this organism.


Corresponding author

Jackson Memorial Hospital, Park Plaza West L-302, 1611 NW 12th Avenue, Miami, FL 33136-1096, (


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1.Nordmann, P, Cuzon, G, Naas, T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009;9:228236.
2.Patel, G, Huprikar, S, Factor, SH, Jenkins, SG, Calfee, DP. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008;29:10991106.
3.Gasink, LB, Edelstein, PH, Lautenbach, E, Synnestvedt, M, Fishman, NO. Risk factors and clinical impact of Klebsiella pneumoniae carbapenemaseproducing K. pneumoniae. Infect Control Hosp Epidemid 2009;30:11801185.
4.Clinical Laboratory Standards Institute (CLSI). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standard. CLSI document M07-A8. 8th ed. Wayne, PA: CLSI; 2009.
5.Clinical Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing: 19th informational supplement. CLSI document M100-S19. Wayne, PA: CLSI; 2009.
6.Tenover, FC, Arbeit, RD, Goering, RV, et al.Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:22332239.
7.Lolans, K, Calvert, K, Won, S, Clark, J, Hayden, MK. Direct ertapenem disk screening method for identification of KPC-producing Klebsiella pneumoniae and Escherichia coli in surveillance swab specimens. J Clin Microbiol 2010;48:836841.
8.Kochar, S, Sheard, T, Sharma, R, et al. Success of an infection control program to reduce the spread of carbapenem-resistant Klebsiella pneumoniae. Infect Control Hosp Epidemiol 2009;30:447452.
9.Munoz-Price, LS, Hayden, MK, Lolans, K, et al.Successful control of an outbreak of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae at a long-term acute care hospital. Infect Control Hosp Epidemiol 2010;31:341347.
10. Centers for Disease Control and Prevention (CDC). Guidance for control of infections with carbapenem-resistant or carbapenemase-producing En-terobacteriaceae in acute care facilities. MMWR Morb Mortal Wkly Rep 2009;58:256260.
11.Leavitt, A, Navon-Venezia, S, Chmelnitsky, I, Schwaber, MJ, Carmeli, Y. Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. Antimicrob Agents Chemother 2007;51:30263029.
12.Bratu, S, Landman, D, Haag, R, et al.Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch Intern Med 2005;165:14301435.
13.Munoz-Price, LS, Quinn, JP. The spread of Klebsiella pneumoniae car-bapenemases: a tale of strains, plasmids, and transposons. Clin Infect Dis 2009;49:17391741.
14.Srinivasan, A, Patel, JB. Klebsiella pneumoniae carbapenemase-producing organisms: an ounce of prevention really is worth a pound of cure. Infect Control Hosp Epidemiol 2008;29:11071109.
15. Research Committee of the Society of Healthcare Epidemiology of America. SHEA position paper. Enhancing patient safety by reducing healthcare-associated infections: the role of discovery and dissemination. Infect Control Hosp Epidemiol 2010;31:118123.


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