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Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL)

Published online by Cambridge University Press:  20 November 2013

Kathryn A. Ellis*
Affiliation:
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne; St. Vincent's Aged Psychiatry Service, St George's Hospital, Kew, Victoria, Australia Florey Institute of Neuroscience and Mental Health (MHRI), Parkville, Victoria, Australia National Ageing Research Institute (NARI), Parkville, Victoria, Australia
Cassandra Szoeke
Affiliation:
National Ageing Research Institute (NARI), Parkville, Victoria, Australia Commonwealth Scientific and Industrial Research Organisation, Preventative Health Flagship, CMSE CMIS (CSIRO), Parkville, Victoria, Australia
Ashley I. Bush
Affiliation:
Florey Institute of Neuroscience and Mental Health (MHRI), Parkville, Victoria, Australia
David Darby
Affiliation:
Florey Institute of Neuroscience and Mental Health (MHRI), Parkville, Victoria, Australia
Petra L. Graham
Affiliation:
Macquarie University, Sydney, NSW, Australia
Nicola T. Lautenschlager
Affiliation:
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne; St. Vincent's Aged Psychiatry Service, St George's Hospital, Kew, Victoria, Australia School of Psychiatry and Clinical Neurosciences and WA Centre for Health and Ageing, University of Western Australia, Crawley, WA, Australia
S. Lance Macaulay
Affiliation:
Commonwealth Scientific and Industrial Research Organisation, Preventative Health Flagship, CMSE CMIS (CSIRO), Parkville, Victoria, Australia
Ralph N. Martins
Affiliation:
Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia
Paul Maruff
Affiliation:
CogState Limited, Melbourne, Victoria, Australia
Colin L. Masters
Affiliation:
Florey Institute of Neuroscience and Mental Health (MHRI), Parkville, Victoria, Australia
Simon J. McBride
Affiliation:
Commonwealth Scientific and Industrial Research Organisation, Preventative Health Flagship, CMSE CMIS (CSIRO), Parkville, Victoria, Australia
Kerryn E. Pike
Affiliation:
Latrobe University, Melbourne, Victoria, Australia
Stephanie R. Rainey-Smith
Affiliation:
Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, WA, Australia
Alan Rembach
Affiliation:
Florey Institute of Neuroscience and Mental Health (MHRI), Parkville, Victoria, Australia
Joanne Robertson
Affiliation:
Florey Institute of Neuroscience and Mental Health (MHRI), Parkville, Victoria, Australia
Christopher C. Rowe
Affiliation:
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia Department of Medicine, University of Melbourne; Austin Health, Heidelberg, Victoria, Australia
Greg Savage
Affiliation:
Macquarie University, Sydney, NSW, Australia
Victor L. Villemagne
Affiliation:
Florey Institute of Neuroscience and Mental Health (MHRI), Parkville, Victoria, Australia Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
Michael Woodward
Affiliation:
Austin Health, Aged Care, Heidelberg, Victoria, Australia
William Wilson
Affiliation:
Commonwealth Scientific and Industrial Research Organisation, Preventative Health Flagship, CMSE CMIS (CSIRO), Parkville, Victoria, Australia
Ping Zhang
Affiliation:
Commonwealth Scientific and Industrial Research Organisation, Preventative Health Flagship, CMSE CMIS (CSIRO), Parkville, Victoria, Australia
David Ames
Affiliation:
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne; St. Vincent's Aged Psychiatry Service, St George's Hospital, Kew, Victoria, Australia National Ageing Research Institute (NARI), Parkville, Victoria, Australia
*
Correspondence should be addressed to: Kathryn A. Ellis, Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, 155 Oak Street Parkville, VIC 3052, Australia. Phone: +61-39389-2919; Fax: +61-39387-5061. Email: kellis@unimelb.edu.au.

Abstract

Background:

The Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing is a prospective study of 1,112 individuals (211 with Alzheimer's disease (AD), 133 with mild cognitive impairment (MCI), and 768 healthy controls (HCs)). Here we report diagnostic and cognitive findings at the first (18-month) follow-up of the cohort. The first aim was to compute rates of transition from HC to MCI, and MCI to AD. The second aim was to characterize the cognitive profiles of individuals who transitioned to a more severe disease stage compared with those who did not.

Methods:

Eighteen months after baseline, participants underwent comprehensive cognitive testing and diagnostic review, provided an 80 ml blood sample, and completed health and lifestyle questionnaires. A subgroup also underwent amyloid PET and MRI neuroimaging.

Results:

The diagnostic status of 89.9% of the cohorts was determined (972 were reassessed, 28 had died, and 112 did not return for reassessment). The 18-month cohort comprised 692 HCs, 82 MCI cases, 197 AD patients, and one Parkinson's disease dementia case. The transition rate from HC to MCI was 2.5%, and cognitive decline in HCs who transitioned to MCI was greatest in memory and naming domains compared to HCs who remained stable. The transition rate from MCI to AD was 30.5%.

Conclusion:

There was a high retention rate after 18 months. Rates of transition from healthy aging to MCI, and MCI to AD, were consistent with established estimates. Follow-up of this cohort over longer periods will elucidate robust predictors of future cognitive decline.

Type
Research Article
Copyright
Copyright © International Psychogeriatric Association 2013 

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