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Toxicity of lofepramine in heart disease
Published online by Cambridge University Press: 13 June 2014
Abstract
Lofepramine at the upper limit of its therapeutic range (210mg/day), was associated with the development of sinus tachycardia with atrial ectopic beats and progression of right bundle branch block to trifascicular block in an 82 year old man with a history of heart disease. As with any antidepressant administered in a high therapeutic dose, caution and regular electrocardiographic monitoring of elderly patients with heart disease receiving lofepramine is recommended.
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- Clinical and Brief Reports
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- Copyright © Cambridge University Press 1990
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