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Antimutagenic activity of whole casein on the pepper-induced mutagenicity to streptomycin-dependent strain SD 510 of Salmonella typhimurium TA 98

Published online by Cambridge University Press:  01 June 2009

Akiyoshi Hosono ,
Kunigal N. Shashikanth  and
Hajime Otani
Akiyoshi Hosono
Affiliation:
Department of Animal Husbandry, Shinshu University, Ina, Nagano-Ken, 399-45Japan
Kunigal N. Shashikanth
Affiliation:
Central Food Technological Research Institute, Mysore, 570013India
Hajime Otani
Affiliation:
Department of Animal Husbandry, Shinshu University, Ina, Nagano-Ken, 399-45Japan
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Summary

When the antimutagenic activity of milk or cultured milk components on the pepper-induced mutagenicity to streptomycin-dependent strain SD 510 of Salmonella typhimurium TA 98 was investigated, whole casein showed a significant antimutagenic activity. Heating at 121 °C for 15 min completely destroyed the antimutagenic activity of casein, which was temperature dependent. While acid or papain digestion resulted in the loss of antimutagenic activity of casein, trypsin digestion had little effect although the digestion of casein by each proteinase was over 75%. β-Casein, egg albumin, and bovine serum albumin also had a similar antimutagenic activity to that of whole casein.

Type
Original articles
Information
Journal of Dairy Research , Volume 55 , Issue 3 , August 1988 , pp. 435 - 442
Copyright
Copyright © Proprietors of Journal of Dairy Research 1988

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References

REFERENCES

Aschaffenburg, R. 1963 Preparation of β-casein by a modified urea fractionation method. Journal of Dairy Research 30 259–260CrossRefGoogle Scholar
Buchanan, R. L., Goldstein, S. & Budroe, J. D. 1981 Examination of chilli pepper and nutmeg oleoresins using the Salmonelle/mammalian microsome mutagenicity assay. Journal of Food Science 47 330–331, 333CrossRefGoogle Scholar
Friend, B. A. & Shahani, K. M. 1984 a Nutritional and therapeutic aspects of lactobacilli. Journal of Applied Nutrition 36 125–153Google Scholar
Friend, B. A. & Shahani, K. M. 1984 b Antitumor properties of lactobacilli and dairy products fermented by lactobacilli. Journal of Food Protection 47 717–723CrossRefGoogle Scholar
Fujiwara, M. 1966 The nutritional value of Allium plants in the relations with thiamine. (Seminar on thiamine sponsored by U.S. –Japan Cooperative Science Programme, pp. 1–18)Google Scholar
Hosono, A., Kashina, T. & Kada, T. 1986 a Antimutagenic properties of lactic acid-cultured milk on chemical and fecal mutagens. Journal of Dairy Science 69 2237–2242CrossRefGoogle ScholarPubMed
Hosono, A., Omote, E., Izawa, Y., Tokita, F. & Kada, T. 1986 b Isolation of spontaneous induced-streptomycin dependent mutants of Salmonella typhimurium TA98 and TA100 strains and desmutagenicity tests in vitro of cultured milk. Lebensmittel-Wissenschaft und Technologie 19 161–163Google Scholar
Hosono, A., Sagae, S. & Tokita, F. 1986 c Desmutagenic effect of cultured milk on chemically induced mutagenesis in Escherichia coli B/r WP2 trp hcr. Milchwissenschaft 41 142–145Google Scholar
Hosono, A., Suzuki, H. & Otani, H. 1987 a Mutagenicities of selected spices and desmutagenic compounds in regard to spice-induced mutagenicity. Japanese Journal of Zootechnical Science 58 413–420Google Scholar
Hosono, A., Suzuki, H. & Otani, H. 1987 b Induction of mutagenicity in cured pork by heat treatment. Japanese Journal of Zootechnical Science 58 886–892Google Scholar
Hosono, A., Yastuki, K. & Tokita, F. 1977 Isolation and characterization of an inhibitory substance against Escherichia coli produced by Lactobacillus acidophilus. Milchwissenschaft 32 727–730Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. 1951 Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193 265–275Google ScholarPubMed
Marcus, C. & Lichtenstein, E. P. 1982 Interactions of naturally occurring food plant components with insecticides and phenobarbital in rats and mice. Journal of Agricultural and Food Chemistry 30 563–568CrossRefGoogle Scholar
Murthy, V. S., Shashikanth, K. N. & Basappa, S. C. 1983 Anti-microbial action and therapeutics of garlic. Journal of Science and Research 42 410–414Google Scholar
Namiki, K., Yamanaka, M., Osawa, T. & Namiki, M. 1984 Mutagen formation by nitrite-spice reactions. Journal of Agricultural and Food Chemistry 32 948–952CrossRefGoogle Scholar
Shashikanth, K. N., Basappa, S. C. & Murthy, V. S. 1986 Effect of feeding raw and boiled garlic (A. sativum L.) extracts on the growth, caecal microflora and serum proteins of albino rats. Nutrition Reports International 33 313–319Google Scholar
Shashikanth, K. N. & Hosono, A. 1986 In vitro mutagenicity of tropical spices to streptomycin-dependent strains of Salmonella typhimurium TA 98. Agricultural and Biological Chemistry 50 2947–2948Google Scholar
Zittle, C. A. & Custer, J. H. 1963 Purification and some of the properties of αs1-casein and κ-casein. Journal of Dairy Science 46 1183–1188CrossRefGoogle Scholar