Skip to main content
×
Home
    • Aa
    • Aa

A meta-analysis of sperm donation offspring health outcomes

  • D. H. Adams (a1), R. A. Clark (a1), M. J. Davies (a2) and S. de Lacey (a1)
Abstract

Although the use of donor sperm as a treatment modality for male infertility has become common place, the health outcomes for those conceived has been poorly studied. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the health outcomes of offspring conceived from donor sperm. Eight studies were eligible and included in the review, and of these, three were included in a meta-analysis. Meta-analysis of clinical outcomes showed that donor sperm neonates are not at increased risk of being born of low birth weight (<2500 g), preterm (<37 weeks) or with increased incidences of birth defects, than spontaneously conceived neonates.

Copyright
Corresponding author
*Address for correspondence: D. Adams, School of Nursing and Midwifery, Flinders University, Bedford Park, SA 5042, Australia. (Email: adam0072@flinders.edu.au)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. ATGregoire , RCMayer . The impregnators. Fertil Steril. 1965; 16, 130134.

2. SLBoulet , AMehta , DMKissin , et al. Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection. JAMA. 2015; 313, 255263.

3. TJain , RSGupta . Trends in the use of intracytoplasmic sperm injection in the United States. N Engl J Med. 2007; 357, 251257.

4. SIMoskovtsev , DDacanay , ABaratz , et al. Significant increase in utilization of donor sperm by lesbian couples after the ligalization of same sex marriages in Ontario, Canada. Fertil Steril. 2013; 100, S67, O-219.

5. TViloria , NGarrido , FMinaya , et al. Report of results obtained in 2934 women using donor sperm: donor insemination versus in vitro fertilization according to indication. Fertil Steril. 2011; 96, 11341137.

6. VJadva , SBadger , MMorrissette , SGolombok . ‘Mom by choice, single by life’s circumstance…’ Findings from a large scale survey of the experiences of single mothers by choice. Hum Fertil (Camb). 2009; 12, 175184.

7. MGonzález-Comadran , JUrresta Avila , ASaavedra Tascón , et al. The impact of donor insemination on the risk of preeclampsia: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2014; 182, 160166.

8. GNSmith , MWalker , JLTessier , KGMillar . Increased incidence of preeclampsia in women conceiving by intrauterine insemination with donor versus partner sperm for treatment of primary infertility. Am J Obstet Gynecol. 1997; 177, 455458.

9. JHoy , AVenn , JHalliday , GKovacs , KWaalwyk . Perinatal and obstetric outcomes of donor insemination using cryopreserved semen in Victoria, Australia. Hum Reprod. 1999; 14, 17601764.

10. OSalha , VSharma , TDada , et al. The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod. 1999; 14, 22682273.

11. JANeed , BBell , EMeffin , WRJones . Pre-eclampsia in pregnancies from donor inseminations. J Reprod Immunol. 1983; 5, 329338.

12. JRChallis , CJLockwood , LMyatt , et al. Inflammation and pregnancy. Reprod Sci. 2009; 16, 206215.

13. KZetterström , SNLindeberg , BHaglund , UHanson . Chronic hypertension as a risk factor for offspring to be born small for gestational age. Acta Obstet Gynecol Scand. 2006; 85, 10461050.

14. JJGeelhoed , AFraser , KTilling , et al. Preeclampsia and gestational hypertension are associated with childhood blood pressure independently of family adiposity measures: the Avon Longitudinal Study of Parents and Children. Circulation. 2010; 122, 11921199.

15. PYJayet , SFRimoldi , TStuber , et al. Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia. Circulation. 2010; 122, 488494.

17. EFDavis , LNewton , AJLewandowski , et al. Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies. Clin Sci (Lond). 2012; 123, 5372.

18. EFDavis , MLazdam , AJLewandowski , et al. Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review. Pediatrics. 2012; 129, e1552e1561.

19. CSWu , YSun , MVestergaard , et al. Preeclampsia and risk for epilepsy in offspring. Pediatrics. 2008; 122, 10721078.

20. CSWu , EANohr , BHBech , et al. Health of children born to mothers who had preeclampsia: a population-based cohort study. Am J Obstet Gynecol. 2009; 201, 269.e1269.e10.

21. EKajantie , JGEriksson , COsmond , KThornburg , DJBarker . Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki Birth Cohort Study. Stroke. 2009; 40, 11761180.

22. JRMann , SMcDermott , HBao , JHardin , A.Gregg Pre-eclampsia, birth weight, and autism spectrum disorders. J Autism Dev Disord. 2010; 40, 548554.

23. SSaito , AShiozaki , ANakashima , MSakai , YSasaki . The role of the immune system in preeclampsia. Mol Aspects Med. 2007; 28, 192209.

24. ILSargent , AMBorzychowski , CWRedman . Immunoregulation in normal pregnancy and pre-eclampsia: an overview. Reprod Biomed Online. 2006; 13, 680686.

25. DKyrou , EMKolibianakis , PDevroey , HMFatemi . Is the use of donor sperm associated with a higher incidence of preeclampsia in women who achieve pregnancy after intrauterine insemination? Fertil Steril. 2010; 93, 11241127.

27. DGebhardt . Sperm donor suffers years later from inherited disease. J Med Ethics. 2002; 28, 213214.

28. PCallum , LMessiaen , PBower , et al. Gonosomal mosaicism for an NF1 deletion in a sperm donor: evidence of the need for co-ordinated, long-term communication of health information among relevant parties. Hum Reprod. 2012; 27, 12231226.

30. NZribi , NFeki Chakroun , HEl Euch , et al. Effects of cryopreservation on human sperm deoxyribonucleic acid integrity. Fertil Steril. 2010; 93, 159166.

31. LHDalzell , CMMcVicar , NMcClure , DLutton , SELewis . Effects of short and long incubations on DNA fragmentation of testicular sperm. Fertil Steril. 2004; 82, 14431445.

32. MDi Santo , NTarozzi , MNadalini , ABorini . Human sperm cryopreservation: update on techniques, effect on DNA integrity, and implications for ART. Adv Urol. 2012; 2012, 854837.

33. EToro , SFernández , AColomar , et al. Processing of semen can result in increased sperm DNA fragmentation. Fertil Steril. 2009; 92, 21092112.

34. LKThomson , SDFleming , RJAitken , et al. Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis. Hum Reprod. 2009; 24, 20612070.

35. CTatone , GDi Emidio , MVento , RCiriminna , PGArtini . Cryopreservation and oxidative stress in reproductive cells. Gynecol Endocrinol. 2010; 26, 563567.

37. QAClass , MERickert , PLichtenstein , BMD’Onofrio . Birth weight, physical morbidity, and mortality: a population-based sibling-comparison study. Am J Epidemiol. 2014; 179, 550558.

38. KCalkins , SUDevaskar . Fetal origins of adult disease. Curr Probl Pediatr Adolesc Health Care. 2011; 41, 158176.

41. KJBarrington , AJanvier . The paediatric consequences of assisted reproductive technologies, with special emphasis on multiple pregnancies. Acta Paediatr. 2013; 102, 340348.

43. AThapar , GHarold , FRice , et al. Do intrauterine or genetic influences explain the foetal origins of chronic disease? A novel experimental method for disentangling effects. BMC Med Res Methodol. 2007; 7, 25.

44. MGaudoin , RDobbie , AFinlayson , et al. Ovulation induction/intrauterine insemination in infertile couples is associated with low-birth-weight infants. Am J Obstet Gynecol. 2003; 188, 611616.

47. MJDavies , VMMoore , KJWillson , et al. Reproductive technologies and the risk of birth defects. N Engl J Med. 2012; 366, 18031813.

48. JLansac , FThepot , MJMayaux , et al. Pregnancy outcome after artificial insemination or IVF with frozen semen donor: a collaborative study of the French CECOS Federation on 21597 pregnancies. Eur J Obstet Gynecol Reprod Biol. 1997; 74, 223228.

49. RAForse , CFAckman , FCFraser . Possible teratogenic effects of artificial insemination by donor. Clin Genet. 1985; 28, 2326.

51. Society for Assisted Reproductive Technology, American Society for Reproductive Medicine. Assisted reproductive technology in the United States and Canada: 1995 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril. 1998; 69, 389398.

52. Society for Assisted Reproductive Technology, American Society for Reproductive Medicine. Assisted reproductive technology in the United States and Canada: 1994 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril. 1996; 66, 697705.

54. American Fertility Society & Society of Assisted Reproductive Technology. Assisted reproductive technology in the United States and Canada: 1992 results generated from the American Fertility Society/Society for Assisted Reproductive Technology Registry. Fertil Steril. 1994; 62, 11211128.

56. BBlondel , MDKogan , GRAlexander , et al. The impact of the increasing number of multiple births on the rates of preterm birth and low birthweight: an international study. Am J Public Health. 2002; 92, 13231330.

57. PPoikkeus , TSaisto , RLPunamaki , et al. Birth experience of women conceiving with assisted reproduction: a prospective multicenter study. Acta Obstet Gynecol Scand. 2014; 93, 880887.

58. EGillet , EMartens , GMartens , HCammu . Prelabour caesarean section following IVF/ICSI in older-term nulliparous women: too precious to push? J Pregnancy. 2011; 2011, 362518.

63. AMBrant , YMunakata , DIBoomsma , et al. The nature and nurture of high IQ: an extended sensitive period for intellectual development. Psychol Sci. 2013; 24, 14871495.

65. SPaul , SHarbottle , JAStewart . Recruitment of sperm donors: the Newcastle-upon-Tyne experience 1994-2003. Hum Reprod. 2006; 21, 150158.

67. MJTomlinson , KPooley , APierce , JFHopkisson . Sperm donor recruitment within an NHS fertility service since the removal of anonymity. Hum Fertil (Camb). 2010; 13, 159167.

68. UShukla , BDeval , MJansa Perez , et al. Sperm donor recruitment, attitudes and provider practices – 5 years after the removal of donor anonymity. Hum Reprod. 2013; 28, 676682.

69. APacey . Sperm donor recruitment in the UK. TOG. 2010; 12, 4348.

70. American Academy of Pediatrics, Section on Ophthalmology, Council on Children with Disabilities; American Academy of Ophthalmology; American Association for Pediatric Ophthalmology and Strabismus; American Association of Certified Orthoptists. Joint statement – learning disabilities, dyslexia, and vision. Pediatrics. 2009; 124, 837844.

71. TEScruggs , MAMastropieri . On babies and bathwater: addressing the problems of identification of learning disabilities. Learn Disabil Q. 2002; 25, 155168.

72. GRLyon . Learning disabilities. Future Child. 1996; 6, 5476.

74. SIPfeiffer . Identifying gifted and talented students. J Appl School Psychol. 2002; 19, 3150.

75. JHalliday , CWilson , KHammarberg , et al. Comparing indicators of health and development of singleton young adults conceived with and without assisted reproductive technology. Fertil Steril. 2014; 101, 10551063.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Developmental Origins of Health and Disease
  • ISSN: 2040-1744
  • EISSN: 2040-1752
  • URL: /core/journals/journal-of-developmental-origins-of-health-and-disease
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
WORD
Supplementary Materials

Adams supplementary material S1
Supplementary Table

 Word (12 KB)
12 KB
WORD
Supplementary Materials

Adams supplementary material S2
Supplementary Table

 Word (31 KB)
31 KB

Metrics

Altmetric attention score