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Infant gut immunity: a preliminary study of IgA associations with breastfeeding

Published online by Cambridge University Press:  21 December 2015

S. L. Bridgman
Affiliation:
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
T. Konya
Affiliation:
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
M. B. Azad
Affiliation:
Department of Pediatrics and Child Health, Children’s Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada
M. R. Sears
Affiliation:
Department of Medicine, de Groote School of Medicine, McMaster University, Hamilton, ON, Canada
A. B. Becker
Affiliation:
Department of Pediatrics and Child Health, Children’s Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada
S. E. Turvey
Affiliation:
Department of Pediatrics, Child & Family Research Institute and BC Children’s Hospital, University of British Columbia, Vancouver, BC, Canada
P. J. Mandhane
Affiliation:
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
P. Subbarao
Affiliation:
Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
J. A. Scott
Affiliation:
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
C. J. Field
Affiliation:
Department of Agriculture, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada
A. L. Kozyrskyj
Affiliation:
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
CHILD Study Investigators
Affiliation:
Canadian Healthy Infant Longitudinal Development Study
Corresponding

Abstract

Secretory immunoglobulin A (IgA) plays a critical role in gut mucosal immune defense. Initially provided by breastmilk, IgA production by the infant gut is gradually stimulated by developing gut microbiota. This study reports associations between infant fecal IgA concentrations 4 months after birth, breastfeeding status and other pre/postnatal exposures in 47 infants in the Canadian Healthy Infant Longitudinal Development cohort. Breastfed infants and first-born infants had higher median fecal IgA concentrations (23.11 v. 9.34 µg/g protein, P<0.01 and 22.19 v. 8.23 µg/g protein, P=0.04). IgA levels increased successively with exclusivity of breastfeeding (β-coefficient, 0.37, P<0.05). This statistical association was independent of maternal parity and household pets. In the absence of breastfeeding, female sex and pet exposure elevated fecal IgA to levels found in breastfed infants. In addition to breastfeeding, infant fecal IgA associations with pre/postnatal exposures may affect gut immunity and risk of allergic disease.

Type
Brief Report
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016 

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Supplementary material: File

Bridgman Supplementary Material

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