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Infant gut immunity: a preliminary study of IgA associations with breastfeeding

  • S. L. Bridgman (a1), T. Konya (a2), M. B. Azad (a3), M. R. Sears (a4), A. B. Becker (a3), S. E. Turvey (a5), P. J. Mandhane (a1), P. Subbarao (a6), J. A. Scott (a2), C. J. Field (a7) and A. L. Kozyrskyj (a1)...

Secretory immunoglobulin A (IgA) plays a critical role in gut mucosal immune defense. Initially provided by breastmilk, IgA production by the infant gut is gradually stimulated by developing gut microbiota. This study reports associations between infant fecal IgA concentrations 4 months after birth, breastfeeding status and other pre/postnatal exposures in 47 infants in the Canadian Healthy Infant Longitudinal Development cohort. Breastfed infants and first-born infants had higher median fecal IgA concentrations (23.11 v. 9.34 µg/g protein, P<0.01 and 22.19 v. 8.23 µg/g protein, P=0.04). IgA levels increased successively with exclusivity of breastfeeding (β-coefficient, 0.37, P<0.05). This statistical association was independent of maternal parity and household pets. In the absence of breastfeeding, female sex and pet exposure elevated fecal IgA to levels found in breastfed infants. In addition to breastfeeding, infant fecal IgA associations with pre/postnatal exposures may affect gut immunity and risk of allergic disease.

Corresponding author
*Address for correspondence: S. Bridgman, Department of Pediatrics, University of Alberta, 3-529 Edmonton Clinic Health Academy, 11405–87th Avenue, Edmonton, AB, Canada T6G IC9. (Email
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1. P Brandtzaeg . Secretory IgA: designed for anti-microbial defense. Front Immunol. 2013; 4, 222.

2. AK Koutras , VJ Vigorita . Fecal secretory immunoglobulin A in breast milk versus formula feeding in early infancy. J Pediatr Gastroenterol Nutr. 1989; 9, 5861.

3. K Maruyama , M Hida , T Kohgo , Y Fukunaga . Changes in salivary and fecal secretory IgA in infants under different feeding regimens. Pediatr Int. 2009; 51, 342345.

4. AJ Battersby , DL Gibbons . The gut mucosal immune system in the neonatal period. Pediatr Allergy Immunol. 2013; 24, 414421.

5. A Kawano , Y Emori . Changes in maternal secretory immunoglobulin A levels in human milk during 12 weeks after parturition. Am J Hum Biol. 2013; 25, 399403.

6. MK McGuire , MA McGuire . Human milk: mother nature’s prototypical probiotic food? Adv Nutr. 2015; 6, 112123.

7. CS Kaetzel . Cooperativity among secretory IgA, the polymeric immunoglobulin receptor, and the gut microbiota promotes host-microbial mutualism. Immunol Lett. 2014; 162(Pt A), 1021.

8. A Mathias , B Pais , L Favre , J Benyacoub , B Corthesy . Role of secretory IgA in the mucosal sensing of commensal bacteria. Gut Microbes. 2014; 5, 688695.

11. L Orivuori , G Loss , C Roduit , et al. Soluble immunoglobulin A in breast milk is inversely associated with atopic dermatitis at early age: the PASTURE cohort study. Clin Exp Allergy. 2014; 44, 102112.

12. A Sandin , B Bjorksten , MF Bottcher , et al. High salivary secretory IgA antibody levels are associated with less late-onset wheezing in IgE-sensitized infants. Pediatr Allergy Immunol. 2011; 22, 477481.

13. P Subbarao , SS Anand , AB Becker , et al. The Canadian Healthy Infant Longitudinal Development (CHILD) study: examining developmental origins of allergy and asthma. Thorax. 2015; 70, 9981000.

14. O Ballard , AL Morrow . Human milk composition: nutrients and bioactive factors. Pediatr Clin North Am. 2013; 60, 4974.

16. H Kohler , S Donarski , B Stocks , et al. Antibacterial characteristics in the feces of breast-fed and formula-fed infants during the first year of life. J Pediatr Gastroenterol Nutr. 2002; 34, 188193.

17. P Bachour , R Yafawi , F Jaber , E Choueiri , Z Abdel-Razzak . Effects of smoking, mother’s age, body mass index, and parity number on lipid, protein, and secretory immunoglobulin A concentrations of human milk. Breastfeed Med. 2012; 7, 179188.

18. E Bezirtzoglou , A Tsiotsias , GW Welling . Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH). Anaerobe. 2011; 17, 478482.

20. J Penders , C Vink , C Driessen , et al. Quantification of Bifidobacterium spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR. FEMS Microbiol Lett. 2005; 243, 141147.

21. B Levast , M Berri , HL Wilson , F Meurens , H Salmon . Development of gut immunoglobulin A production in piglet in response to innate and environmental factors. Dev Comp Immunol. 2014; 44, 235244.

22. J Penders , K Gerhold , EE Stobberingh , et al. Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood. J Allergy Clin Immunol. 2013; 132, 601607.

23. CA Sandman , LM Glynn , EP Davis . Is there a viability-vulnerability tradeoff? Sex differences in fetal programming. J Psychosom Res. 2013; 75, 327335.

25. MB Azad , T Konya , H Maughan , et al. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy Asthma Clin Immunol. 2013; 9, 15.

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Journal of Developmental Origins of Health and Disease
  • ISSN: 2040-1744
  • EISSN: 2040-1752
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